rs10859354

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
T==0402 (12053/29936,GnomAD)
T==0464 (13519/29118,TOPMED)
T==0376 (1884/5008,1000G)
T==0363 (1398/3854,ALSPAC)
T==0374 (1386/3708,TWINSUK)
chr12:92655913 (GRCh38.p7) (12q22)
AD
GWASdb2
1   publication(s)
See rs on genome
6 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 12NC_000012.12:g.92655913T>C
GRCh37.p13 chr 12NC_000012.11:g.93049689T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.601C=0.399
1000GenomesAmericanSub694T=0.360C=0.640
1000GenomesEast AsianSub1008T=0.149C=0.851
1000GenomesEuropeSub1006T=0.384C=0.616
1000GenomesGlobalStudy-wide5008T=0.376C=0.624
1000GenomesSouth AsianSub978T=0.310C=0.690
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.363C=0.637
The Genome Aggregation DatabaseAfricanSub8702T=0.557C=0.443
The Genome Aggregation DatabaseAmericanSub836T=0.310C=0.690
The Genome Aggregation DatabaseEast AsianSub1620T=0.123C=0.877
The Genome Aggregation DatabaseEuropeSub18476T=0.358C=0.641
The Genome Aggregation DatabaseGlobalStudy-wide29936T=0.402C=0.597
The Genome Aggregation DatabaseOtherSub302T=0.380C=0.620
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.464C=0.535
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.374C=0.626
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs108593540.000664alcohol dependence20201924

eQTL of rs10859354 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10859354 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr129300216593002732E068-46957
chr129304311593044166E068-5523
chr129304311593044166E069-5523
chr129300216593002732E070-46957
chr129301368093013785E070-35904
chr129300947393009795E081-39894