rs10824650

Homo sapiens
A>G
LOC105378305 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0411 (12241/29730,GnomAD)
G=0373 (10882/29118,TOPMED)
G=0446 (2235/5008,1000G)
A==0456 (1756/3854,ALSPAC)
A==0468 (1737/3708,TWINSUK)
chr10:52602138 (GRCh38.p7) (10q21.1)
AD
GWASdb2
1   publication(s)
See rs on genome
46 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.52602138A>G
GRCh37.p13 chr 10NC_000010.10:g.54361898A>G

Gene: LOC105378305, uncharacterized LOC105378305(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105378305 transcript variant X3XR_001747449.1:n.N/AIntron Variant
LOC105378305 transcript variant X4XR_001747450.1:n.N/AIntron Variant
LOC105378305 transcript variant X2XR_945961.2:n.N/AIntron Variant
LOC105378305 transcript variant X1XR_945962.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.895G=0.105
1000GenomesAmericanSub694A=0.560G=0.440
1000GenomesEast AsianSub1008A=0.477G=0.523
1000GenomesEuropeSub1006A=0.445G=0.555
1000GenomesGlobalStudy-wide5008A=0.554G=0.446
1000GenomesSouth AsianSub978A=0.280G=0.720
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.456G=0.544
The Genome Aggregation DatabaseAfricanSub8710A=0.819G=0.181
The Genome Aggregation DatabaseAmericanSub830A=0.600G=0.400
The Genome Aggregation DatabaseEast AsianSub1614A=0.498G=0.502
The Genome Aggregation DatabaseEuropeSub18274A=0.489G=0.510
The Genome Aggregation DatabaseGlobalStudy-wide29730A=0.588G=0.411
The Genome Aggregation DatabaseOtherSub302A=0.370G=0.630
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.626G=0.373
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.468G=0.532
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs108246500.000877alcohol dependence20201924

eQTL of rs10824650 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10824650 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr105440432154404451E06742423
chr105440448954404792E06742591
chr105440508054405330E06743182
chr105440533854405547E06743440
chr105441072454410815E06748826
chr105441084454410925E06748946
chr105441113154411319E06749233
chr105441135554411482E06749457
chr105440508054405330E06843182
chr105440533854405547E06843440
chr105441113154411319E06849233
chr105441135554411482E06849457
chr105438823154388461E06926333
chr105440432154404451E06942423
chr105440448954404792E06942591
chr105440508054405330E06943182
chr105440533854405547E06943440
chr105441072454410815E06948826
chr105441084454410925E06948946
chr105441113154411319E06949233
chr105441135554411482E06949457
chr105440448954404792E07042591
chr105440508054405330E07043182
chr105441113154411319E07049233
chr105441135554411482E07049457
chr105440508054405330E07143182
chr105440533854405547E07143440
chr105441072454410815E07148826
chr105441084454410925E07148946
chr105441113154411319E07149233
chr105441135554411482E07149457
chr105438823154388461E07226333
chr105440448954404792E07242591
chr105440508054405330E07243182
chr105440533854405547E07243440
chr105441113154411319E07249233
chr105441135554411482E07249457
chr105441113154411319E07349233
chr105441135554411482E07349457
chr105438823154388461E07426333
chr105440508054405330E07443182
chr105440533854405547E07443440
chr105441072454410815E07448826
chr105441084454410925E07448946
chr105441113154411319E07449233
chr105441135554411482E07449457