rs10774464

Homo sapiens
C>T
WNK1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0497 (14899/29922,GnomAD)
T=0462 (13477/29118,TOPMED)
C==0464 (2322/5008,1000G)
C==0465 (1791/3854,ALSPAC)
C==0462 (1713/3708,TWINSUK)
chr12:813242 (GRCh38.p7) (12p13.33)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 12NC_000012.12:g.813242C>T
GRCh37.p13 chr 12NC_000012.11:g.922408C>T
WNK1 RefSeqGeneNG_007984.3:g.65184C>T

Gene: WNK1, WNK lysine deficient protein kinase 1(plus strand)

Molecule type Change Amino acid[Codon] SO Term
WNK1 transcript variant 4NM_001184985.1:c.N/AIntron Variant
WNK1 transcript variant 2NM_014823.2:c.N/AIntron Variant
WNK1 transcript variant 1NM_018979.3:c.N/AIntron Variant
WNK1 transcript variant 3NM_213655.4:c.N/AIntron Variant
WNK1 transcript variant X10XM_006719003.2:c.N/AIntron Variant
WNK1 transcript variant X1XM_011520997.2:c.N/AIntron Variant
WNK1 transcript variant X2XM_011520998.2:c.N/AIntron Variant
WNK1 transcript variant X3XM_011520999.2:c.N/AIntron Variant
WNK1 transcript variant X4XM_011521000.2:c.N/AIntron Variant
WNK1 transcript variant X5XM_011521001.2:c.N/AIntron Variant
WNK1 transcript variant X6XM_011521002.2:c.N/AIntron Variant
WNK1 transcript variant X7XM_011521003.2:c.N/AIntron Variant
WNK1 transcript variant X8XM_011521004.2:c.N/AIntron Variant
WNK1 transcript variant X11XM_011521006.2:c.N/AIntron Variant
WNK1 transcript variant X12XM_011521007.2:c.N/AIntron Variant
WNK1 transcript variant X18XM_011521008.2:c.N/AIntron Variant
WNK1 transcript variant X19XM_011521009.2:c.N/AIntron Variant
WNK1 transcript variant X13XM_017019834.1:c.N/AIntron Variant
WNK1 transcript variant X14XM_017019835.1:c.N/AIntron Variant
WNK1 transcript variant X15XM_017019836.1:c.N/AIntron Variant
WNK1 transcript variant X16XM_017019837.1:c.N/AIntron Variant
WNK1 transcript variant X17XM_017019838.1:c.N/AIntron Variant
WNK1 transcript variant X20XM_017019839.1:c.N/AIntron Variant
WNK1 transcript variant X9XM_011521005.2:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.665T=0.335
1000GenomesAmericanSub694C=0.390T=0.610
1000GenomesEast AsianSub1008C=0.196T=0.804
1000GenomesEuropeSub1006C=0.492T=0.508
1000GenomesGlobalStudy-wide5008C=0.464T=0.536
1000GenomesSouth AsianSub978C=0.490T=0.510
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.465T=0.535
The Genome Aggregation DatabaseAfricanSub8702C=0.616T=0.384
The Genome Aggregation DatabaseAmericanSub834C=0.360T=0.640
The Genome Aggregation DatabaseEast AsianSub1618C=0.191T=0.809
The Genome Aggregation DatabaseEuropeSub18468C=0.480T=0.519
The Genome Aggregation DatabaseGlobalStudy-wide29922C=0.502T=0.497
The Genome Aggregation DatabaseOtherSub300C=0.590T=0.410
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.537T=0.462
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.462T=0.538
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs107744640.00055alcohol dependence20201924

eQTL of rs10774464 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr12:922408RAD52ENSG00000002016.12C>T2.7481e-7-176811Cortex

meQTL of rs10774464 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr12875386875426E067-46982
chr12882617882657E067-39751
chr12882840882930E067-39478
chr12883207883731E067-38677
chr12883945884035E067-38373
chr12884976885123E067-37285
chr12885151885316E067-37092
chr12885907885962E067-36446
chr12886033886214E067-36194
chr12887957888043E067-34365
chr12888088888336E067-34072
chr12888408888482E067-33926
chr12888943889165E067-33243
chr12889191889296E067-33112
chr12889534889920E067-32488
chr12889965890237E067-32171
chr12890280890390E067-32018
chr12890436890537E067-31871
chr12890568890618E067-31790
chr12898043898294E067-24114
chr12898377898428E067-23980
chr12898612898673E067-23735
chr12898719898820E067-23588
chr12898911899380E067-23028
chr12899479899634E067-22774
chr12899681899840E067-22568
chr12899855899964E067-22444
