rs10859259

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
C==0442 (13246/29926,GnomAD)
C==0462 (13467/29118,TOPMED)
C==0454 (2272/5008,1000G)
C==0372 (1432/3854,ALSPAC)
C==0370 (1373/3708,TWINSUK)
chr12:91976430 (GRCh38.p7) (12q21.33)
AD
GWASdb2
1   publication(s)
See rs on genome
64 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 12NC_000012.12:g.91976430C>T
GRCh37.p13 chr 12NC_000012.11:g.92370206C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.601T=0.399
1000GenomesAmericanSub694C=0.470T=0.530
1000GenomesEast AsianSub1008C=0.371T=0.629
1000GenomesEuropeSub1006C=0.387T=0.613
1000GenomesGlobalStudy-wide5008C=0.454T=0.546
1000GenomesSouth AsianSub978C=0.400T=0.600
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.372T=0.628
The Genome Aggregation DatabaseAfricanSub8706C=0.573T=0.427
The Genome Aggregation DatabaseAmericanSub836C=0.490T=0.510
The Genome Aggregation DatabaseEast AsianSub1616C=0.356T=0.644
The Genome Aggregation DatabaseEuropeSub18468C=0.388T=0.611
The Genome Aggregation DatabaseGlobalStudy-wide29926C=0.442T=0.557
The Genome Aggregation DatabaseOtherSub300C=0.320T=0.680
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.462T=0.537
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.370T=0.630
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs108592590.00053alcohol dependence20201924

eQTL of rs10859259 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10859259 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr129237908692379878E0678880
chr129237992792380182E0679721
chr129238034192380598E06710135
chr129241521492415491E06745008
chr129241549792415820E06745291
chr129237840992378679E0688203
chr129237992792380182E0689721
chr129238034192380598E06810135
chr129238185892382373E06811652
chr129238239492382520E06812188
chr129238254592382624E06812339
chr129238185892382373E06911652
chr129241487392415130E06944667
chr129241521492415491E06945008
chr129241549792415820E06945291
chr129237726192377311E0707055
chr129237735892377408E0707152
chr129237741092377494E0707204
chr129237779292377997E0707586
chr129237822292378408E0708016
chr129237840992378679E0708203
chr129237889292379063E0708686
chr129237908692379878E0708880
chr129237992792380182E0709721
chr129238034192380598E07010135
chr129238073892380790E07010532
chr129238096992381013E07010763
chr129238135792381684E07011151
chr129238185892382373E07011652
chr129238239492382520E07012188
chr129238632392386403E07016117
chr129238650392386662E07016297
chr129238681492386867E07016608
chr129238723692387286E07017030
chr129238746892387522E07017262
chr129238759792387694E07017391
chr129238770392387822E07017497
chr129238793492388056E07017728
chr129238810792388176E07017901
chr129238932392389447E07019117
chr129239728392397343E07027077
chr129239749692397540E07027290
chr129239762792397712E07027421
chr129239772092397824E07027514
chr129237889292379063E0718686
chr129237908692379878E0718880
chr129237992792380182E0719721
chr129238034192380598E07110135
chr129238073892380790E07110532
chr129238096992381013E07110763
chr129238135792381684E07111151
chr129238185892382373E07211652
chr129238239492382520E07212188
chr129238254592382624E07212339
chr129241521492415491E07245008
chr129241549792415820E07245291
chr129237908692379878E0748880
chr129237992792380182E0749721
chr129238185892382373E07411652
chr129238239492382520E07412188
chr129238770392387822E08117497
chr129238793492388056E08117728
chr129238810792388176E08117901
chr129238135792381684E08211151