rs10794077

Homo sapiens
G>A
ADAM12 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0320 (9591/29906,GnomAD)
G==0385 (11223/29118,TOPMED)
G==0392 (1962/5008,1000G)
G==0197 (758/3854,ALSPAC)
G==0206 (764/3708,TWINSUK)
chr10:126282489 (GRCh38.p7) (10q26.2)
ND
GWASdb2
1   publication(s)
See rs on genome
135 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.126282489G>A
GRCh37.p13 chr 10NC_000010.10:g.127971058G>A
ADAM12 RefSeqGeneNG_029050.1:g.111070C>T

Gene: ADAM12, ADAM metallopeptidase domain 12(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ADAM12 transcript variant 3NM_001288973.1:c.N/AIntron Variant
ADAM12 transcript variant 4NM_001288974.1:c.N/AIntron Variant
ADAM12 transcript variant 5NM_001288975.1:c.N/AIntron Variant
ADAM12 transcript variant 1NM_003474.5:c.N/AIntron Variant
ADAM12 transcript variant 2NM_021641.4:c.N/AIntron Variant
ADAM12 transcript variant X1XM_017016705.1:c.N/AIntron Variant
ADAM12 transcript variant X2XM_017016706.1:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.658A=0.342
1000GenomesAmericanSub694G=0.420A=0.580
1000GenomesEast AsianSub1008G=0.346A=0.654
1000GenomesEuropeSub1006G=0.206A=0.794
1000GenomesGlobalStudy-wide5008G=0.392A=0.608
1000GenomesSouth AsianSub978G=0.250A=0.750
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.197A=0.803
The Genome Aggregation DatabaseAfricanSub8670G=0.596A=0.404
The Genome Aggregation DatabaseAmericanSub838G=0.400A=0.600
The Genome Aggregation DatabaseEast AsianSub1616G=0.337A=0.663
The Genome Aggregation DatabaseEuropeSub18480G=0.188A=0.811
The Genome Aggregation DatabaseGlobalStudy-wide29906G=0.320A=0.679
The Genome Aggregation DatabaseOtherSub302G=0.230A=0.770
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.385A=0.614
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.206A=0.794
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs107940770.000745nicotine dependence17158188

eQTL of rs10794077 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10794077 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr10127923475127923525E067-47533
chr10127923528127923712E067-47346
chr10127923833127924159E067-46899
chr10127924233127924524E067-46534
chr10127924709127924768E067-46290
chr10127924833127924885E067-46173
chr10127925005127925075E067-45983
chr10127928647127928732E067-42326
chr10127928920127929545E067-41513
chr10127929611127929811E067-41247
chr10127930574127932979E067-38079
chr10127923833127924159E068-46899
chr10127924233127924524E068-46534
chr10127924709127924768E068-46290
chr10127924833127924885E068-46173
chr10127925005127925075E068-45983
chr10127928647127928732E068-42326
chr10127928920127929545E068-41513
chr10127929611127929811E068-41247
chr10127929909127929990E068-41068
chr10127930219127930324E068-40734
chr10127930574127932979E068-38079
chr10127923279127923329E069-47729
chr10127923475127923525E069-47533
chr10127923528127923712E069-47346
chr10127923833127924159E069-46899
chr10127924233127924524E069-46534
chr10127924709127924768E069-46290
chr10127924833127924885E069-46173
chr10127928647127928732E069-42326
chr10127928920127929545E069-41513
chr10127929611127929811E069-41247
chr10127929909127929990E069-41068
chr10127930219127930324E069-40734
chr10127930418127930468E069-40590
chr10127930574127932979E069-38079
chr10127922497127922726E070-48332
chr10127922913127923055E070-48003
chr10127923279127923329E070-47729
chr10127923475127923525E070-47533
chr10127923528127923712E070-47346
chr10127923833127924159E070-46899
chr10127924233127924524E070-46534
chr10127924709127924768E070-46290
chr10127924833127924885E070-46173
chr10127925005127925075E070-45983
chr10127925237127925290E070-45768
chr10127925390127925444E070-45614
chr10127925599127925691E070-45367
chr10127928647127928732E070-42326
chr10127928920127929545E070-41513
chr10127929611127929811E070-41247
chr10127929909127929990E070-41068
chr10127930219127930324E070-40734
chr10127930418127930468E070-40590
chr10127930574127932979E070-38079
chr10127990868127991915E07019810
chr10127991994127992071E07020936
chr10127923279127923329E071-47729
chr10127923475127923525E071-47533
chr10127923528127923712E071-47346
chr10127923833127924159E071-46899
chr10127924233127924524E071-46534
chr10127924709127924768E071-46290
chr10127924833127924885E071-46173
chr10127925005127925075E071-45983
chr10127928647127928732E071-42326
chr10127928920127929545E071-41513
chr10127929611127929811E071-41247
chr10127929909127929990E071-41068
chr10127930219127930324E071-40734
chr10127930418127930468E071-40590
chr10127930574127932979E071-38079
chr10127923475127923525E072-47533
chr10127923528127923712E072-47346
chr10127923833127924159E072-46899
chr10127924233127924524E072-46534
chr10127924709127924768E072-46290
chr10127924833127924885E072-46173
chr10127925005127925075E072-45983
chr10127928647127928732E072-42326
chr10127928920127929545E072-41513
chr10127929611127929811E072-41247
chr10127929909127929990E072-41068
chr10127930219127930324E072-40734
chr10127930418127930468E072-40590
chr10127930574127932979E072-38079
chr10127975536127975610E0724478
chr10127975749127975909E0724691
chr10127975980127976030E0724922
chr10127976109127976186E0725051
chr10127922913127923055E073-48003
chr10127923279127923329E073-47729
chr10127923475127923525E073-47533
chr10127923528127923712E073-47346
chr10127923833127924159E073-46899
chr10127924233127924524E073-46534
chr10127924709127924768E073-46290
chr10127924833127924885E073-46173
chr10127928647127928732E073-42326
chr10127928920127929545E073-41513
chr10127929611127929811E073-41247
chr10127930574127932979E073-38079
chr10127975536127975610E0734478
chr10127975749127975909E0734691
chr10127975980127976030E0734922
chr10127923279127923329E074-47729
chr10127923475127923525E074-47533
chr10127923528127923712E074-47346
chr10127924709127924768E074-46290
chr10127924833127924885E074-46173
chr10127925005127925075E074-45983
chr10127928647127928732E074-42326
chr10127928920127929545E074-41513
chr10127929611127929811E074-41247
chr10127929909127929990E074-41068
chr10127930219127930324E074-40734
chr10127930418127930468E074-40590
chr10127930574127932979E074-38079
chr10127935304127935703E074-35355
chr10127975749127975909E0744691
chr10127975980127976030E0744922
chr10127976109127976186E0745051
chr10127990868127991915E07419810
chr10127922497127922726E081-48332
chr10127922913127923055E081-48003
chr10127923279127923329E081-47729
chr10127923475127923525E081-47533
chr10127923528127923712E081-47346
chr10127930574127932979E081-38079
chr10127922497127922726E082-48332
chr10127922913127923055E082-48003
chr10127923279127923329E082-47729
chr10127923475127923525E082-47533
chr10127923528127923712E082-47346