SNP Detail Info-rs10803574

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

LOC105373640 : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0356 (10650/29890,GnomAD)
A=0291 (8489/29118,TOPMED)
A=0271 (1357/5008,1000G)
A=0428 (1649/3854,ALSPAC)
A=0437 (1619/3708,TWINSUK)

Position: chr2:138953293 (GRCh38.p7) (2q22.1)

Phenotype: AD

Dataset:

GWASdb2

Publications: 3 publication(s)

Genomic View: See rs on genome

Enhancer: 0 Enhancer around

Promoter: 0 Promoter around

Sequence Name	Change(s)
GRCh38.p7 chr 2	NC_000002.12:g.138953293G>A
GRCh37.p13 chr 2	NC_000002.11:g.139710863G>A

Molecule type	Change	Amino acid[Codon]	SO Term
LOC105373640 transcript	XR_923371.2:n.	N/A	Intron Variant

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.900	A=0.100
1000Genomes	American	Sub	694	G=0.610	A=0.390
1000Genomes	East Asian	Sub	1008	G=0.697	A=0.303
1000Genomes	Europe	Sub	1006	G=0.601	A=0.399
1000Genomes	Global	Study-wide	5008	G=0.729	A=0.271
1000Genomes	South Asian	Sub	978	G=0.740	A=0.260
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.572	A=0.428
The Genome Aggregation Database	African	Sub	8704	G=0.857	A=0.143
The Genome Aggregation Database	American	Sub	832	G=0.610	A=0.390
The Genome Aggregation Database	East Asian	Sub	1616	G=0.734	A=0.266
The Genome Aggregation Database	Europe	Sub	18436	G=0.538	A=0.462
The Genome Aggregation Database	Global	Study-wide	29890	G=0.643	A=0.356
The Genome Aggregation Database	Other	Sub	302	G=0.570	A=0.430
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.708	A=0.291
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.563	A=0.437

PMID	Title	Author	Journal
21703634	A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.	Wang KS	J Psychiatr Res
20202923	A genome-wide association study of alcohol dependence.	Bierut LJ	Proc Natl Acad Sci U S A
21956439	Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.	Zuo L	Neuropsychopharmacology

SNP ID	p-value	Traits	Study
rs10803574	0.00000952	alcohol dependence	21703634
rs10803574	0.00018	alcohol dependence	21956439

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

rs10803574