rs10821008

Homo sapiens
G>A
BICD2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0374 (11199/29898,GnomAD)
A=0458 (13351/29118,TOPMED)
A=0328 (1641/5008,1000G)
A=0289 (1112/3854,ALSPAC)
A=0304 (1127/3708,TWINSUK)
chr9:92725215 (GRCh38.p7) (9q22.31)
AD
GWASdb2
1   publication(s)
See rs on genome
434 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 9NC_000009.12:g.92725215G>A
GRCh37.p13 chr 9NC_000009.11:g.95487497G>A
BICD2 RefSeqGeneNG_033908.1:g.44587C>T

Gene: BICD2, BICD cargo adaptor 2(minus strand)

Molecule type Change Amino acid[Codon] SO Term
BICD2 transcript variant 1NM_001003800.1:c.N/AIntron Variant
BICD2 transcript variant 2NM_015250.3:c.N/AIntron Variant
BICD2 transcript variant X1XM_017014551.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.276A=0.724
1000GenomesAmericanSub694G=0.760A=0.240
1000GenomesEast AsianSub1008G=0.899A=0.101
1000GenomesEuropeSub1006G=0.703A=0.297
1000GenomesGlobalStudy-wide5008G=0.672A=0.328
1000GenomesSouth AsianSub978G=0.880A=0.120
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.711A=0.289
The Genome Aggregation DatabaseAfricanSub8680G=0.360A=0.640
The Genome Aggregation DatabaseAmericanSub838G=0.770A=0.230
The Genome Aggregation DatabaseEast AsianSub1620G=0.912A=0.088
The Genome Aggregation DatabaseEuropeSub18458G=0.718A=0.281
The Genome Aggregation DatabaseGlobalStudy-wide29898G=0.625A=0.374
The Genome Aggregation DatabaseOtherSub302G=0.630A=0.370
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.541A=0.458
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.696A=0.304
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs108210080.000679alcohol dependence21314694

eQTL of rs10821008 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr9:95487497CENPPENSG00000188312.9G>A1.5165e-20399578Cerebellum
Chr9:95487497IPPKENSG00000127080.5G>A6.5253e-754950Cerebellum
Chr9:95487497CENPPENSG00000188312.9G>A1.5704e-16399578Frontal_Cortex_BA9
Chr9:95487497CENPPENSG00000188312.9G>A5.0201e-18399578Cortex
Chr9:95487497CENPPENSG00000188312.9G>A1.9464e-18399578Cerebellar_Hemisphere
Chr9:95487497IPPKENSG00000127080.5G>A1.4337e-654950Cerebellar_Hemisphere
Chr9:95487497CENPPENSG00000188312.9G>A2.8739e-16399578Caudate_basal_ganglia
Chr9:95487497CENPPENSG00000188312.9G>A1.0289e-11399578Anterior_cingulate_cortex
Chr9:95487497CENPPENSG00000188312.9G>A1.3039e-18399578Nucleus_accumbens_basal_ganglia

meQTL of rs10821008 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr99548413795484247E067-3250
chr99548425995484360E067-3137
chr99548459695484646E067-2851
chr99548494195485365E067-2132
chr99548541395485949E067-1548
chr99548600395486078E067-1419
chr99548983895489942E0672341
chr99549145795491699E0673960
chr99549172995491965E0674232
chr99549197195492041E0674474
chr99549212295492336E0674625
chr99549892895499095E06711431
chr99549931695500175E06711819
chr99550019895500275E06712701
chr99550041695500529E06712919
chr99550057695500666E06713079
chr99550071495501557E06713217
chr99550160095501876E06714103
chr99550190695502169E06714409
chr99550221695502268E06714719
chr99550233295503756E06714835
chr99550739795507502E06719900
chr99550751295507578E06720015
chr99550768995507750E06720192
chr99550784395507989E06720346
chr99550885295509445E06721355
chr99550962095510777E06722123
chr99551122595511265E06723728
chr99551141595512519E06723918
chr99551259895512717E06725101
chr99551829995518497E06730802
chr99552198695522109E06734489
chr99552227295522516E06734775
chr99552252995522761E06735032
chr99552287995523021E06735382
chr99552307395523123E06735576
chr99552331995523572E06735822
chr99552363595523686E06736138
chr99552371695523884E06736219
chr99552391095523990E06736413
chr99548494195485365E068-2132
chr99548541395485949E068-1548
chr99548600395486078E068-1419
chr99548609095486687E068-810
chr99548677295486843E068-654
chr99548689595486952E068-545
chr99548698195487050E068-447
chr99548708695487246E068-251
chr99548742195487494E068-3
chr99548753895487604E06841
