SNP Detail Info-rs10873350

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G==0221 (6623/29908,GnomAD)
G==0215 (6263/29118,TOPMED)
G==0155 (776/5008,1000G)
G==0298 (1150/3854,ALSPAC)
G==0323 (1198/3708,TWINSUK)

Position: chr14:83714525 (GRCh38.p7) (14q31.2)

Phenotype: AD

Dataset:

GWASdb2

Publications: 2 publication(s)

Genomic View: See rs on genome

Enhancer: 10 Enhancers around

Promoter: 0 Promoter around

Sequence Name	Change(s)
GRCh38.p7 chr 14	NC_000014.9:g.83714525G>A
GRCh37.p13 chr 14	NC_000014.8:g.84180869G>A

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.118	A=0.882
1000Genomes	American	Sub	694	G=0.200	A=0.800
1000Genomes	East Asian	Sub	1008	G=0.033	A=0.967
1000Genomes	Europe	Sub	1006	G=0.300	A=0.700
1000Genomes	Global	Study-wide	5008	G=0.155	A=0.845
1000Genomes	South Asian	Sub	978	G=0.150	A=0.850
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.298	A=0.702
The Genome Aggregation Database	African	Sub	8726	G=0.145	A=0.855
The Genome Aggregation Database	American	Sub	834	G=0.160	A=0.840
The Genome Aggregation Database	East Asian	Sub	1592	G=0.035	A=0.965
The Genome Aggregation Database	Europe	Sub	18456	G=0.276	A=0.723
The Genome Aggregation Database	Global	Study-wide	29908	G=0.221	A=0.778
The Genome Aggregation Database	Other	Sub	300	G=0.200	A=0.800
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.215	A=0.784
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.323	A=0.677

PMID	Title	Author	Journal
20201924	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	Edenberg HJ	Alcohol Clin Exp Res
21302341	Replicated genome wide association for dependence on illegal substances: genomic regions identified by overlapping clusters of nominally positive SNPs.	Drgon T	Am J Med Genet B Neuropsychiatr Genet

SNP ID	p-value	Traits	Study
rs10873350	0.000819	alcohol dependence	20201924

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr14	84172591	84173554	E081	-7315
chr14	84176397	84176487	E081	-4382
chr14	84177169	84177239	E081	-3630
chr14	84177393	84178470	E081	-2399
chr14	84180768	84180904	E081	0
chr14	84212639	84213018	E081	31770
chr14	84213210	84213277	E081	32341
chr14	84213386	84213449	E081	32517
chr14	84213561	84213747	E081	32692
chr14	84177393	84178470	E082	-2399

rs10873350