rs10745574

Homo sapiens
A>G
LOC105369901 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0392 (11701/29822,GnomAD)
A==0381 (11121/29118,TOPMED)
A==0423 (2117/5008,1000G)
A==0351 (1351/3854,ALSPAC)
A==0356 (1321/3708,TWINSUK)
chr12:91937812 (GRCh38.p7) (12q21.33)
AD
GWASdb2
1   publication(s)
See rs on genome
39 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 12NC_000012.12:g.91937812A>G
GRCh37.p13 chr 12NC_000012.11:g.92331588A>G

Gene: LOC105369901, uncharacterized LOC105369901(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105369901 transcript variant X2XR_001749253.1:n.N/AIntron Variant
LOC105369901 transcript variant X3XR_001749254.1:n.N/AIntron Variant
LOC105369901 transcript variant X4XR_001749255.1:n.N/AIntron Variant
LOC105369901 transcript variant X5XR_001749256.1:n.N/AIntron Variant
LOC105369901 transcript variant X1XR_945202.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.441G=0.559
1000GenomesAmericanSub694A=0.480G=0.520
1000GenomesEast AsianSub1008A=0.402G=0.598
1000GenomesEuropeSub1006A=0.379G=0.621
1000GenomesGlobalStudy-wide5008A=0.423G=0.577
1000GenomesSouth AsianSub978A=0.430G=0.570
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.351G=0.649
The Genome Aggregation DatabaseAfricanSub8696A=0.427G=0.573
The Genome Aggregation DatabaseAmericanSub834A=0.500G=0.500
The Genome Aggregation DatabaseEast AsianSub1582A=0.387G=0.613
The Genome Aggregation DatabaseEuropeSub18408A=0.372G=0.627
The Genome Aggregation DatabaseGlobalStudy-wide29822A=0.392G=0.607
The Genome Aggregation DatabaseOtherSub302A=0.290G=0.710
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.381G=0.618
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.356G=0.644
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs107455740.00049alcohol dependence20201924

eQTL of rs10745574 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10745574 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr129237908692379878E06747498
chr129237992792380182E06748339
chr129238034192380598E06748753
chr129237840992378679E06846821
chr129237992792380182E06848339
chr129238034192380598E06848753
chr129228522792285267E070-46321
chr129228561292285704E070-45884
chr129228576992286134E070-45454
chr129228620492286429E070-45159
chr129228649492286710E070-44878
chr129229048492291024E070-40564
chr129229110292291152E070-40436
chr129237726192377311E07045673
chr129237735892377408E07045770
chr129237741092377494E07045822
chr129237779292377997E07046204
chr129237822292378408E07046634
chr129237840992378679E07046821
chr129237889292379063E07047304
chr129237908692379878E07047498
chr129237992792380182E07048339
chr129238034192380598E07048753
chr129238073892380790E07049150
chr129238096992381013E07049381
chr129237889292379063E07147304
chr129237908692379878E07147498
chr129237992792380182E07148339
chr129238034192380598E07148753
chr129238073892380790E07149150
chr129238096992381013E07149381
chr129237908692379878E07447498
chr129237992792380182E07448339
chr129228576992286134E081-45454
chr129228620492286429E081-45159
chr129228649492286710E081-44878
chr129229110292291152E081-40436
chr129228576992286134E082-45454
chr129228620492286429E082-45159