rs10777357

Homo sapiens
A>G
LOC105369901 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0465 (13906/29846,GnomAD)
A==0487 (14199/29118,TOPMED)
A==0488 (2446/5008,1000G)
A==0381 (1470/3854,ALSPAC)
A==0384 (1423/3708,TWINSUK)
chr12:91942918 (GRCh38.p7) (12q21.33)
AD
GWASdb2
1   publication(s)
See rs on genome
45 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 12NC_000012.12:g.91942918A>G
GRCh37.p13 chr 12NC_000012.11:g.92336694A>G

Gene: LOC105369901, uncharacterized LOC105369901(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105369901 transcript variant X2XR_001749253.1:n.N/AIntron Variant
LOC105369901 transcript variant X3XR_001749254.1:n.N/AIntron Variant
LOC105369901 transcript variant X4XR_001749255.1:n.N/AIntron Variant
LOC105369901 transcript variant X5XR_001749256.1:n.N/AIntron Variant
LOC105369901 transcript variant X1XR_945202.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.644G=0.356
1000GenomesAmericanSub694A=0.500G=0.500
1000GenomesEast AsianSub1008A=0.403G=0.597
1000GenomesEuropeSub1006A=0.411G=0.589
1000GenomesGlobalStudy-wide5008A=0.488G=0.512
1000GenomesSouth AsianSub978A=0.440G=0.560
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.381G=0.619
The Genome Aggregation DatabaseAfricanSub8710A=0.619G=0.381
The Genome Aggregation DatabaseAmericanSub836A=0.520G=0.480
The Genome Aggregation DatabaseEast AsianSub1586A=0.386G=0.614
The Genome Aggregation DatabaseEuropeSub18412A=0.400G=0.599
The Genome Aggregation DatabaseGlobalStudy-wide29846A=0.465G=0.534
The Genome Aggregation DatabaseOtherSub302A=0.320G=0.680
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.487G=0.512
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.384G=0.616
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs107773570.00047alcohol dependence20201924

eQTL of rs10777357 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10777357 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr129237908692379878E06742392
chr129237992792380182E06743233
chr129238034192380598E06743647
chr129237840992378679E06841715
chr129237992792380182E06843233
chr129238034192380598E06843647
chr129238185892382373E06845164
chr129238239492382520E06845700
chr129238254592382624E06845851
chr129238185892382373E06945164
chr129229048492291024E070-45670
chr129229110292291152E070-45542
chr129237726192377311E07040567
chr129237735892377408E07040664
chr129237741092377494E07040716
chr129237779292377997E07041098
chr129237822292378408E07041528
chr129237840992378679E07041715
chr129237889292379063E07042198
chr129237908692379878E07042392
chr129237992792380182E07043233
chr129238034192380598E07043647
chr129238073892380790E07044044
chr129238096992381013E07044275
chr129238135792381684E07044663
chr129238185892382373E07045164
chr129238239492382520E07045700
chr129238632392386403E07049629
chr129238650392386662E07049809
chr129237889292379063E07142198
chr129237908692379878E07142392
chr129237992792380182E07143233
chr129238034192380598E07143647
chr129238073892380790E07144044
chr129238096992381013E07144275
chr129238135792381684E07144663
chr129238185892382373E07245164
chr129238239492382520E07245700
chr129238254592382624E07245851
chr129237908692379878E07442392
chr129237992792380182E07443233
chr129238185892382373E07445164
chr129238239492382520E07445700
chr129229110292291152E081-45542
chr129238135792381684E08244663