chr99548766995487797E068172
chr99548877395488830E0681276
chr99548907795489668E0681580
chr99549172995491965E0684232
chr99549197195492041E0684474
chr99549212295492336E0684625
chr99549279295492964E0685295
chr99549313195493188E0685634
chr99549346495493541E0685967
chr99549362895493686E0686131
chr99549397595494029E0686478
chr99549406295494169E0686565
chr99549437495494436E0686877
chr99549448295494629E0686985
chr99549931695500175E06811819
chr99550019895500275E06812701
chr99550041695500529E06812919
chr99550057695500666E06813079
chr99550071495501557E06813217
chr99550160095501876E06814103
chr99550190695502169E06814409
chr99550221695502268E06814719
chr99550233295503756E06814835
chr99550498595505357E06817488
chr99550751295507578E06820015
chr99550768995507750E06820192
chr99550885295509445E06821355
chr99550962095510777E06822123
chr99551122595511265E06823728
chr99551141595512519E06823918
chr99551259895512717E06825101
chr99551292295512972E06825425
chr99552003595520115E06832538
chr99552012195520171E06832624
chr99552136595521415E06833868
chr99552148095521547E06833983
chr99552198695522109E06834489
chr99552227295522516E06834775
chr99552252995522761E06835032
chr99552287995523021E06835382
chr99552307395523123E06835576
chr99552331995523572E06835822
chr99552363595523686E06836138
chr99552371695523884E06836219
chr99552391095523990E06836413
chr99553233595533288E06844838
chr99553668595536855E06849188
chr99548541395485949E069-1548
chr99548600395486078E069-1419
chr99548609095486687E069-810
chr99548677295486843E069-654
chr99548689595486952E069-545
chr99548698195487050E069-447
chr99548708695487246E069-251
chr99548907795489668E0691580
chr99548983895489942E0692341
chr99549000795490057E0692510
chr99549039995490459E0692902
chr99549048595490581E0692988
chr99549084595490903E0693348
chr99549099195491041E0693494
chr99549105695491451E0693559
chr99549145795491699E0693960
chr99549172995491965E0694232
chr99549197195492041E0694474
chr99549212295492336E0694625
chr99549279295492964E0695295
chr99549313195493188E0695634
chr99549346495493541E0695967
chr99549720395497555E0699706
chr99549757695498543E06910079
chr99549892895499095E06911431
chr99549931695500175E06911819
chr99550019895500275E06912701
chr99550041695500529E06912919
chr99550057695500666E06913079
chr99550071495501557E06913217
chr99550160095501876E06914103
chr99550190695502169E06914409
chr99550221695502268E06914719
chr99550233295503756E06914835
chr99550739795507502E06919900
chr99550751295507578E06920015
chr99550768995507750E06920192
chr99550784395507989E06920346
chr99550813195508181E06920634
chr99550823495508348E06920737
chr99550838995508500E06920892
chr99550885295509445E06921355
chr99550962095510777E06922123
chr99551122595511265E06923728
chr99551141595512519E06923918
chr99551259895512717E06925101
chr99551292295512972E06925425
chr99552198695522109E06934489
chr99552227295522516E06934775
chr99552252995522761E06935032
chr99552287995523021E06935382
chr99552307395523123E06935576
chr99552331995523572E06935822
chr99552363595523686E06936138
chr99552371695523884E06936219
chr99552391095523990E06936413
chr99548600395486078E070-1419
chr99549757695498543E07010079
chr99550019895500275E07012701
chr99550041695500529E07012919
chr99550057695500666E07013079
chr99550071495501557E07013217
chr99550160095501876E07014103
chr99550190695502169E07014409
chr99550221695502268E07014719
chr99550233295503756E07014835
chr99550394195504001E07016444
chr99550723295507313E07019735
chr99550739795507502E07019900
chr99550751295507578E07020015
chr99550768995507750E07020192
chr99550784395507989E07020346
chr99550813195508181E07020634
chr99550823495508348E07020737
chr99550838995508500E07020892
chr99550962095510777E07022123
chr99551292295512972E07025425
chr99551315495513208E07025657
chr99552136595521415E07033868
chr99552148095521547E07033983
chr99548541395485949E071-1548
chr99548600395486078E071-1419
chr99548609095486687E071-810
chr99548677295486843E071-654
chr99548689595486952E071-545
