rs10808358

Homo sapiens
G>A
POP1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0414 (12372/29882,GnomAD)
A=0435 (12674/29118,TOPMED)
A=0418 (2092/5008,1000G)
A=0413 (1590/3854,ALSPAC)
A=0427 (1584/3708,TWINSUK)
chr8:98124925 (GRCh38.p7) (8q22.2)
AD
GWASdb2
1   publication(s)
See rs on genome
141 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.98124925G>A
GRCh37.p13 chr 8NC_000008.10:g.99137153G>A

Gene: POP1, POP1 homolog, ribonuclease P/MRP subunit(plus strand)

Molecule type Change Amino acid[Codon] SO Term
POP1 transcript variant 1NM_001145860.1:c.N/AIntron Variant
POP1 transcript variant 2NM_001145861.1:c.N/AIntron Variant
POP1 transcript variant 3NM_015029.2:c.N/AIntron Variant
POP1 transcript variant X1XM_011516801.2:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.551A=0.449
1000GenomesAmericanSub694G=0.570A=0.430
1000GenomesEast AsianSub1008G=0.710A=0.290
1000GenomesEuropeSub1006G=0.568A=0.432
1000GenomesGlobalStudy-wide5008G=0.582A=0.418
1000GenomesSouth AsianSub978G=0.510A=0.490
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.587A=0.413
The Genome Aggregation DatabaseAfricanSub8684G=0.557A=0.443
The Genome Aggregation DatabaseAmericanSub836G=0.550A=0.450
The Genome Aggregation DatabaseEast AsianSub1612G=0.764A=0.236
The Genome Aggregation DatabaseEuropeSub18448G=0.587A=0.412
The Genome Aggregation DatabaseGlobalStudy-wide29882G=0.586A=0.414
The Genome Aggregation DatabaseOtherSub302G=0.460A=0.540
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.564A=0.435
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.573A=0.427
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs108083580.000384alcohol dependence20201924

eQTL of rs10808358 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10808358 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr89913188299131954E067-5199
chr89913210499132165E067-4988
chr89913221099132270E067-4883
chr89913230299132352E067-4801
chr89914452599144575E0677372
chr89916657999166629E06729426
chr89916672899166778E06729575
chr89916680399166905E06729650
chr89916940799169457E06732254
chr89916955299169653E06732399
chr89916980099169937E06732647
chr89916998699170523E06732833
chr89917148999171598E06734336
chr89917184399171897E06734690
chr89917194499172027E06734791
chr89917209399172506E06734940
chr89917254899172672E06735395
chr89917650099177702E06739347
chr89917774899177879E06740595
chr89918280399183140E06745650
chr89918318599183261E06746032
chr89918332999183424E06746176
chr89914480099144936E0687647
chr89914498899145032E0687835
chr89916657999166629E06829426
chr89916998699170523E06832833
chr89917068099170832E06833527
chr89917096599171018E06833812
chr89917105799171128E06833904
chr89917148999171598E06834336
chr89917184399171897E06834690
chr89917194499172027E06834791
chr89917590599176375E06838752
chr89917650099177702E06839347
chr89917774899177879E06840595
chr89913084299130892E069-6261
chr89913142199131483E069-5670
chr89913159499131663E069-5490
chr89913188299131954E069-5199
chr89916563699165755E06928483
chr89916657999166629E06929426
chr89916672899166778E06929575
chr89916680399166905E06929650
chr89916998699170523E06932833
chr89917068099170832E06933527
chr89917096599171018E06933812
chr89917105799171128E06933904
chr89917148999171598E06934336
chr89917184399171897E06934690
chr89917194499172027E06934791
chr89917209399172506E06934940
chr89917254899172672E06935395
chr89917650099177702E06939347
chr89917774899177879E06940595
chr89918193299182004E06944779
chr89913106899131120E070-6033
chr89914372099143816E0706567
chr89914390299143982E0706749
chr89914408699144180E0706933
chr89914452599144575E0707372
chr89914480099144936E0707647
chr89918280399183140E07045650
chr89909767499098212E071-38941
chr89913084299130892E071-6261
chr89914452599144575E0717372
chr89916657999166629E07129426
chr89916672899166778E07129575
chr89916680399166905E07129650
chr89916980099169937E07132647
chr89917068099170832E07133527
chr89917096599171018E07133812
chr89917105799171128E07133904
chr89917148999171598E07134336
chr89917184399171897E07134690
chr89917194499172027E07134791
chr89917209399172506E07134940
chr89917650099177702E07139347
chr89917774899177879E07140595
chr89918280399183140E07145650
chr89913084299130892E072-6261
chr89913106899131120E072-6033
chr89914480099144936E0727647
chr89916435899164525E07227205
chr89916454399165025E07227390
chr89916512199165171E07227968
chr89916657999166629E07229426
chr89916672899166778E07229575
chr89916680399166905E07229650
chr89916725899167392E07230105
chr89916980099169937E07232647
chr89916998699170523E07232833
chr89917068099170832E07233527
chr89917096599171018E07233812
chr89917105799171128E07233904
chr89917148999171598E07234336
chr89917184399171897E07234690
chr89917194499172027E07234791
chr89917209399172506E07234940
chr89917254899172672E07235395
chr89917650099177702E07239347
chr89917774899177879E07240595
chr89914480099144936E0737647
chr89916657999166629E07329426
chr89916672899166778E07329575
chr89916680399166905E07329650
chr89916725899167392E07330105
chr89916980099169937E07332647
chr89916998699170523E07332833
chr89917148999171598E07334336
chr89917184399171897E07334690
chr89917194499172027E07334791
chr89917209399172506E07334940
chr89917254899172672E07335395
chr89917650099177702E07339347
chr89917774899177879E07340595
chr89918280399183140E07345650
chr89918318599183261E07346032
chr89913084299130892E074-6261
chr89914480099144936E0747647
chr89916603099166097E07428877
chr89916657999166629E07429426
chr89916672899166778E07429575
chr89916680399166905E07429650
chr89916980099169937E07432647
chr89917068099170832E07433527
chr89917096599171018E07433812
chr89917105799171128E07433904
chr89917148999171598E07434336
chr89917184399171897E07434690
chr89917194499172027E07434791
chr89917209399172506E07434940
chr89917590599176375E07438752
chr89917650099177702E07439347
chr89917774899177879E07440595
chr89918193299182004E07444779
chr89913084299130892E081-6261
chr89918280399183140E08145650
chr89918318599183261E08146032
chr89913106899131120E082-6033
chr89918280399183140E08245650
chr89918318599183261E08246032










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr89912850099130594E067-6559
chr89912850099130594E068-6559
chr89912850099130594E069-6559
chr89912850099130594E070-6559
chr89912850099130594E071-6559
chr89912850099130594E072-6559
chr89912850099130594E073-6559
chr89912850099130594E074-6559
chr89912850099130594E081-6559
chr89912850099130594E082-6559