rs10881838

Homo sapiens
A>G
HTR7 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0385 (11523/29910,GnomAD)
G=0412 (12015/29118,TOPMED)
G=0430 (2155/5008,1000G)
G=0283 (1089/3854,ALSPAC)
G=0281 (1043/3708,TWINSUK)
chr10:90830476 (GRCh38.p7) (10q23.31)
AD
GWASdb2
1   publication(s)
See rs on genome
18 Enhancers around
21 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.90830476A>G
GRCh37.p13 chr 10NC_000010.10:g.92590233A>G
HTR7 RefSeqGeneNG_029218.1:g.32439T>C

Gene: HTR7, 5-hydroxytryptamine receptor 7(minus strand)

Molecule type Change Amino acid[Codon] SO Term
HTR7 transcript variant aNM_000872.4:c.N/AIntron Variant
HTR7 transcript variant dNM_019859.3:c.N/AIntron Variant
HTR7 transcript variant bNM_019860.3:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.398G=0.602
1000GenomesAmericanSub694A=0.620G=0.380
1000GenomesEast AsianSub1008A=0.577G=0.423
1000GenomesEuropeSub1006A=0.694G=0.306
1000GenomesGlobalStudy-wide5008A=0.570G=0.430
1000GenomesSouth AsianSub978A=0.630G=0.370
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.717G=0.283
The Genome Aggregation DatabaseAfricanSub8700A=0.431G=0.569
The Genome Aggregation DatabaseAmericanSub836A=0.630G=0.370
The Genome Aggregation DatabaseEast AsianSub1620A=0.552G=0.448
The Genome Aggregation DatabaseEuropeSub18452A=0.704G=0.296
The Genome Aggregation DatabaseGlobalStudy-wide29910A=0.614G=0.385
The Genome Aggregation DatabaseOtherSub302A=0.740G=0.260
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.587G=0.412
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.719G=0.281
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs108818380.00063alcohol consumption (maxi-drinks)24277619

eQTL of rs10881838 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10881838 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr109263305792633097E06742824
chr109263338892633438E06743155
chr109263358692633643E06743353
chr109263401892634073E06743785
chr109263305792633097E06942824
chr109263338892633438E06943155
chr109263358692633643E06943353
chr109263305792633097E07042824
chr109263358692633643E07043353
chr109263305792633097E07342824
chr109263338892633438E07343155
chr109263358692633643E07343353
chr109263305792633097E08142824
chr109263338892633438E08143155
chr109263358692633643E08143353
chr109263338892633438E08243155
chr109263358692633643E08243353
chr109263401892634073E08243785






Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr109261595792618611E06725724
chr109263077892632583E06740545
chr109261595792618611E06825724
chr109263077892632583E06840545
chr109261595792618611E06925724
chr109263077892632583E06940545
chr109263077892632583E07040545
chr109261595792618611E07125724
chr109263077892632583E07140545
chr109261595792618611E07225724
chr109263077892632583E07240545
chr109261595792618611E07325724
chr109263077892632583E07340545
chr109261595792618611E07425724
chr109263077892632583E07440545
chr109263077892632583E08140545
chr109261475592614846E08224522
chr109261555192615609E08225318
chr109261574592615805E08225512
chr109261595792618611E08225724
chr109263077892632583E08240545