chr99548698195487050E071-447
chr99548708695487246E071-251
chr99548907795489668E0711580
chr99548983895489942E0712341
chr99549145795491699E0713960
chr99549172995491965E0714232
chr99549197195492041E0714474
chr99549212295492336E0714625
chr99549279295492964E0715295
chr99549313195493188E0715634
chr99549346495493541E0715967
chr99549757695498543E07110079
chr99549858995498714E07111092
chr99549892895499095E07111431
chr99549931695500175E07111819
chr99550019895500275E07112701
chr99550041695500529E07112919
chr99550057695500666E07113079
chr99550071495501557E07113217
chr99550160095501876E07114103
chr99550190695502169E07114409
chr99550221695502268E07114719
chr99550233295503756E07114835
chr99550394195504001E07116444
chr99550487695504916E07117379
chr99550498595505357E07117488
chr99550571095505760E07118213
chr99550588795505927E07118390
chr99550592995506052E07118432
chr99550608195506295E07118584
chr99550635295506424E07118855
chr99550654695506598E07119049
chr99550662795506667E07119130
chr99550723295507313E07119735
chr99550739795507502E07119900
chr99550751295507578E07120015
chr99550768995507750E07120192
chr99550784395507989E07120346
chr99550813195508181E07120634
chr99550823495508348E07120737
chr99550838995508500E07120892
chr99550962095510777E07122123
chr99551122595511265E07123728
chr99551259895512717E07125101
chr99551292295512972E07125425
chr99551919995519401E07131702
chr99551967595519931E07132178
chr99552003595520115E07132538
chr99552012195520171E07132624
chr99552136595521415E07133868
chr99552148095521547E07133983
chr99552198695522109E07134489
chr99552227295522516E07134775
chr99552252995522761E07135032
chr99552287995523021E07135382
chr99552307395523123E07135576
chr99552331995523572E07135822
chr99552363595523686E07136138
chr99552371695523884E07136219
chr99552391095523990E07136413
chr99553233595533288E07144838
chr99553668595536855E07149188
chr99548494195485365E072-2132
chr99548541395485949E072-1548
chr99548600395486078E072-1419
chr99548609095486687E072-810
chr99548677295486843E072-654
chr99548689595486952E072-545
chr99548698195487050E072-447
chr99548708695487246E072-251
chr99548742195487494E072-3
chr99548753895487604E07241
chr99548766995487797E072172
chr99549099195491041E0723494
chr99549105695491451E0723559
chr99549145795491699E0723960
chr99549172995491965E0724232
chr99549197195492041E0724474
chr99549212295492336E0724625
chr99549279295492964E0725295
chr99549313195493188E0725634
chr99549346495493541E0725967
chr99549931695500175E07211819
chr99550019895500275E07212701
chr99550041695500529E07212919
chr99550057695500666E07213079
chr99550071495501557E07213217
chr99550160095501876E07214103
chr99550190695502169E07214409
chr99550221695502268E07214719
chr99550233295503756E07214835
chr99550739795507502E07219900
chr99550751295507578E07220015
chr99550768995507750E07220192
chr99550784395507989E07220346
chr99550813195508181E07220634
chr99550823495508348E07220737
chr99550838995508500E07220892
chr99550885295509445E07221355
chr99550962095510777E07222123
chr99551141595512519E07223918
chr99551292295512972E07225425
chr99551919995519401E07231702
chr99551967595519931E07232178
chr99552003595520115E07232538
chr99552012195520171E07232624
chr99552198695522109E07234489
chr99552227295522516E07234775
chr99552252995522761E07235032
chr99552287995523021E07235382
chr99552307395523123E07235576
chr99552331995523572E07235822
chr99552363595523686E07236138
chr99552371695523884E07236219
chr99552391095523990E07236413
chr99548494195485365E073-2132
chr99548541395485949E073-1548
chr99548600395486078E073-1419
chr99548609095486687E073-810
chr99548677295486843E073-654
chr99548907795489668E0731580
chr99548983895489942E0732341
chr99549000795490057E0732510
chr99549039995490459E0732902
chr99549048595490581E0732988
chr99549084595490903E0733348
chr99549099195491041E0733494
chr99549105695491451E0733559
chr99549145795491699E0733960
chr99549172995491965E0734232
chr99549197195492041E0734474
chr99549212295492336E0734625
