rs10755432

Homo sapiens
A>C
PHF3 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0463 (13789/29764,GnomAD)
A==0387 (11275/29118,TOPMED)
A==0408 (2045/5008,1000G)
C=0464 (1788/3854,ALSPAC)
C=0476 (1765/3708,TWINSUK)
chr6:63687952 (GRCh38.p7) (6q12)
AD
GWASdb2
1   publication(s)
See rs on genome
168 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.63687952A>C
GRCh37.p13 chr 6NC_000006.11:g.64397853A>C
PHF3 RefSeqGeneNG_034034.1:g.57151A>C

Gene: PHF3, PHD finger protein 3(plus strand)

Molecule type Change Amino acid[Codon] SO Term
PHF3 transcript variant 2NM_001290259.1:c.N/AIntron Variant
PHF3 transcript variant 1NM_015153.3:c.N/AIntron Variant
PHF3 transcript variant 3NM_001290260.1:c.N/AGenic Downstream Transcript Variant
PHF3 transcript variant X2XM_005248701.3:c.N/AIntron Variant
PHF3 transcript variant X4XM_005248702.3:c.N/AIntron Variant
PHF3 transcript variant X6XM_005248703.3:c.N/AIntron Variant
PHF3 transcript variant X3XM_006715426.3:c.N/AIntron Variant
PHF3 transcript variant X1XM_011535648.2:c.N/AIntron Variant
PHF3 transcript variant X5XM_017010626.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.195C=0.805
1000GenomesAmericanSub694A=0.370C=0.630
1000GenomesEast AsianSub1008A=0.542C=0.458
1000GenomesEuropeSub1006A=0.558C=0.442
1000GenomesGlobalStudy-wide5008A=0.408C=0.592
1000GenomesSouth AsianSub978A=0.430C=0.570
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.536C=0.464
The Genome Aggregation DatabaseAfricanSub8656A=0.225C=0.775
The Genome Aggregation DatabaseAmericanSub832A=0.400C=0.600
The Genome Aggregation DatabaseEast AsianSub1616A=0.545C=0.455
The Genome Aggregation DatabaseEuropeSub18358A=0.570C=0.429
The Genome Aggregation DatabaseGlobalStudy-wide29764A=0.463C=0.536
The Genome Aggregation DatabaseOtherSub302A=0.490C=0.510
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.387C=0.612
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.524C=0.476
PMID Title Author Journal
22096494A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study.Zuo LPLoS One

P-Value

SNP ID p-value Traits Study
rs107554320.00034alcohol dependence22096494

eQTL of rs10755432 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr6:64397853LGSNENSG00000146166.12A>C1.9599e-12367971Brain_Spinal_cord_cervical

