rs10810935

Organism: Homo sapiens

Alleles: A>G / A>T

Gene : Feature

ADAMTSL1 : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G=0192 (5770/29934,GnomAD)
G=0177 (5169/29118,TOPMED)
G=0179 (895/5008,1000G)
G=0264 (1017/3854,ALSPAC)
G=0255 (945/3708,TWINSUK)

Position: chr9:18251857 (GRCh38.p7) (9p22.2)

Phenotype: AD

Dataset:

GWASdb2 | GWASCatalog

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 0 Enhancer around

Promoter: 0 Promoter around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 9	NC_000009.12:g.18251857A>G
GRCh38.p7 chr 9	NC_000009.12:g.18251857A>T
GRCh37.p13 chr 9	NC_000009.11:g.18251855A>G
GRCh37.p13 chr 9	NC_000009.11:g.18251855A>T

Gene: ADAMTSL1, ADAMTS like 1(plus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
ADAMTSL1 transcript variant 4	NM_001040272.5:c.	N/A	Genic Upstream Transcript Variant
ADAMTSL1 transcript variant 2	NM_052866.4:c.	N/A	Genic Upstream Transcript Variant
ADAMTSL1 transcript variant X1	XM_011518063.2:c.	N/A	Intron Variant
ADAMTSL1 transcript variant X3	XM_011518064.2:c.	N/A	Intron Variant
ADAMTSL1 transcript variant X2	XM_017015310.1:c.	N/A	Intron Variant
ADAMTSL1 transcript variant X4	XM_017015311.1:c.	N/A	Intron Variant
ADAMTSL1 transcript variant X5	XM_017015312.1:c.	N/A	Intron Variant
ADAMTSL1 transcript variant X7	XM_017015314.1:c.	N/A	Intron Variant
ADAMTSL1 transcript variant X8	XM_011518067.1:c.	N/A	Genic Upstream Transcript Variant
ADAMTSL1 transcript variant X9	XM_011518068.2:c.	N/A	Genic Upstream Transcript Variant
ADAMTSL1 transcript variant X10	XM_011518070.2:c.	N/A	Genic Upstream Transcript Variant
ADAMTSL1 transcript variant X6	XM_017015313.1:c.	N/A	Genic Upstream Transcript Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.963	G=0.037
1000Genomes	American	Sub	694	A=0.840	G=0.160
1000Genomes	East Asian	Sub	1008	A=0.755	G=0.245
1000Genomes	Europe	Sub	1006	A=0.719	G=0.281
1000Genomes	Global	Study-wide	5008	A=0.821	G=0.179
1000Genomes	South Asian	Sub	978	A=0.790	G=0.210
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.736	G=0.264
The Genome Aggregation Database	African	Sub	8726	A=0.926	T=0.001
The Genome Aggregation Database	American	Sub	836	A=0.840	T=0.00,
The Genome Aggregation Database	East Asian	Sub	1614	A=0.772	T=0.000
The Genome Aggregation Database	Europe	Sub	18458	A=0.754	T=0.000
The Genome Aggregation Database	Global	Study-wide	29934	A=0.807	T=0.000
The Genome Aggregation Database	Other	Sub	300	A=0.690	T=0.00,
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.822	G=0.177
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.745	G=0.255

PMID	Title	Author	Journal
24962325	Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.	Kapoor M	Drug Alcohol Depend

P-Value

SNP ID	p-value	Traits	Study
rs10810935	2E-06	alcohol dependence (age at onset)	24962325

eQTL of rs10810935 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs10810935 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.