rs10812450

Homo sapiens
C>T
LOC105376000 : Non Coding Transcript Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0304 (9104/29884,GnomAD)
T=0322 (9377/29118,TOPMED)
T=0286 (1434/5008,1000G)
T=0310 (1195/3854,ALSPAC)
T=0317 (1177/3708,TWINSUK)
chr9:26722840 (GRCh38.p7) (9p21.2)
AD
GWASdb2
1   publication(s)
See rs on genome
30 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 9NC_000009.12:g.26722840C>T
GRCh37.p13 chr 9NC_000009.11:g.26722838C>T

Gene: LOC105376000, uncharacterized LOC105376000(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105376000 transcriptXR_001746638.1:n....XR_001746638.1:n.1303G>AG>ANon Coding Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.687T=0.313
1000GenomesAmericanSub694C=0.770T=0.230
1000GenomesEast AsianSub1008C=0.897T=0.103
1000GenomesEuropeSub1006C=0.659T=0.341
1000GenomesGlobalStudy-wide5008C=0.714T=0.286
1000GenomesSouth AsianSub978C=0.580T=0.420
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.690T=0.310
The Genome Aggregation DatabaseAfricanSub8710C=0.679T=0.321
The Genome Aggregation DatabaseAmericanSub836C=0.800T=0.200
The Genome Aggregation DatabaseEast AsianSub1616C=0.893T=0.107
The Genome Aggregation DatabaseEuropeSub18420C=0.683T=0.316
The Genome Aggregation DatabaseGlobalStudy-wide29884C=0.695T=0.304
The Genome Aggregation DatabaseOtherSub302C=0.550T=0.450
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.678T=0.322
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.683T=0.317
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs108124500.00076alcohol dependence20201924

eQTL of rs10812450 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10812450 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr92672311626723166E068278
chr92672416326724213E0681325
chr92675414026754391E06831302
chr92675440926754561E06831571
chr92675463026754841E06831792
chr92675463026754841E06931792
chr92675484826755137E06932010
chr92675519626755376E06932358
chr92672154726721616E070-1222
chr92672180526721918E070-920
chr92672212226722172E070-666
chr92672234926722399E070-439
chr92672256226722713E070-125
chr92672311626723166E070278
chr92672328726723337E070449
chr92674273526742923E07019897
chr92674294326743162E07020105
chr92674338126743431E07020543
chr92674345526743515E07020617
chr92675463026754841E07031792
chr92675484826755137E07032010
chr92675519626755376E07032358
chr92675596526756005E07033127
chr92672256226722713E071-125
chr92669413926694234E081-28604
chr92669437726694467E081-28371
chr92669497926695158E081-27680
chr92669526326695623E081-27215
chr92669562726695677E081-27161
chr92672256226722713E082-125