rs10746034

Homo sapiens
C>T
LOC105369955 : Intron Variant
LOC105369956 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0203 (6095/29952,GnomAD)
C==0212 (6181/29118,TOPMED)
C==0174 (871/5008,1000G)
C==0234 (900/3854,ALSPAC)
C==0241 (892/3708,TWINSUK)
chr12:105433635 (GRCh38.p7) (12q23.3)
AD
GWASdb2
1   publication(s)
See rs on genome
28 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 12NC_000012.12:g.105433635C>T
GRCh37.p13 chr 12NC_000012.11:g.105827413C>T

Gene: LOC105369955, uncharacterized LOC105369955(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105369955 transcriptXR_945295.2:n.N/AIntron Variant

Gene: LOC105369956, uncharacterized LOC105369956(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105369956 transcriptXR_945297.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.144T=0.856
1000GenomesAmericanSub694C=0.180T=0.820
1000GenomesEast AsianSub1008C=0.086T=0.914
1000GenomesEuropeSub1006C=0.247T=0.753
1000GenomesGlobalStudy-wide5008C=0.174T=0.826
1000GenomesSouth AsianSub978C=0.230T=0.770
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.234T=0.766
The Genome Aggregation DatabaseAfricanSub8720C=0.186T=0.814
The Genome Aggregation DatabaseAmericanSub836C=0.190T=0.810
The Genome Aggregation DatabaseEast AsianSub1620C=0.100T=0.900
The Genome Aggregation DatabaseEuropeSub18474C=0.221T=0.778
The Genome Aggregation DatabaseGlobalStudy-wide29952C=0.203T=0.796
The Genome Aggregation DatabaseOtherSub302C=0.190T=0.810
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.212T=0.787
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.241T=0.759
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs107460340.00022Alcohol dependence (early age of onset)20201924
rs107460340.00064alcohol dependence20201924

eQTL of rs10746034 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10746034 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr12105802827105803041E068-24372
chr12105803167105804542E068-22871
chr12105802276105802326E069-25087
chr12105802563105802685E069-24728
chr12105802827105803041E070-24372
chr12105803167105804542E070-22871
chr12105871685105871951E07044272
chr12105802276105802326E071-25087
chr12105803167105804542E071-22871
chr12105861209105861277E07133796
chr12105802276105802326E074-25087
chr12105802563105802685E074-24728
chr12105802827105803041E074-24372
chr12105803167105804542E074-22871
chr12105802827105803041E081-24372
chr12105803167105804542E081-22871
chr12105804635105804693E081-22720
chr12105857977105858500E08130564
chr12105864183105864233E08136770
chr12105864371105864443E08136958
chr12105873830105873896E08146417
chr12105873929105874324E08146516
chr12105802827105803041E082-24372
chr12105803167105804542E082-22871
chr12105804635105804693E082-22720
chr12105804990105805044E082-22369
chr12105858536105858600E08231123
chr12105858674105858728E08231261