rs10868236

Organism: Homo sapiens

Alleles: G>T

Gene : Feature

NTRK2 : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G==0145 (4344/29958,GnomAD)
G==0120 (3516/29118,TOPMED)
G==0135 (674/5008,1000G)
G==0161 (621/3854,ALSPAC)
G==0179 (662/3708,TWINSUK)

Position: chr9:84893781 (GRCh38.p7) (9q21.33)

Phenotype: ND

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 388 Enhancers around

Promoter: 0 Promoter around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 9	NC_000009.12:g.84893781G>T
GRCh37.p13 chr 9	NC_000009.11:g.87508696G>T
NTRK2 RefSeqGene	NG_012201.2:g.230231G>T

Gene: NTRK2, neurotrophic receptor tyrosine kinase 2(plus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
NTRK2 transcript variant c	NM_001018064.2:c.	N/A	Intron Variant
NTRK2 transcript variant a	NM_006180.4:c.	N/A	Intron Variant
NTRK2 transcript variant b	NM_001007097.2:c.	N/A	Genic Downstream Transcript Variant
NTRK2 transcript variant d	NM_001018065.2:c.	N/A	Genic Downstream Transcript Variant
NTRK2 transcript variant e	NM_001018066.2:c.	N/A	Genic Downstream Transcript Variant
NTRK2 transcript variant f	NM_001291937.1:c.	N/A	Genic Downstream Transcript Variant
NTRK2 transcript variant X1	XM_005252001.2:c.	N/A	Intron Variant
NTRK2 transcript variant X2	XM_005252003.2:c.	N/A	Intron Variant
NTRK2 transcript variant X3	XM_005252004.2:c.	N/A	Intron Variant
NTRK2 transcript variant X5	XM_011518718.2:c.	N/A	Intron Variant
NTRK2 transcript variant X3	XM_017014751.1:c.	N/A	Intron Variant
NTRK2 transcript variant X6	XM_017014752.1:c.	N/A	Intron Variant
NTRK2 transcript variant X7	XM_017014753.1:c.	N/A	Intron Variant
NTRK2 transcript variant X8	XM_017014754.1:c.	N/A	Intron Variant
NTRK2 transcript variant X9	XM_005252006.3:c.	N/A	Genic Downstream Transcript Variant
NTRK2 transcript variant X14	XM_005252007.3:c.	N/A	Genic Downstream Transcript Variant
NTRK2 transcript variant X12	XM_011518720.2:c.	N/A	Genic Downstream Transcript Variant
NTRK2 transcript variant X10	XM_017014755.1:c.	N/A	Genic Downstream Transcript Variant
NTRK2 transcript variant X11	XM_017014756.1:c.	N/A	Genic Downstream Transcript Variant
NTRK2 transcript variant X13	XM_017014757.1:c.	N/A	Genic Downstream Transcript Variant
NTRK2 transcript variant X15	XM_017014758.1:c.	N/A	Genic Downstream Transcript Variant
NTRK2 transcript variant X16	XM_017014759.1:c.	N/A	Genic Downstream Transcript Variant
NTRK2 transcript variant X17	XM_017014760.1:c.	N/A	Genic Downstream Transcript Variant
NTRK2 transcript variant X18	XM_017014761.1:c.	N/A	Genic Downstream Transcript Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.078	T=0.922
1000Genomes	American	Sub	694	G=0.130	T=0.870
1000Genomes	East Asian	Sub	1008	G=0.250	T=0.750
1000Genomes	Europe	Sub	1006	G=0.160	T=0.840
1000Genomes	Global	Study-wide	5008	G=0.135	T=0.865
1000Genomes	South Asian	Sub	978	G=0.070	T=0.930
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.161	T=0.839
The Genome Aggregation Database	African	Sub	8730	G=0.074	T=0.926
The Genome Aggregation Database	American	Sub	836	G=0.130	T=0.870
The Genome Aggregation Database	East Asian	Sub	1612	G=0.287	T=0.713
The Genome Aggregation Database	Europe	Sub	18478	G=0.165	T=0.834
The Genome Aggregation Database	Global	Study-wide	29958	G=0.145	T=0.855
The Genome Aggregation Database	Other	Sub	302	G=0.210	T=0.790
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.120	T=0.879
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.179	T=0.821

PMID	Title	Author	Journal
19268276	Genome-wide association study of smoking initiation and current smoking.	Vink JM	Am J Hum Genet

