SNP Detail Info-rs10735366

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 12	NC_000012.12:g.99372428G>A
GRCh37.p13 chr 12	NC_000012.11:g.99766206G>A
ANKS1B RefSeqGene	NG_029860.1:g.617227C>T

Gene: ANKS1B, ankyrin repeat and sterile alpha motif domain containing 1B(minus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
ANKS1B transcript variant 1	NM_152788.4:c.	N/A	Intron Variant
ANKS1B transcript variant 4	NM_001204065.1:c.	N/A	Genic Upstream Transcript Variant
ANKS1B transcript variant 5	NM_001204066.1:c.	N/A	Genic Upstream Transcript Variant
ANKS1B transcript variant 6	NM_001204067.1:c.	N/A	Genic Upstream Transcript Variant
ANKS1B transcript variant 7	NM_001204068.1:c.	N/A	Genic Upstream Transcript Variant
ANKS1B transcript variant 8	NM_001204069.1:c.	N/A	Genic Upstream Transcript Variant
ANKS1B transcript variant 9	NM_001204070.1:c.	N/A	Genic Upstream Transcript Variant
ANKS1B transcript variant 10	NM_001204079.1:c.	N/A	Genic Upstream Transcript Variant
ANKS1B transcript variant 11	NM_001204080.1:c.	N/A	Genic Upstream Transcript Variant
ANKS1B transcript variant 12	NM_001204081.1:c.	N/A	Genic Upstream Transcript Variant
ANKS1B transcript variant 3	NM_020140.3:c.	N/A	Genic Upstream Transcript Variant
ANKS1B transcript variant 2	NM_181670.3:c.	N/A	Genic Upstream Transcript Variant
ANKS1B transcript variant X9	XM_005269028.4:c.	N/A	Intron Variant
ANKS1B transcript variant X13	XM_005269029.4:c.	N/A	Intron Variant
ANKS1B transcript variant X2	XM_006719504.3:c.	N/A	Intron Variant
ANKS1B transcript variant X3	XM_006719505.3:c.	N/A	Intron Variant
ANKS1B transcript variant X4	XM_006719506.3:c.	N/A	Intron Variant
ANKS1B transcript variant X6	XM_006719507.3:c.	N/A	Intron Variant
ANKS1B transcript variant X10	XM_006719508.3:c.	N/A	Intron Variant
ANKS1B transcript variant X11	XM_006719509.3:c.	N/A	Intron Variant
ANKS1B transcript variant X16	XM_006719510.3:c.	N/A	Intron Variant
ANKS1B transcript variant X18	XM_006719512.3:c.	N/A	Intron Variant
ANKS1B transcript variant X19	XM_006719513.3:c.	N/A	Intron Variant
ANKS1B transcript variant X21	XM_006719514.3:c.	N/A	Intron Variant
ANKS1B transcript variant X14	XM_011538571.2:c.	N/A	Intron Variant
ANKS1B transcript variant X1	XM_017019651.1:c.	N/A	Intron Variant
ANKS1B transcript variant X5	XM_017019652.1:c.	N/A	Intron Variant
ANKS1B transcript variant X7	XM_017019653.1:c.	N/A	Intron Variant
ANKS1B transcript variant X8	XM_017019654.1:c.	N/A	Intron Variant
ANKS1B transcript variant X12	XM_017019655.1:c.	N/A	Intron Variant
ANKS1B transcript variant X15	XM_017019656.1:c.	N/A	Intron Variant
ANKS1B transcript variant X17	XM_017019657.1:c.	N/A	Intron Variant
ANKS1B transcript variant X20	XM_017019658.1:c.	N/A	Intron Variant
ANKS1B transcript variant X30	XM_005269032.3:c.	N/A	Genic Upstream Transcript Variant
ANKS1B transcript variant X23	XM_017019659.1:c.	N/A	Genic Upstream Transcript Variant
ANKS1B transcript variant X24	XM_017019660.1:c.	N/A	Genic Upstream Transcript Variant
ANKS1B transcript variant X25	XM_017019661.1:c.	N/A	Genic Upstream Transcript Variant
ANKS1B transcript variant X26	XM_017019662.1:c.	N/A	Genic Upstream Transcript Variant
ANKS1B transcript variant X27	XM_017019663.1:c.	N/A	Genic Upstream Transcript Variant
ANKS1B transcript variant X28	XM_017019664.1:c.	N/A	Genic Upstream Transcript Variant
ANKS1B transcript variant X29	XM_017019665.1:c.	N/A	Genic Upstream Transcript Variant
ANKS1B transcript variant X22	XR_001748815.1:n.	N/A	Intron Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.001	A=0.999
1000Genomes	American	Sub	694	G=0.020	A=0.980
1000Genomes	East Asian	Sub	1008	G=0.001	A=0.999
1000Genomes	Europe	Sub	1006	G=0.037	A=0.963
1000Genomes	Global	Study-wide	5008	G=0.017	A=0.983
1000Genomes	South Asian	Sub	978	G=0.030	A=0.970
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.042	A=0.958
The Genome Aggregation Database	African	Sub	8734	G=0.008	A=0.992
The Genome Aggregation Database	American	Sub	836	G=0.020	A=0.980
The Genome Aggregation Database	East Asian	Sub	1620	G=0.001	A=0.999
The Genome Aggregation Database	Europe	Sub	18476	G=0.049	A=0.950
The Genome Aggregation Database	Global	Study-wide	29968	G=0.033	A=0.966
The Genome Aggregation Database	Other	Sub	302	G=0.040	A=0.960
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.023	A=0.976
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.041	A=0.959

PMID	Title	Author	Journal
19268276	Genome-wide association study of smoking initiation and current smoking.	Vink JM	Am J Hum Genet

P-Value

SNP ID	p-value	Traits	Study
rs10735366	0.000846	nicotine smoking	19268276

eQTL of rs10735366 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs10735366 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr12	99725501	99725607	E070	-40599
chr12	99726701	99726828	E070	-39378
chr12	99726846	99726947	E070	-39259
chr12	99727251	99727390	E070	-38816
chr12	99728350	99728400	E070	-37806
chr12	99728506	99728868	E070	-37338
chr12	99782147	99782655	E070	15941
chr12	99782684	99782786	E070	16478
chr12	99782793	99782941	E070	16587
chr12	99726168	99726260	E073	-39946
chr12	99726701	99726828	E073	-39378
chr12	99779626	99779676	E082	13420
chr12	99779713	99779840	E082	13507

rs10735366

Genomic Coordinates

Gene: ANKS1B, ankyrin repeat and sterile alpha motif domain containing 1B(minus strand)

Population Frequency

P-Value

eQTL of rs10735366 in Brain tissues (GTEx Analysis Release V7)

meQTL of rs10735366 in Fetal Brain

Genomic View

Chromatin Interaction

Enhancer Annotation (GRCh37.p13)