rs10743428

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0359 (10740/29902,GnomAD)
C=0313 (9129/29116,TOPMED)
C=0287 (1435/5008,1000G)
C=0480 (1848/3854,ALSPAC)
C=0480 (1779/3708,TWINSUK)
chr12:21952634 (GRCh38.p7) (12p12.1)
AD
GWASdb2
1   publication(s)
See rs on genome
9 Enhancers around
18 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 12NC_000012.12:g.21952634T>C
GRCh37.p13 chr 12NC_000012.11:g.22105568T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.906C=0.094
1000GenomesAmericanSub694T=0.680C=0.320
1000GenomesEast AsianSub1008T=0.715C=0.285
1000GenomesEuropeSub1006T=0.488C=0.512
1000GenomesGlobalStudy-wide5008T=0.713C=0.287
1000GenomesSouth AsianSub978T=0.710C=0.290
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.520C=0.480
The Genome Aggregation DatabaseAfricanSub8716T=0.847C=0.153
The Genome Aggregation DatabaseAmericanSub834T=0.690C=0.310
The Genome Aggregation DatabaseEast AsianSub1616T=0.723C=0.277
The Genome Aggregation DatabaseEuropeSub18434T=0.536C=0.463
The Genome Aggregation DatabaseGlobalStudy-wide29902T=0.640C=0.359
The Genome Aggregation DatabaseOtherSub302T=0.490C=0.510
Trans-Omics for Precision MedicineGlobalStudy-wide29116T=0.686C=0.313
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.520C=0.480
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs107434280.000472alcohol dependence21314694

eQTL of rs10743428 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10743428 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr122206127622061342E070-44226
chr122206142522061503E070-44065
chr122206152522061624E070-43944
chr122206197322062013E070-43555
chr122206457222064693E070-40875
chr122206473022064780E070-40788
chr122206484422064923E070-40645
chr122206492922065085E070-40483
chr122206851922068713E070-36855

Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr122209348422095486E067-10082
chr122209244922092673E068-12895
chr122209281922093189E068-12379
chr122209320422093350E068-12218
chr122209348422095486E068-10082
chr122209348422095486E069-10082
chr122209244922092673E071-12895
chr122209281922093189E071-12379
chr122209320422093350E071-12218
chr122209348422095486E071-10082
chr122209244922092673E072-12895
chr122209281922093189E072-12379
chr122209320422093350E072-12218
chr122209348422095486E072-10082
chr122209320422093350E073-12218
chr122209348422095486E073-10082
chr122209348422095486E074-10082
chr122209348422095486E082-10082