rs10871341

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
A==0490 (14692/29948,GnomAD)
G=0410 (11941/29118,TOPMED)
G=0451 (2261/5008,1000G)
A==0333 (1284/3854,ALSPAC)
A==0344 (1274/3708,TWINSUK)
chr16:77709280 (GRCh38.p7) (16q23.1)
AD
GWASdb2
1   publication(s)
See rs on genome
33 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 16NC_000016.10:g.77709280A>G
GRCh37.p13 chr 16NC_000016.9:g.77743177A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.947G=0.053
1000GenomesAmericanSub694A=0.390G=0.610
1000GenomesEast AsianSub1008A=0.411G=0.589
1000GenomesEuropeSub1006A=0.364G=0.636
1000GenomesGlobalStudy-wide5008A=0.549G=0.451
1000GenomesSouth AsianSub978A=0.450G=0.550
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.333G=0.667
The Genome Aggregation DatabaseAfricanSub8718A=0.861G=0.139
The Genome Aggregation DatabaseAmericanSub838A=0.330G=0.670
The Genome Aggregation DatabaseEast AsianSub1618A=0.421G=0.579
The Genome Aggregation DatabaseEuropeSub18474A=0.330G=0.669
The Genome Aggregation DatabaseGlobalStudy-wide29948A=0.490G=0.509
The Genome Aggregation DatabaseOtherSub300A=0.410G=0.590
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.589G=0.410
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.344G=0.656
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs108713410.000817alcohol dependence24277619

eQTL of rs10871341 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr16:77743177RP11-264M12.2ENSG00000261707.1A>G1.9582e-5-33720Caudate_basal_ganglia

meQTL of rs10871341 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr167770964577710060E067-33117
chr167776628277766453E06723105
chr167776646977766583E06723292
chr167776659877766783E06723421
chr167769404977694100E068-49077
chr167770964577710060E068-33117
chr167773007677730433E068-12744
chr167771741777717765E070-25412
chr167771868777718765E070-24412
chr167771887377719147E070-24030
chr167769404977694100E072-49077
chr167770964577710060E072-33117
chr167769404977694100E073-49077
chr167769404977694100E081-49077
chr167769414077694601E081-48576
chr167771735877717414E081-25763
chr167771741777717765E081-25412
chr167771868777718765E081-24412
chr167771887377719147E081-24030
chr167772036577720415E081-22762
chr167772052477720590E081-22587
chr167772158677721865E081-21312
chr167772188177721975E081-21202
chr167772254577722595E081-20582
chr167772339577723478E081-19699
chr167772365177723943E081-19234
chr167772416577724215E081-18962
chr167773007677730433E081-12744
chr167771726177717346E082-25831
chr167771735877717414E082-25763
chr167771741777717765E082-25412
chr167771868777718765E082-24412
chr167771887377719147E082-24030







Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr167775580677757470E06712629
chr167775580677757470E06812629
chr167775580677757470E06912629
chr167775580677757470E07012629
chr167775580677757470E07112629
chr167775580677757470E07212629
chr167775580677757470E07312629
chr167775580677757470E07412629
chr167775580677757470E08112629
chr167775580677757470E08212629