P-Value

SNP ID	p-value	Traits	Study
rs10868236	9.64E-05	nicotine smoking	19268276

eQTL of rs10868236 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs10868236 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr9	87460905	87461003	E067	-47693
chr9	87461005	87461125	E067	-47571
chr9	87461179	87462266	E067	-46430
chr9	87462367	87462469	E067	-46227
chr9	87470198	87471949	E067	-36747
chr9	87472153	87472498	E067	-36198
chr9	87474816	87475773	E067	-32923
chr9	87476372	87476716	E067	-31980
chr9	87476826	87476968	E067	-31728
chr9	87476975	87477096	E067	-31600
chr9	87477120	87477197	E067	-31499
chr9	87477244	87477511	E067	-31185
chr9	87477568	87478212	E067	-30484
chr9	87480187	87480388	E067	-28308
chr9	87482150	87482216	E067	-26480
chr9	87488983	87489065	E067	-19631
chr9	87489076	87489133	E067	-19563
chr9	87489136	87489186	E067	-19510
chr9	87489365	87489415	E067	-19281
chr9	87489527	87489881	E067	-18815
chr9	87489970	87490754	E067	-17942
chr9	87508004	87508066	E067	-630
chr9	87508269	87508955	E067	0
chr9	87509077	87509551	E067	381
chr9	87509786	87509862	E067	1090
chr9	87509943	87510048	E067	1247
chr9	87512450	87512501	E067	3754
chr9	87512573	87512623	E067	3877
chr9	87512670	87512955	E067	3974
chr9	87513104	87513181	E067	4408
chr9	87513228	87513323	E067	4532
chr9	87514803	87514855	E067	6107
chr9	87515119	87515159	E067	6423
chr9	87521702	87521810	E067	13006
chr9	87523143	87523197	E067	14447
chr9	87531458	87531628	E067	22762
chr9	87531749	87531999	E067	23053
chr9	87532240	87532320	E067	23544
chr9	87532352	87532488	E067	23656
chr9	87537078	87537280	E067	28382
chr9	87537535	87537585	E067	28839
chr9	87537674	87537754	E067	28978
chr9	87547828	87548395	E067	39132
chr9	87551689	87552489	E067	42993
chr9	87552514	87552626	E067	43818
chr9	87552670	87552764	E067	43974
chr9	87461179	87462266	E068	-46430
chr9	87472153	87472498	E068	-36198
chr9	87472647	87473019	E068	-35677
chr9	87473088	87473948	E068	-34748
chr9	87474816	87475773	E068	-32923
chr9	87476070	87476120	E068	-32576
chr9	87476201	87476286	E068	-32410
chr9	87476372	87476716	E068	-31980
chr9	87476826	87476968	E068	-31728
chr9	87476975	87477096	E068	-31600
chr9	87477120	87477197	E068	-31499
chr9	87477244	87477511	E068	-31185
chr9	87477568	87478212	E068	-30484
chr9	87480187	87480388	E068	-28308
chr9	87480493	87480543	E068	-28153
chr9	87480592	87480726	E068	-27970
chr9	87489970	87490754	E068	-17942
chr9	87509077	87509551	E068	381
chr9	87509786	87509862	E068	1090
chr9	87512450	87512501	E068	3754
chr9	87512573	87512623	E068	3877
chr9	87512670	87512955	E068	3974
chr9	87513104	87513181	E068	4408
chr9	87513228	87513323	E068	4532
chr9	87521702	87521810	E068	13006
chr9	87532240	87532320	E068	23544
chr9	87532352	87532488	E068	23656
chr9	87532502	87533196	E068	23806
chr9	87533314	87533364	E068	24618
chr9	87537078	87537280	E068	28382
chr9	87537535	87537585	E068	28839
chr9	87537674	87537754	E068	28978
chr9	87545185	87545235	E068	36489
chr9	87547828	87548395	E068	39132
chr9	87551316	87551360	E068	42620
chr9	87551689	87552489	E068	42993
chr9	87552514	87552626	E068	43818
chr9	87459090	87459144	E069	-49552
chr9	87460905	87461003	E069	-47693
chr9	87461005	87461125	E069	-47571
chr9	87461179	87462266	E069	-46430
chr9	87462367	87462469	E069	-46227
chr9	87465657	87465726	E069	-42970
chr9	87465899	87466008	E069	-42688
chr9	87466013	87466120	E069	-42576
chr9	87466493	87466677	E069	-42019
