rs10777366

Homo sapiens
C>A
LOC105369901 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0443 (13273/29914,GnomAD)
C==0462 (13471/29118,TOPMED)
C==0463 (2321/5008,1000G)
C==0371 (1428/3854,ALSPAC)
C==0370 (1373/3708,TWINSUK)
chr12:91959975 (GRCh38.p7) (12q21.33)
AD
GWASdb2
1   publication(s)
See rs on genome
57 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 12NC_000012.12:g.91959975C>A
GRCh37.p13 chr 12NC_000012.11:g.92353751C>A

Gene: LOC105369901, uncharacterized LOC105369901(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105369901 transcript variant X2XR_001749253.1:n.N/AIntron Variant
LOC105369901 transcript variant X3XR_001749254.1:n.N/AIntron Variant
LOC105369901 transcript variant X4XR_001749255.1:n.N/AIntron Variant
LOC105369901 transcript variant X5XR_001749256.1:n.N/AIntron Variant
LOC105369901 transcript variant X1XR_945202.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.601A=0.399
1000GenomesAmericanSub694C=0.500A=0.500
1000GenomesEast AsianSub1008C=0.398A=0.602
1000GenomesEuropeSub1006C=0.392A=0.608
1000GenomesGlobalStudy-wide5008C=0.463A=0.537
1000GenomesSouth AsianSub978C=0.400A=0.600
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.371A=0.629
The Genome Aggregation DatabaseAfricanSub8686C=0.571A=0.429
The Genome Aggregation DatabaseAmericanSub838C=0.520A=0.480
The Genome Aggregation DatabaseEast AsianSub1612C=0.372A=0.628
The Genome Aggregation DatabaseEuropeSub18476C=0.389A=0.611
The Genome Aggregation DatabaseGlobalStudy-wide29914C=0.443A=0.556
The Genome Aggregation DatabaseOtherSub302C=0.310A=0.690
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.462A=0.537
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.370A=0.630
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs107773660.0009alcohol dependence20201924

eQTL of rs10777366 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10777366 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr129237908692379878E06725335
chr129237992792380182E06726176
chr129238034192380598E06726590
chr129237840992378679E06824658
chr129237992792380182E06826176
chr129238034192380598E06826590
chr129238185892382373E06828107
chr129238239492382520E06828643
chr129238254592382624E06828794
chr129238185892382373E06928107
chr129237726192377311E07023510
chr129237735892377408E07023607
chr129237741092377494E07023659
chr129237779292377997E07024041
chr129237822292378408E07024471
chr129237840992378679E07024658
chr129237889292379063E07025141
chr129237908692379878E07025335
chr129237992792380182E07026176
chr129238034192380598E07026590
chr129238073892380790E07026987
chr129238096992381013E07027218
chr129238135792381684E07027606
chr129238185892382373E07028107
chr129238239492382520E07028643
chr129238632392386403E07032572
chr129238650392386662E07032752
chr129238681492386867E07033063
chr129238723692387286E07033485
chr129238746892387522E07033717
chr129238759792387694E07033846
chr129238770392387822E07033952
chr129238793492388056E07034183
chr129238810792388176E07034356
chr129238932392389447E07035572
chr129239728392397343E07043532
chr129239749692397540E07043745
chr129239762792397712E07043876
chr129239772092397824E07043969
chr129237889292379063E07125141
chr129237908692379878E07125335
chr129237992792380182E07126176
chr129238034192380598E07126590
chr129238073892380790E07126987
chr129238096992381013E07127218
chr129238135792381684E07127606
chr129238185892382373E07228107
chr129238239492382520E07228643
chr129238254592382624E07228794
chr129237908692379878E07425335
chr129237992792380182E07426176
chr129238185892382373E07428107
chr129238239492382520E07428643
chr129238770392387822E08133952
chr129238793492388056E08134183
chr129238810792388176E08134356
chr129238135792381684E08227606