chr12900035900122E067-22286
chr12902239902454E067-19954
chr12911469911651E067-10757
chr12911914912080E067-10328
chr12913841913938E067-8470
chr12913973914034E067-8374
chr12914246914514E067-7894
chr12914527914590E067-7818
chr12919303919353E067-3055
chr12919875920100E067-2308
chr12920242920303E067-2105
chr12920601920657E067-1751
chr12920822920975E067-1433
chr12921098921190E067-1218
chr12921402921617E067-791
chr12921642921765E067-643
chr12927856927932E0675448
chr12927971928207E0675563
chr12938392938442E06715984
chr12938466938520E06716058
chr12938692938757E06716284
chr12960505960830E06738097
chr12961653961729E06739245
chr12964528964568E06742120
chr12964673964764E06742265
chr12877043877142E068-45266
chr12877699877742E068-44666
chr12883207883731E068-38677
chr12883945884035E068-38373
chr12884711884903E068-37505
chr12884976885123E068-37285
chr12885151885316E068-37092
chr12885907885962E068-36446
chr12886033886214E068-36194
chr12886901887129E068-35279
chr12887173887266E068-35142
chr12887957888043E068-34365
chr12888943889165E068-33243
chr12889191889296E068-33112
chr12889306889490E068-32918
chr12889534889920E068-32488
chr12889965890237E068-32171
chr12890280890390E068-32018
chr12894998895172E068-27236
chr12896053896115E068-26293
chr12898377898428E068-23980
chr12898612898673E068-23735
chr12898719898820E068-23588
chr12898911899380E068-23028
chr12899479899634E068-22774
chr12899681899840E068-22568
chr12899855899964E068-22444
chr12900978901048E068-21360
chr12901072901219E068-21189
chr12901265901460E068-20948
chr12902088902138E068-20270
chr12902239902454E068-19954
chr12902697902755E068-19653
chr12905177905227E068-17181
chr12905517905650E068-16758
chr12905909905969E068-16439
chr12905994906034E068-16374
chr12913317913492E068-8916
chr12913602913651E068-8757
chr12913841913938E068-8470
chr12913973914034E068-8374
chr12914246914514E068-7894
chr12914527914590E068-7818
chr12915347916237E068-6171
chr12919770919826E068-2582
chr12919875920100E068-2308
chr12920242920303E068-2105
chr12920601920657E068-1751
chr12920822920975E068-1433
chr12921098921190E068-1218
chr12921402921617E068-791
chr12921642921765E068-643
chr12927650927700E0685242
chr12927856927932E0685448
chr12927971928207E0685563
chr12938392938442E06815984
chr12938466938520E06816058
chr12938692938757E06816284
chr12938961939030E06816553
chr12939079939119E06816671
chr12939159939199E06816751
chr12943611943655E06821203
chr12960252960333E06837844
chr12960505960830E06838097
chr12961157961392E06838749
chr12964140964238E06841732
chr12964528964568E06842120
chr12966586967203E06844178
chr12876749876947E069-45461
chr12877043877142E069-45266
chr12877225877305E069-45103
chr12877310877422E069-44986
chr12883207883731E069-38677
chr12884552884644E069-37764
chr12884711884903E069-37505
chr12884976885123E069-37285
chr12885151885316E069-37092
chr12888943889165E069-33243
chr12889191889296E069-33112
chr12889306889490E069-32918
chr12889534889920E069-32488
chr12889965890237E069-32171
chr12890280890390E069-32018
chr12890436890537E069-31871
chr12890568890618E069-31790
chr12891270891320E069-31088
chr12891372891422E069-30986
chr12891437891560E069-30848
chr12894224894545E069-27863
chr12896053896115E069-26293
chr12896670896710E069-25698
chr12896772896816E069-25592
chr12896820896908E069-25500
chr12896946896993E069-25415
chr12898719898820E069-23588
chr12898911899380E069-23028
chr12899479899634E069-22774
chr12899681899840E069-22568
chr12899855899964E069-22444
chr12900035900122E069-22286
chr12904239904289E069-18119
chr12904317904361E069-18047
chr12904379904440E069-17968
chr12904560904795E069-17613
chr12904800904894E069-17514
chr12904994905044E069-17364
chr12905177905227E069-17181
chr12911047911194E069-11214
chr12911469911651E069-10757
chr12915347916237E069-6171
chr12916267916365E069-6043
chr12916565916834E069-5574
chr12919770919826E069-2582
chr12919875920100E069-2308
chr12920242920303E069-2105
chr12921402921617E069-791