chr9	87466693	87467489	E069	-41207
chr9	87467596	87467879	E069	-40817
chr9	87467897	87468352	E069	-40344
chr9	87470198	87471949	E069	-36747
chr9	87472153	87472498	E069	-36198
chr9	87472647	87473019	E069	-35677
chr9	87476372	87476716	E069	-31980
chr9	87476826	87476968	E069	-31728
chr9	87476975	87477096	E069	-31600
chr9	87477120	87477197	E069	-31499
chr9	87477244	87477511	E069	-31185
chr9	87480493	87480543	E069	-28153
chr9	87480592	87480726	E069	-27970
chr9	87482150	87482216	E069	-26480
chr9	87488820	87488870	E069	-19826
chr9	87488901	87488951	E069	-19745
chr9	87488983	87489065	E069	-19631
chr9	87489076	87489133	E069	-19563
chr9	87489136	87489186	E069	-19510
chr9	87489365	87489415	E069	-19281
chr9	87489527	87489881	E069	-18815
chr9	87489970	87490754	E069	-17942
chr9	87508004	87508066	E069	-630
chr9	87508269	87508955	E069	0
chr9	87509077	87509551	E069	381
chr9	87509786	87509862	E069	1090
chr9	87509943	87510048	E069	1247
chr9	87510161	87510240	E069	1465
chr9	87510307	87510432	E069	1611
chr9	87512450	87512501	E069	3754
chr9	87512573	87512623	E069	3877
chr9	87512670	87512955	E069	3974
chr9	87513104	87513181	E069	4408
chr9	87513228	87513323	E069	4532
chr9	87531749	87531999	E069	23053
chr9	87532240	87532320	E069	23544
chr9	87532352	87532488	E069	23656
chr9	87532502	87533196	E069	23806
chr9	87533314	87533364	E069	24618
chr9	87537078	87537280	E069	28382
chr9	87537535	87537585	E069	28839
chr9	87537674	87537754	E069	28978
chr9	87538235	87538285	E069	29539
chr9	87548532	87548623	E069	39836
chr9	87551689	87552489	E069	42993
chr9	87552514	87552626	E069	43818
chr9	87552670	87552764	E069	43974
chr9	87459090	87459144	E070	-49552
chr9	87460905	87461003	E070	-47693
chr9	87461005	87461125	E070	-47571
chr9	87461179	87462266	E070	-46430
chr9	87462367	87462469	E070	-46227
chr9	87462853	87462903	E070	-45793
chr9	87462997	87463095	E070	-45601
chr9	87463347	87463449	E070	-45247
chr9	87464868	87464918	E070	-43778
chr9	87480187	87480388	E070	-28308
chr9	87480493	87480543	E070	-28153
chr9	87480592	87480726	E070	-27970
chr9	87509943	87510048	E070	1247
chr9	87510161	87510240	E070	1465
chr9	87510307	87510432	E070	1611
chr9	87512450	87512501	E070	3754
chr9	87512573	87512623	E070	3877
chr9	87512670	87512955	E070	3974
chr9	87513104	87513181	E070	4408
chr9	87513228	87513323	E070	4532
chr9	87531458	87531628	E070	22762
chr9	87531749	87531999	E070	23053
chr9	87532240	87532320	E070	23544
chr9	87532352	87532488	E070	23656
chr9	87532502	87533196	E070	23806
chr9	87539211	87539700	E070	30515
chr9	87539741	87539941	E070	31045
chr9	87540187	87540284	E070	31491
chr9	87551689	87552489	E070	42993
chr9	87552514	87552626	E070	43818
chr9	87552670	87552764	E070	43974
chr9	87460905	87461003	E071	-47693
chr9	87461005	87461125	E071	-47571
chr9	87461179	87462266	E071	-46430
chr9	87462367	87462469	E071	-46227
chr9	87465657	87465726	E071	-42970
chr9	87465899	87466008	E071	-42688
chr9	87466013	87466120	E071	-42576
chr9	87470198	87471949	E071	-36747
chr9	87474741	87474810	E071	-33886
chr9	87474816	87475773	E071	-32923
chr9	87476201	87476286	E071	-32410
chr9	87476372	87476716	E071	-31980
chr9	87476826	87476968	E071	-31728
chr9	87476975	87477096	E071	-31600
chr9	87477120	87477197	E071	-31499
chr9	87489365	87489415	E071	-19281
chr9	87489527	87489881	E071	-18815
chr9	87489970	87490754	E071	-17942
chr9	87508269	87508955	E071	0
chr9	87509077	87509551	E071	381
