rs10846616

Homo sapiens
A>C
ZNF664-FAM101A : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0279 (8360/29926,GnomAD)
C=0252 (7355/29118,TOPMED)
C=0309 (1549/5008,1000G)
C=0294 (1134/3854,ALSPAC)
C=0285 (1056/3708,TWINSUK)
chr12:124176393 (GRCh38.p7) (12q24.31)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 12NC_000012.12:g.124176393A>C
GRCh37.p13 chr 12NC_000012.11:g.124660939A>C

Gene: ZNF664-FAM101A, filamin-interacting protein FAM101A(plus strand)

Molecule type Change Amino acid[Codon] SO Term
ZNF664-FAM101A transcriptNM_001204299.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.728C=0.272
1000GenomesAmericanSub694A=0.700C=0.300
1000GenomesEast AsianSub1008A=0.544C=0.456
1000GenomesEuropeSub1006A=0.716C=0.284
1000GenomesGlobalStudy-wide5008A=0.691C=0.309
1000GenomesSouth AsianSub978A=0.760C=0.240
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.706C=0.294
The Genome Aggregation DatabaseAfricanSub8704A=0.775C=0.225
The Genome Aggregation DatabaseAmericanSub836A=0.640C=0.360
The Genome Aggregation DatabaseEast AsianSub1614A=0.499C=0.501
The Genome Aggregation DatabaseEuropeSub18470A=0.716C=0.283
The Genome Aggregation DatabaseGlobalStudy-wide29926A=0.720C=0.279
The Genome Aggregation DatabaseOtherSub302A=0.790C=0.210
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.747C=0.252
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.715C=0.285
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs108466160.000658alcohol consumption (maxi-drinks)24277619

eQTL of rs10846616 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10846616 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr12124637056124637326E067-23613
chr12124637365124637601E067-23338
chr12124672539124673076E06711600
chr12124673091124673593E06712152
chr12124673964124674025E06713025
chr12124674048124674152E06713109
chr12124673091124673593E06812152
chr12124673608124673706E06812669
chr12124673765124673840E06812826
chr12124674753124674803E06813814
chr12124702877124702956E06841938
chr12124703315124703642E06842376
chr12124634457124634686E069-26253
chr12124634787124635020E069-25919
chr12124644217124645197E069-15742
chr12124660110124660160E069-779
chr12124673765124673840E06912826
chr12124673964124674025E06913025
chr12124674048124674152E06913109
chr12124674181124674237E06913242
chr12124674298124674428E06913359
chr12124674753124674803E06913814
chr12124674885124675269E06913946
chr12124644217124645197E070-15742
chr12124645550124645787E070-15152
chr12124658607124660053E070-886
chr12124660110124660160E070-779
chr12124660178124660918E070-21
chr12124675525124675576E07014586
chr12124675588124675823E07014649
chr12124675914124676002E07014975
chr12124701855124701922E07040916
chr12124701993124702692E07041054
chr12124634457124634686E071-26253
chr12124634787124635020E071-25919
chr12124644217124645197E071-15742
chr12124672539124673076E07111600
chr12124673091124673593E07112152
chr12124701855124701922E07140916
chr12124634323124634373E072-26566
chr12124634457124634686E072-26253
chr12124634787124635020E072-25919
chr12124672539124673076E07211600
chr12124673091124673593E07212152
chr12124673608124673706E07212669
chr12124673765124673840E07212826
chr12124660110124660160E073-779
chr12124672539124673076E07311600
chr12124673091124673593E07312152
chr12124673608124673706E07312669
chr12124673765124673840E07312826
chr12124673964124674025E07313025
chr12124637056124637326E074-23613
chr12124637365124637601E074-23338
chr12124678925124680191E07417986
chr12124631690124631857E081-29082
chr12124631894124632556E081-28383
chr12124634787124635020E081-25919
chr12124635188124635238E081-25701
chr12124636643124636760E081-24179
chr12124636807124636881E081-24058
chr12124636948124637010E081-23929
chr12124637056124637326E081-23613
chr12124637365124637601E081-23338
chr12124644217124645197E081-15742
chr12124652417124652480E081-8459
chr12124652508124652552E081-8387
chr12124652689124652918E081-8021
chr12124652922124653240E081-7699
chr12124658124124658225E081-2714
chr12124658263124658400E081-2539
chr12124658607124660053E081-886
chr12124660110124660160E081-779
chr12124660178124660918E081-21
chr12124661120124661170E081181
chr12124661224124661345E081285
chr12124661394124661444E081455
chr12124661659124661784E081720
chr12124666818124667014E0815879
chr12124667018124667175E0816079
chr12124669042124669221E0818103
chr12124669337124669443E0818398
chr12124669709124669821E0818770
chr12124669851124669911E0818912
chr12124669942124670022E0819003
chr12124670434124670569E0819495
chr12124670584124671507E0819645
chr12124671548124671603E08110609
chr12124671941124672129E08111002
chr12124672185124672235E08111246
chr12124672258124672434E08111319
chr12124672539124673076E08111600
chr12124673091124673593E08112152
chr12124673608124673706E08112669
chr12124673765124673840E08112826
chr12124673964124674025E08113025
chr12124674048124674152E08113109
chr12124674181124674237E08113242
chr12124674298124674428E08113359
chr12124674753124674803E08113814
chr12124674885124675269E08113946
chr12124675305124675493E08114366
chr12124675525124675576E08114586
chr12124678925124680191E08117986
chr12124701993124702692E08141054
chr12124631690124631857E082-29082
chr12124641801124641858E082-19081
chr12124641869124642425E082-18514
chr12124652689124652918E082-8021
chr12124652922124653240E082-7699
chr12124658607124660053E082-886
chr12124660110124660160E082-779
chr12124660178124660918E082-21
chr12124661120124661170E082181
chr12124661224124661345E082285
chr12124661394124661444E082455
chr12124672258124672434E08211319
chr12124672539124673076E08211600
chr12124673091124673593E08212152
chr12124673608124673706E08212669
chr12124673765124673840E08212826
chr12124673964124674025E08213025
chr12124674048124674152E08213109
chr12124674181124674237E08213242
chr12124674298124674428E08213359
chr12124674753124674803E08213814
chr12124676843124676893E08215904
chr12124701855124701922E08240916
chr12124702877124702956E08241938