chr12921642921765E069-643
chr12927650927700E0695242
chr12927856927932E0695448
chr12960505960830E06938097
chr12961157961392E06938749
chr12961443961535E06939035
chr12961653961729E06939245
chr12961930962409E06939522
chr12966378966428E06943970
chr12966586967203E06944178
chr12967339967438E06944931
chr12967520967614E06945112
chr12967620967734E06945212
chr12919770919826E070-2582
chr12919875920100E070-2308
chr12920242920303E070-2105
chr12921402921617E070-791
chr12921642921765E070-643
chr12878982879093E071-43315
chr12881364881514E071-40894
chr12882496882546E071-39862
chr12882617882657E071-39751
chr12882840882930E071-39478
chr12883207883731E071-38677
chr12884711884903E071-37505
chr12884976885123E071-37285
chr12885151885316E071-37092
chr12885907885962E071-36446
chr12886033886214E071-36194
chr12886901887129E071-35279
chr12887173887266E071-35142
chr12887957888043E071-34365
chr12888088888336E071-34072
chr12888408888482E071-33926
chr12888943889165E071-33243
chr12889191889296E071-33112
chr12889306889490E071-32918
chr12889534889920E071-32488
chr12889965890237E071-32171
chr12890280890390E071-32018
chr12890436890537E071-31871
chr12890568890618E071-31790
chr12891270891320E071-31088
chr12891372891422E071-30986
chr12891437891560E071-30848
chr12894224894545E071-27863
chr12896053896115E071-26293
chr12898043898294E071-24114
chr12898377898428E071-23980
chr12898612898673E071-23735
chr12898719898820E071-23588
chr12898911899380E071-23028
chr12899479899634E071-22774
chr12899681899840E071-22568
chr12899855899964E071-22444
chr12900035900122E071-22286
chr12900429900521E071-21887
chr12900554900606E071-21802
chr12900717900757E071-21651
chr12900832900872E071-21536
chr12900978901048E071-21360
chr12901072901219E071-21189
chr12901265901460E071-20948
chr12901672901754E071-20654
chr12902088902138E071-20270
chr12902239902454E071-19954
chr12902697902755E071-19653
chr12902988903038E071-19370
chr12904379904440E071-17968
chr12904560904795E071-17613
chr12904800904894E071-17514
chr12904994905044E071-17364
chr12905177905227E071-17181
chr12905517905650E071-16758
chr12909905910134E071-12274
chr12910321910434E071-11974
chr12911047911194E071-11214
chr12911469911651E071-10757
chr12911914912080E071-10328
chr12912159912257E071-10151
chr12912378912462E071-9946
chr12913317913492E071-8916
chr12913602913651E071-8757
chr12913841913938E071-8470
chr12913973914034E071-8374
chr12914246914514E071-7894
chr12914527914590E071-7818
chr12915347916237E071-6171
chr12916267916365E071-6043
chr12919770919826E071-2582
chr12919875920100E071-2308
chr12920242920303E071-2105
chr12921098921190E071-1218
chr12921402921617E071-791
chr12921642921765E071-643
chr12925560926070E0713152
chr12926137926321E0713729
chr12927125927647E0714717
chr12927650927700E0715242
chr12927856927932E0715448
chr12927971928207E0715563
chr12928318928368E0715910
chr12928490928530E0716082
chr12928602928642E0716194
chr12928658928709E0716250
chr12938392938442E07115984
chr12938466938520E07116058
chr12938692938757E07116284
chr12938961939030E07116553
chr12939079939119E07116671
chr12939159939199E07116751
chr12943611943655E07121203
chr12957676957973E07135268
chr12958016958115E07135608
chr12958165958263E07135757
chr12958271958367E07135863
chr12958436958506E07136028
chr12958553958603E07136145
chr12960252960333E07137844
chr12960505960830E07138097
chr12961157961392E07138749
chr12961443961535E07139035
chr12961653961729E07139245
chr12961930962409E07139522
chr12962595962707E07140187
chr12876268876318E072-46090
chr12876455876505E072-45903
chr12876687876731E072-45677
chr12876749876947E072-45461
chr12877043877142E072-45266
chr12877225877305E072-45103
chr12877310877422E072-44986
chr12883207883731E072-38677
chr12884552884644E072-37764
chr12884711884903E072-37505
chr12884976885123E072-37285
chr12885151885316E072-37092
chr12886901887129E072-35279
chr12887173887266E072-35142
chr12888943889165E072-33243
chr12889191889296E072-33112