meQTL of rs10755432 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr66435003264350267E067-47586
chr66435031064350429E067-47424
chr66435152264351562E067-46291
chr66435166464351729E067-46124
chr66435326564353367E067-44486
chr66435340364353453E067-44400
chr66435355064353597E067-44256
chr66435379964354122E067-43731
chr66435416464354298E067-43555
chr66435476664354995E067-42858
chr66435648464356589E067-41264
chr66435939164359514E067-38339
chr66435987964359966E067-37887
chr66436979364369833E067-28020
chr66436995664370043E067-27810
chr66437046564370839E067-27014
chr66437340864373737E067-24116
chr66438461664384840E067-13013
chr66438674564387006E067-10847
chr66438706764387235E067-10618
chr66438727564387534E067-10319
chr66440013864400208E0672285
chr66440027264400351E0672419
chr66441189064411952E06714037
chr66434815264348219E068-49634
chr66434830464348374E068-49479
chr66434916664349250E068-48603
chr66435003264350267E068-47586
chr66435031064350429E068-47424
chr66435340364353453E068-44400
chr66435355064353597E068-44256
chr66435379964354122E068-43731
chr66435416464354298E068-43555
chr66435476664354995E068-42858
chr66435500564355161E068-42692
chr66435939164359514E068-38339
chr66435987964359966E068-37887
chr66436003464360162E068-37691
chr66436979364369833E068-28020
chr66436995664370043E068-27810
chr66437046564370839E068-27014
chr66437319564373307E068-24546
chr66437407864374118E068-23735
chr66438549764385541E068-12312
chr66438646464386529E068-11324
chr66438674564387006E068-10847
chr66438706764387235E068-10618
chr66438727564387534E068-10319
chr66434815264348219E069-49634
chr66434830464348374E069-49479
chr66435003264350267E069-47586
chr66435031064350429E069-47424
chr66435326564353367E069-44486
chr66435340364353453E069-44400
chr66435355064353597E069-44256
chr66435379964354122E069-43731
chr66435416464354298E069-43555
chr66435476664354995E069-42858
chr66435500564355161E069-42692
chr66435939164359514E069-38339
chr66435987964359966E069-37887
chr66436598564366056E069-31797
chr66436979364369833E069-28020
chr66436995664370043E069-27810
chr66437046564370839E069-27014
chr66437383464373908E069-23945
chr66438461664384840E069-13013
chr66438508664385323E069-12530
chr66438534064385412E069-12441
chr66438549764385541E069-12312
chr66438646464386529E069-11324
chr66438674564387006E069-10847
chr66438706764387235E069-10618
chr66438727564387534E069-10319
chr66434815264348219E070-49634
chr66434815264348219E071-49634
chr66434830464348374E071-49479
chr66434916664349250E071-48603
chr66435003264350267E071-47586
chr66435031064350429E071-47424
chr66435326564353367E071-44486
chr66435340364353453E071-44400
chr66435355064353597E071-44256
chr66435379964354122E071-43731
chr66435416464354298E071-43555
chr66435476664354995E071-42858
chr66435500564355161E071-42692
chr66435939164359514E071-38339
chr66435987964359966E071-37887
chr66436003464360162E071-37691
chr66436979364369833E071-28020
chr66436995664370043E071-27810
chr66437046564370839E071-27014
chr66437319564373307E071-24546
chr66437340864373737E071-24116
chr66437383464373908E071-23945
chr66437407864374118E071-23735
chr66438461664384840E071-13013
chr66438508664385323E071-12530
chr66438534064385412E071-12441
chr66438549764385541E071-12312
chr66438646464386529E071-11324
chr66438674564387006E071-10847
chr66438706764387235E071-10618
chr66438727564387534E071-10319
chr66435003264350267E072-47586
chr66435031064350429E072-47424
chr66435152264351562E072-46291
chr66435166464351729E072-46124
chr66435326564353367E072-44486
chr66435340364353453E072-44400
chr66435355064353597E072-44256
chr66435379964354122E072-43731
chr66435416464354298E072-43555
chr66435476664354995E072-42858
chr66435500564355161E072-42692
chr66435939164359514E072-38339
chr66435987964359966E072-37887
chr66436794864368043E072-29810
chr66436812864368168E072-29685
chr66437046564370839E072-27014
chr66438646464386529E072-11324
chr66438674564387006E072-10847
chr66438706764387235E072-10618
chr66438727564387534E072-10319
chr66439308664393166E072-4687
chr66435003264350267E073-47586
chr66435031064350429E073-47424
chr66435416464354298E073-43555
chr66435476664354995E073-42858
chr66435939164359514E073-38339
chr66434916664349250E074-48603
chr66435003264350267E074-47586
chr66435031064350429E074-47424
chr66435152264351562E074-46291
chr66435166464351729E074-46124
chr66435326564353367E074-44486
chr66435340364353453E074-44400
chr66435355064353597E074-44256
chr66435379964354122E074-43731
chr66435416464354298E074-43555
chr66435476664354995E074-42858
chr66435500564355161E074-42692
chr66435939164359514E074-38339
chr66435987964359966E074-37887
chr66436003464360162E074-37691
chr66436979364369833E074-28020
chr66436995664370043E074-27810
chr66437046564370839E074-27014
chr66438375864383814E074-14039
chr66438461664384840E074-13013
chr66438508664385323E074-12530
chr66438534064385412E074-12441
chr66438549764385541E074-12312
chr66438646464386529E074-11324
chr66438674564387006E074-10847
chr66438706764387235E074-10618
chr66438727564387534E074-10319
chr66434916664349250E081-48603
chr66435003264350267E081-47586
chr66435031064350429E081-47424
chr66438706764387235E081-10618
chr66438727564387534E081-10319
chr66434815264348219E082-49634
chr66434830464348374E082-49479
chr66434916664349250E082-48603
chr66435379964354122E082-43731
chr66435416464354298E082-43555