rs10793832

Organism: Homo sapiens

Alleles: T>A / T>C

Gene : Feature

FBXL17 : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

C=0236 (7080/29942,GnomAD)
C=0197 (5760/29118,TOPMED)
C=0171 (857/5008,1000G)
C=0279 (1077/3854,ALSPAC)
C=0278 (1032/3708,TWINSUK)

Position: chr5:107984529 (GRCh38.p7) (5q21.3)

Phenotype: ND

Dataset:

GWASdb2

Publications: 2 publication(s)

Genomic View: See rs on genome

Enhancer: 0 Enhancer around

Promoter: 0 Promoter around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 5	NC_000005.10:g.107984529T>A
GRCh38.p7 chr 5	NC_000005.10:g.107984529T>C
GRCh37.p13 chr 5	NC_000005.9:g.107320230T>A
GRCh37.p13 chr 5	NC_000005.9:g.107320230T>C

Gene: FBXL17, F-box and leucine-rich repeat protein 17(minus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
FBXL17 transcript	NM_001163315.2:c.	N/A	Intron Variant
FBXL17 transcript variant X1	XM_005272048.4:c.	N/A	Intron Variant
FBXL17 transcript variant X2	XM_011543574.2:c.	N/A	Intron Variant
FBXL17 transcript variant X3	XM_011543575.2:c.	N/A	Intron Variant
FBXL17 transcript variant X11	XM_005272050.4:c.	N/A	Genic Downstream Transcript Variant
FBXL17 transcript variant X4	XM_011543576.2:c.	N/A	Genic Downstream Transcript Variant
FBXL17 transcript variant X5	XM_011543577.2:c.	N/A	Genic Downstream Transcript Variant
FBXL17 transcript variant X6	XM_011543578.2:c.	N/A	Genic Downstream Transcript Variant
FBXL17 transcript variant X8	XM_011543579.2:c.	N/A	Genic Downstream Transcript Variant
FBXL17 transcript variant X9	XM_011543580.2:c.	N/A	Genic Downstream Transcript Variant
FBXL17 transcript variant X7	XM_017009729.1:c.	N/A	Genic Downstream Transcript Variant
FBXL17 transcript variant X10	XR_427717.3:n.	N/A	Genic Downstream Transcript Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	T=0.884	C=0.116
1000Genomes	American	Sub	694	T=0.800	C=0.200
1000Genomes	East Asian	Sub	1008	T=0.938	C=0.062
1000Genomes	Europe	Sub	1006	T=0.721	C=0.279
1000Genomes	Global	Study-wide	5008	T=0.829	C=0.171
1000Genomes	South Asian	Sub	978	T=0.780	C=0.220
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	T=0.721	C=0.279
The Genome Aggregation Database	African	Sub	8728	T=0.869	C=0.131
The Genome Aggregation Database	American	Sub	838	T=0.790	C=0.210
The Genome Aggregation Database	East Asian	Sub	1618	T=0.902	C=0.098
The Genome Aggregation Database	Europe	Sub	18458	T=0.701	C=0.298
The Genome Aggregation Database	Global	Study-wide	29942	T=0.763	C=0.236
The Genome Aggregation Database	Other	Sub	300	T=0.700	C=0.300
Trans-Omics for Precision Medicine	Global	Study-wide	29118	T=0.802	C=0.197
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	T=0.722	C=0.278

PMID	Title	Author	Journal
19247474	Genome-wide and candidate gene association study of cigarette smoking behaviors.	Caporaso N	PLoS One
17158188	Novel genes identified in a high-density genome wide association study for nicotine dependence.	Bierut LJ	Hum Mol Genet

P-Value

SNP ID	p-value	Traits	Study
rs10793832	8.13E-05	nicotine dependence	17158188

eQTL of rs10793832 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs10793832 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.