rs10797794

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0315 (9425/29908,GnomAD)
A=0288 (8403/29118,TOPMED)
A=0350 (1753/5008,1000G)
A=0413 (1593/3854,ALSPAC)
A=0404 (1497/3708,TWINSUK)

Position: chr1:182888873 (GRCh38.p7) (1q25.3)

Phenotype: CD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 40 Enhancers around

Promoter: 20 Promoters around

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.901	A=0.099
1000Genomes	American	Sub	694	G=0.550	A=0.450
1000Genomes	East Asian	Sub	1008	G=0.426	A=0.574
1000Genomes	Europe	Sub	1006	G=0.607	A=0.393
1000Genomes	Global	Study-wide	5008	G=0.650	A=0.350
1000Genomes	South Asian	Sub	978	G=0.660	A=0.340
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.587	A=0.413
The Genome Aggregation Database	African	Sub	8702	G=0.855	A=0.145
The Genome Aggregation Database	American	Sub	836	G=0.600	A=0.400
The Genome Aggregation Database	East Asian	Sub	1616	G=0.435	A=0.565
The Genome Aggregation Database	Europe	Sub	18452	G=0.631	A=0.368
The Genome Aggregation Database	Global	Study-wide	29908	G=0.684	A=0.315
The Genome Aggregation Database	Other	Sub	302	G=0.640	A=0.360
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.711	A=0.288
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.596	A=0.404

PMID	Title	Author	Journal
23958962	Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.	Gelernter J	Mol Psychiatry

SNP ID	p-value	Traits	Study
rs10797794	0.000119	cocaine dependence	23958962

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
Chr1:182858008	LAMC1	ENSG00000135862.5	G>A	2.1129e-17	-134587	Cerebellum

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

There is no significant Hi-C chromatin interaction data for this SNP.

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr1	182812593	182812642	E067	-45366
chr1	182812701	182812741	E067	-45267
chr1	182813060	182813114	E067	-44894
chr1	182814736	182814780	E067	-43228
chr1	182815161	182815267	E067	-42741
chr1	182824393	182824519	E067	-33489
chr1	182824756	182824854	E067	-33154
chr1	182812593	182812642	E068	-45366
chr1	182814736	182814780	E068	-43228
chr1	182859218	182859480	E068	1210
chr1	182859484	182859583	E068	1476
chr1	182813060	182813114	E069	-44894
chr1	182813476	182813516	E069	-44492
chr1	182814736	182814780	E069	-43228
chr1	182815161	182815267	E069	-42741
chr1	182812593	182812642	E070	-45366
chr1	182812701	182812741	E070	-45267
chr1	182813060	182813114	E070	-44894
chr1	182813476	182813516	E070	-44492
chr1	182814736	182814780	E070	-43228
chr1	182812593	182812642	E071	-45366
chr1	182814736	182814780	E071	-43228
chr1	182815161	182815267	E071	-42741
chr1	182812593	182812642	E072	-45366
chr1	182812701	182812741	E072	-45267
chr1	182813060	182813114	E072	-44894
chr1	182813476	182813516	E072	-44492
chr1	182814736	182814780	E072	-43228
chr1	182824756	182824854	E072	-33154
chr1	182814736	182814780	E073	-43228
chr1	182815161	182815267	E073	-42741
chr1	182824756	182824854	E073	-33154
chr1	182825134	182825362	E073	-32646
chr1	182814736	182814780	E074	-43228
chr1	182815161	182815267	E074	-42741
chr1	182859218	182859480	E074	1210
chr1	182859484	182859583	E074	1476
chr1	182813060	182813114	E082	-44894
chr1	182813476	182813516	E082	-44492
chr1	182895292	182895573	E082	37284

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr1	182809689	182809756	E067	-48252
chr1	182809837	182810000	E067	-48008
chr1	182809689	182809756	E068	-48252
chr1	182809837	182810000	E068	-48008
chr1	182809689	182809756	E069	-48252
chr1	182809837	182810000	E069	-48008
chr1	182809689	182809756	E070	-48252
chr1	182809837	182810000	E070	-48008
chr1	182809689	182809756	E071	-48252
chr1	182809837	182810000	E071	-48008
chr1	182809689	182809756	E072	-48252
chr1	182809837	182810000	E072	-48008
chr1	182809689	182809756	E073	-48252
chr1	182809837	182810000	E073	-48008
chr1	182809689	182809756	E074	-48252
chr1	182809837	182810000	E074	-48008
chr1	182809689	182809756	E081	-48252
chr1	182809837	182810000	E081	-48008
chr1	182809689	182809756	E082	-48252
chr1	182809837	182810000	E082	-48008