chr12889306889490E072-32918
chr12889534889920E072-32488
chr12889965890237E072-32171
chr12890280890390E072-32018
chr12890436890537E072-31871
chr12890568890618E072-31790
chr12898911899380E072-23028
chr12900035900122E072-22286
chr12902988903038E072-19370
chr12903060903113E072-19295
chr12903407903567E072-18841
chr12904800904894E072-17514
chr12904994905044E072-17364
chr12905177905227E072-17181
chr12919875920100E072-2308
chr12920242920303E072-2105
chr12927856927932E0725448
chr12927971928207E0725563
chr12939079939119E07216671
chr12939159939199E07216751
chr12939246939329E07216838
chr12939344939415E07216936
chr12939687939727E07217279
chr12960505960830E07238097
chr12964528964568E07242120
chr12964673964764E07242265
chr12966586967203E07244178
chr12967339967438E07244931
chr12967520967614E07245112
chr12967620967734E07245212
chr12877043877142E073-45266
chr12877225877305E073-45103
chr12877310877422E073-44986
chr12883207883731E073-38677
chr12884711884903E073-37505
chr12884976885123E073-37285
chr12885151885316E073-37092
chr12889534889920E073-32488
chr12889965890237E073-32171
chr12890280890390E073-32018
chr12896670896710E073-25698
chr12896772896816E073-25592
chr12896820896908E073-25500
chr12896946896993E073-25415
chr12898043898294E073-24114
chr12898377898428E073-23980
chr12898612898673E073-23735
chr12898719898820E073-23588
chr12898911899380E073-23028
chr12902239902454E073-19954
chr12902697902755E073-19653
chr12919770919826E073-2582
chr12919875920100E073-2308
chr12927856927932E0735448
chr12960505960830E07338097
chr12875386875426E074-46982
chr12877043877142E074-45266
chr12877225877305E074-45103
chr12877310877422E074-44986
chr12883207883731E074-38677
chr12885151885316E074-37092
chr12885907885962E074-36446
chr12886033886214E074-36194
chr12886901887129E074-35279
chr12887173887266E074-35142
chr12887957888043E074-34365
chr12888088888336E074-34072
chr12888408888482E074-33926
chr12888943889165E074-33243
chr12889191889296E074-33112
chr12889306889490E074-32918
chr12889534889920E074-32488
chr12889965890237E074-32171
chr12890280890390E074-32018
chr12890436890537E074-31871
chr12890568890618E074-31790
chr12898043898294E074-24114
chr12898377898428E074-23980
chr12898612898673E074-23735
chr12898719898820E074-23588
chr12898911899380E074-23028
chr12899479899634E074-22774
chr12899681899840E074-22568
chr12899855899964E074-22444
chr12900035900122E074-22286
chr12902239902454E074-19954
chr12902697902755E074-19653
chr12902988903038E074-19370
chr12903060903113E074-19295
chr12903407903567E074-18841
chr12903993904043E074-18365
chr12904239904289E074-18119
chr12904317904361E074-18047
chr12904379904440E074-17968
chr12904560904795E074-17613
chr12904800904894E074-17514
chr12904994905044E074-17364
chr12905177905227E074-17181
chr12905517905650E074-16758
chr12911469911651E074-10757
chr12911914912080E074-10328
chr12912159912257E074-10151
chr12912378912462E074-9946
chr12914246914514E074-7894
chr12914527914590E074-7818
chr12915168915210E074-7198
chr12915347916237E074-6171
chr12916267916365E074-6043
chr12916565916834E074-5574
chr12919303919353E074-3055
chr12919770919826E074-2582
chr12919875920100E074-2308
chr12920242920303E074-2105
chr12920601920657E074-1751
chr12920822920975E074-1433
chr12921098921190E074-1218
chr12921402921617E074-791
chr12921642921765E074-643
chr12921808921848E074-560
chr12927125927647E0744717
chr12927650927700E0745242
chr12927856927932E0745448
chr12927971928207E0745563
chr12938392938442E07415984
chr12938466938520E07416058
chr12938692938757E07416284
chr12938961939030E07416553
chr12939079939119E07416671
chr12939159939199E07416751
chr12958016958115E07435608
chr12960252960333E07437844
chr12960505960830E07438097
chr12961157961392E07438749
chr12961443961535E07439035
chr12961653961729E07439245
chr12961930962409E07439522
chr12964140964238E07441732
chr12964528964568E07442120
chr12964673964764E07442265
chr12887173887266E082-35142
chr12909905910134E082-12274