rs10874182

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0193 (5792/29928,GnomAD)
T=0219 (6397/29118,TOPMED)
T=0247 (1237/5008,1000G)
T=0116 (448/3854,ALSPAC)
T=0118 (437/3708,TWINSUK)
chr1:80935413 (GRCh38.p7) (1p31.1)
AD
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 1NC_000001.11:g.80935413C>T
GRCh37.p13 chr 1NC_000001.10:g.81401098C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.612T=0.388
1000GenomesAmericanSub694C=0.900T=0.100
1000GenomesEast AsianSub1008C=0.850T=0.150
1000GenomesEuropeSub1006C=0.864T=0.136
1000GenomesGlobalStudy-wide5008C=0.753T=0.247
1000GenomesSouth AsianSub978C=0.630T=0.370
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.884T=0.116
The Genome Aggregation DatabaseAfricanSub8696C=0.659T=0.341
The Genome Aggregation DatabaseAmericanSub836C=0.890T=0.110
The Genome Aggregation DatabaseEast AsianSub1616C=0.791T=0.209
The Genome Aggregation DatabaseEuropeSub18478C=0.873T=0.126
The Genome Aggregation DatabaseGlobalStudy-wide29928C=0.806T=0.193
The Genome Aggregation DatabaseOtherSub302C=0.800T=0.200
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.780T=0.219
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.882T=0.118
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs108741820.000492alcohol dependence24277619

eQTL of rs10874182 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10874182 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr18135806081358134E081-42964
chr18135818781359212E081-41886
chr18136054981360949E081-40149