chr9	87509786	87509862	E071	1090
chr9	87509943	87510048	E071	1247
chr9	87510161	87510240	E071	1465
chr9	87510307	87510432	E071	1611
chr9	87512450	87512501	E071	3754
chr9	87512573	87512623	E071	3877
chr9	87512670	87512955	E071	3974
chr9	87513104	87513181	E071	4408
chr9	87532240	87532320	E071	23544
chr9	87532352	87532488	E071	23656
chr9	87532502	87533196	E071	23806
chr9	87533314	87533364	E071	24618
chr9	87537078	87537280	E071	28382
chr9	87537535	87537585	E071	28839
chr9	87537674	87537754	E071	28978
chr9	87551316	87551360	E071	42620
chr9	87551689	87552489	E071	42993
chr9	87552514	87552626	E071	43818
chr9	87552670	87552764	E071	43974
chr9	87461179	87462266	E072	-46430
chr9	87462367	87462469	E072	-46227
chr9	87472647	87473019	E072	-35677
chr9	87474816	87475773	E072	-32923
chr9	87476201	87476286	E072	-32410
chr9	87476372	87476716	E072	-31980
chr9	87476826	87476968	E072	-31728
chr9	87476975	87477096	E072	-31600
chr9	87477120	87477197	E072	-31499
chr9	87477244	87477511	E072	-31185
chr9	87477568	87478212	E072	-30484
chr9	87482150	87482216	E072	-26480
chr9	87488983	87489065	E072	-19631
chr9	87489076	87489133	E072	-19563
chr9	87489136	87489186	E072	-19510
chr9	87489365	87489415	E072	-19281
chr9	87489527	87489881	E072	-18815
chr9	87489970	87490754	E072	-17942
chr9	87508269	87508955	E072	0
chr9	87509077	87509551	E072	381
chr9	87509786	87509862	E072	1090
chr9	87509943	87510048	E072	1247
chr9	87510161	87510240	E072	1465
chr9	87510307	87510432	E072	1611
chr9	87512450	87512501	E072	3754
chr9	87512573	87512623	E072	3877
chr9	87512670	87512955	E072	3974
chr9	87513104	87513181	E072	4408
chr9	87513228	87513323	E072	4532
chr9	87513706	87513773	E072	5010
chr9	87532502	87533196	E072	23806
chr9	87533314	87533364	E072	24618
chr9	87537078	87537280	E072	28382
chr9	87537535	87537585	E072	28839
chr9	87547828	87548395	E072	39132
chr9	87551689	87552489	E072	42993
chr9	87552514	87552626	E072	43818
chr9	87552670	87552764	E072	43974
chr9	87461179	87462266	E073	-46430
chr9	87465657	87465726	E073	-42970
chr9	87465899	87466008	E073	-42688
chr9	87466693	87467489	E073	-41207
chr9	87467596	87467879	E073	-40817
chr9	87467897	87468352	E073	-40344
chr9	87468401	87468456	E073	-40240
chr9	87468547	87468683	E073	-40013
chr9	87469909	87470020	E073	-38676
chr9	87470198	87471949	E073	-36747
chr9	87472647	87473019	E073	-35677
chr9	87473088	87473948	E073	-34748
chr9	87474741	87474810	E073	-33886
chr9	87474816	87475773	E073	-32923
chr9	87476201	87476286	E073	-32410
chr9	87476372	87476716	E073	-31980
chr9	87476826	87476968	E073	-31728
chr9	87476975	87477096	E073	-31600
chr9	87477120	87477197	E073	-31499
chr9	87477244	87477511	E073	-31185
chr9	87477568	87478212	E073	-30484
chr9	87478393	87478564	E073	-30132
chr9	87478610	87478662	E073	-30034
chr9	87478907	87479077	E073	-29619
chr9	87480187	87480388	E073	-28308
chr9	87480493	87480543	E073	-28153
chr9	87480592	87480726	E073	-27970
chr9	87489365	87489415	E073	-19281
chr9	87489527	87489881	E073	-18815
chr9	87489970	87490754	E073	-17942
chr9	87493940	87493990	E073	-14706
chr9	87502264	87502361	E073	-6335
chr9	87502386	87502477	E073	-6219
chr9	87502535	87502608	E073	-6088
chr9	87509077	87509551	E073	381
chr9	87509786	87509862	E073	1090
chr9	87509943	87510048	E073	1247
chr9	87510161	87510240	E073	1465
chr9	87510307	87510432	E073	1611
chr9	87512450	87512501	E073	3754
chr9	87512573	87512623	E073	3877
chr9	87512670	87512955	E073	3974
