rs10861184

Homo sapiens
A>G
TXNRD1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0078 (2360/29984,GnomAD)
G=0100 (2937/29118,TOPMED)
G=0081 (406/5008,1000G)
G=0048 (184/3854,ALSPAC)
G=0051 (189/3708,TWINSUK)
chr12:104270315 (GRCh38.p7) (12q23.3)
AD
GWASdb2
1   publication(s)
See rs on genome
8 Enhancers around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 12NC_000012.12:g.104270315A>G
GRCh37.p13 chr 12NC_000012.11:g.104664093A>G
TXNRD1 RefSeqGeneNG_029392.1:g.59535A>G

Gene: TXNRD1, thioredoxin reductase 1(plus strand)

Molecule type Change Amino acid[Codon] SO Term
TXNRD1 transcript variant 7NM_001093771.2:c.N/AIntron Variant
TXNRD1 transcript variant 5NM_001261445.1:c.N/AGenic Upstream Transcript Variant
TXNRD1 transcript variant 6NM_001261446.1:c.N/AGenic Upstream Transcript Variant
TXNRD1 transcript variant 4NM_003330.3:c.N/AGenic Upstream Transcript Variant
TXNRD1 transcript variant 1NM_182729.2:c.N/AGenic Upstream Transcript Variant
TXNRD1 transcript variant 2NM_182742.2:c.N/AGenic Upstream Transcript Variant
TXNRD1 transcript variant 3NM_182743.2:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.812G=0.188
1000GenomesAmericanSub694A=0.950G=0.050
1000GenomesEast AsianSub1008A=0.978G=0.022
1000GenomesEuropeSub1006A=0.955G=0.045
1000GenomesGlobalStudy-wide5008A=0.919G=0.081
1000GenomesSouth AsianSub978A=0.940G=0.060
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.952G=0.048
The Genome Aggregation DatabaseAfricanSub8726A=0.825G=0.175
The Genome Aggregation DatabaseAmericanSub838A=0.950G=0.050
The Genome Aggregation DatabaseEast AsianSub1622A=0.988G=0.012
The Genome Aggregation DatabaseEuropeSub18498A=0.959G=0.041
The Genome Aggregation DatabaseGlobalStudy-wide29984A=0.921G=0.078
The Genome Aggregation DatabaseOtherSub300A=0.950G=0.050
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.899G=0.100
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.949G=0.051
PMID Title Author Journal
19581569Genome-wide association study of alcohol dependence.Treutlein JArch Gen Psychiatry

P-Value

SNP ID p-value Traits Study
rs108611849.18E-05alcohol dependence19581569

eQTL of rs10861184 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10861184 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr12104683989104684040E06719896
chr12104679354104679580E06815261
chr12104698689104698798E06834596
chr12104698865104698986E06834772
chr12104670022104670561E0705929
chr12104683989104684040E07019896
chr12104686782104687054E07222689
chr12104670022104670561E0745929





Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr12104679607104681755E06715514
chr12104681823104681886E06717730
chr12104682008104683600E06717915
chr12104679607104681755E06815514
chr12104681823104681886E06817730
chr12104682008104683600E06817915
chr12104679607104681755E06915514
chr12104681823104681886E06917730
chr12104682008104683600E06917915
chr12104679607104681755E07015514
chr12104681823104681886E07017730
chr12104682008104683600E07017915
chr12104679607104681755E07115514
chr12104681823104681886E07117730
chr12104682008104683600E07117915
chr12104679607104681755E07215514
chr12104681823104681886E07217730
chr12104682008104683600E07217915
chr12104679607104681755E07315514
chr12104681823104681886E07317730
chr12104682008104683600E07317915
chr12104679607104681755E07415514
chr12104681823104681886E07417730
chr12104682008104683600E07417915
chr12104679607104681755E08115514
chr12104681823104681886E08117730
chr12104682008104683600E08117915
chr12104679607104681755E08215514
chr12104681823104681886E08217730
chr12104682008104683600E08217915