rs10858504

Homo sapiens
T>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0181 (5277/29118,TOPMED)
G=0203 (5758/28320,GnomAD)
G=0162 (812/5008,1000G)
G=0254 (979/3854,ALSPAC)
G=0249 (925/3708,TWINSUK)
chr12:77197636 (GRCh38.p7) (12q21.2)
AD
GWASdb2
1   publication(s)
See rs on genome
5 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 12NC_000012.12:g.77197636T>G
GRCh37.p13 chr 12NC_000012.11:g.77591416T>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.883G=0.117
1000GenomesAmericanSub694T=0.800G=0.200
1000GenomesEast AsianSub1008T=0.818G=0.182
1000GenomesEuropeSub1006T=0.764G=0.236
1000GenomesGlobalStudy-wide5008T=0.838G=0.162
1000GenomesSouth AsianSub978T=0.900G=0.100
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.746G=0.254
The Genome Aggregation DatabaseAfricanSub8516T=0.865G=0.135
The Genome Aggregation DatabaseAmericanSub660T=0.830G=0.170
The Genome Aggregation DatabaseEast AsianSub1552T=0.810G=0.190
The Genome Aggregation DatabaseEuropeSub17292T=0.759G=0.240
The Genome Aggregation DatabaseGlobalStudy-wide28320T=0.796G=0.203
The Genome Aggregation DatabaseOtherSub300T=0.840G=0.160
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.818G=0.181
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.751G=0.249
PMID Title Author Journal
22072270Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms.Wang KSJ Neural Transm (Vienna)

P-Value

SNP ID p-value Traits Study
rs108585046.04E-05alcohol withdrawal symptoms22072270

eQTL of rs10858504 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10858504 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr127755576977555985E070-35431
chr127755696177557035E070-34381
chr127762505277626392E07033636
chr127762505277626392E08133636
chr127762505277626392E08233636