chr99549279295492964E0735295
chr99549313195493188E0735634
chr99549346495493541E0735967
chr99549858995498714E07311092
chr99549892895499095E07311431
chr99549931695500175E07311819
chr99550019895500275E07312701
chr99550041695500529E07312919
chr99550057695500666E07313079
chr99550071495501557E07313217
chr99550160095501876E07314103
chr99550190695502169E07314409
chr99550221695502268E07314719
chr99550233295503756E07314835
chr99550739795507502E07319900
chr99550751295507578E07320015
chr99550768995507750E07320192
chr99550784395507989E07320346
chr99550813195508181E07320634
chr99550823495508348E07320737
chr99550838995508500E07320892
chr99550885295509445E07321355
chr99550962095510777E07322123
chr99551122595511265E07323728
chr99551141595512519E07323918
chr99551259895512717E07325101
chr99552003595520115E07332538
chr99552012195520171E07332624
chr99552198695522109E07334489
chr99552227295522516E07334775
chr99552252995522761E07335032
chr99552287995523021E07335382
chr99552307395523123E07335576
chr99552331995523572E07335822
chr99552363595523686E07336138
chr99552371695523884E07336219
chr99552391095523990E07336413
chr99546871895469159E074-18338
chr99548494195485365E074-2132
chr99548541395485949E074-1548
chr99548600395486078E074-1419
chr99548609095486687E074-810
chr99548677295486843E074-654
chr99548742195487494E074-3
chr99549145795491699E0743960
chr99549172995491965E0744232
chr99549197195492041E0744474
chr99549212295492336E0744625
chr99549757695498543E07410079
chr99549858995498714E07411092
chr99549892895499095E07411431
chr99549931695500175E07411819
chr99550019895500275E07412701
chr99550041695500529E07412919
chr99550057695500666E07413079
chr99550071495501557E07413217
chr99550160095501876E07414103
chr99550190695502169E07414409
chr99550221695502268E07414719
chr99550233295503756E07414835
chr99550739795507502E07419900
chr99550751295507578E07420015
chr99550768995507750E07420192
chr99550784395507989E07420346
chr99550813195508181E07420634
chr99550823495508348E07420737
chr99550838995508500E07420892
chr99550885295509445E07421355
chr99550962095510777E07422123
chr99551122595511265E07423728
chr99551141595512519E07423918
chr99551292295512972E07425425
chr99551829995518497E07430802
chr99552003595520115E07432538
chr99552012195520171E07432624
chr99552136595521415E07433868
chr99552148095521547E07433983
chr99552198695522109E07434489
chr99552227295522516E07434775
chr99552252995522761E07435032
chr99552287995523021E07435382
chr99552307395523123E07435576
chr99552331995523572E07435822
chr99552363595523686E07436138
chr99552371695523884E07436219
chr99552391095523990E07436413
chr99549172995491965E0814232
chr99549197195492041E0814474
chr99549212295492336E0814625
chr99550160095501876E08114103
chr99550190695502169E08114409
chr99551122595511265E08123728
chr99551141595512519E08123918
chr99552198695522109E08134489
chr99552227295522516E08134775
chr99552252995522761E08135032
chr99552287995523021E08135382
chr99552307395523123E08135576
chr99552331995523572E08135822
chr99552363595523686E08136138
chr99552371695523884E08136219
chr99552391095523990E08136413
chr99549145795491699E0823960
chr99549172995491965E0824232
chr99549197195492041E0824474
chr99549212295492336E0824625
chr99550071495501557E08213217
chr99550160095501876E08214103
chr99550190695502169E08214409
chr99551141595512519E08223918
chr99552198695522109E08234489
chr99552227295522516E08234775
chr99552252995522761E08235032
chr99552287995523021E08235382
chr99552307395523123E08235576
chr99552331995523572E08235822
chr99552363595523686E08236138
chr99552371695523884E08236219
chr99552391095523990E08236413
chr99553668595536855E08249188










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr99552406195528315E06736564
chr99552406195528315E06836564
chr99552406195528315E06936564
chr99552406195528315E07036564
chr99552406195528315E07136564
chr99552406195528315E07236564
chr99552406195528315E07336564
chr99552406195528315E07436564
chr99552406195528315E08136564
chr99552406195528315E08236564