chr9	87513104	87513181	E073	4408
chr9	87531458	87531628	E073	22762
chr9	87531749	87531999	E073	23053
chr9	87532240	87532320	E073	23544
chr9	87532352	87532488	E073	23656
chr9	87532502	87533196	E073	23806
chr9	87533314	87533364	E073	24618
chr9	87533432	87533660	E073	24736
chr9	87537078	87537280	E073	28382
chr9	87537535	87537585	E073	28839
chr9	87537674	87537754	E073	28978
chr9	87547530	87547570	E073	38834
chr9	87547664	87547704	E073	38968
chr9	87547828	87548395	E073	39132
chr9	87551689	87552489	E073	42993
chr9	87552514	87552626	E073	43818
chr9	87552670	87552764	E073	43974
chr9	87552848	87552919	E073	44152
chr9	87552959	87553096	E073	44263
chr9	87461179	87462266	E074	-46430
chr9	87462367	87462469	E074	-46227
chr9	87466493	87466677	E074	-42019
chr9	87466693	87467489	E074	-41207
chr9	87470198	87471949	E074	-36747
chr9	87489970	87490754	E074	-17942
chr9	87508269	87508955	E074	0
chr9	87509077	87509551	E074	381
chr9	87509786	87509862	E074	1090
chr9	87509943	87510048	E074	1247
chr9	87510161	87510240	E074	1465
chr9	87510307	87510432	E074	1611
chr9	87512450	87512501	E074	3754
chr9	87512573	87512623	E074	3877
chr9	87512670	87512955	E074	3974
chr9	87513104	87513181	E074	4408
chr9	87513228	87513323	E074	4532
chr9	87532502	87533196	E074	23806
chr9	87533314	87533364	E074	24618
chr9	87537078	87537280	E074	28382
chr9	87537535	87537585	E074	28839
chr9	87537674	87537754	E074	28978
chr9	87547828	87548395	E074	39132
chr9	87548532	87548623	E074	39836
chr9	87551689	87552489	E074	42993
chr9	87552514	87552626	E074	43818
chr9	87552670	87552764	E074	43974
chr9	87552848	87552919	E074	44152
chr9	87552959	87553096	E074	44263
chr9	87476826	87476968	E081	-31728
chr9	87476975	87477096	E081	-31600
chr9	87477120	87477197	E081	-31499
chr9	87477244	87477511	E081	-31185
chr9	87495057	87495251	E081	-13445
chr9	87495276	87495348	E081	-13348
chr9	87512573	87512623	E081	3877
chr9	87512670	87512955	E081	3974
chr9	87532240	87532320	E081	23544
chr9	87532352	87532488	E081	23656
chr9	87532502	87533196	E081	23806
chr9	87533314	87533364	E081	24618
chr9	87533432	87533660	E081	24736
chr9	87538875	87538942	E081	30179
chr9	87539041	87539091	E081	30345
chr9	87539211	87539700	E081	30515
chr9	87539741	87539941	E081	31045
chr9	87540187	87540284	E081	31491
chr9	87551689	87552489	E081	42993
chr9	87552514	87552626	E081	43818
chr9	87552670	87552764	E081	43974
chr9	87552848	87552919	E081	44152
chr9	87552959	87553096	E081	44263
chr9	87556606	87556656	E081	47910
chr9	87556811	87556878	E081	48115
chr9	87556918	87556979	E081	48222
chr9	87557035	87557085	E081	48339
chr9	87557181	87557344	E081	48485
chr9	87459090	87459144	E082	-49552
chr9	87512450	87512501	E082	3754
chr9	87512573	87512623	E082	3877
chr9	87512670	87512955	E082	3974
chr9	87513104	87513181	E082	4408
chr9	87531458	87531628	E082	22762
chr9	87531749	87531999	E082	23053
chr9	87532240	87532320	E082	23544
chr9	87532352	87532488	E082	23656
chr9	87532502	87533196	E082	23806
chr9	87533314	87533364	E082	24618
chr9	87539211	87539700	E082	30515
chr9	87539741	87539941	E082	31045
chr9	87540187	87540284	E082	31491
chr9	87551689	87552489	E082	42993
chr9	87552514	87552626	E082	43818
chr9	87552670	87552764	E082	43974
chr9	87552848	87552919	E082	44152
chr9	87552959	87553096	E082	44263
chr9	87556811	87556878	E082	48115
chr9	87556918	87556979	E082	48222
chr9	87557035	87557085	E082	48339
chr9	87557181	87557344	E082	48485