rs10902222

Homo sapiens
G>T
RPLP2 : Intron Variant
PIDD1 : 2KB Upstream Variant
SNORA52 : 2KB Upstream Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0319 (9296/29118,TOPMED)
G==0315 (8550/27122,GnomAD)
G==0367 (1839/5008,1000G)
G==0317 (1220/3854,ALSPAC)
G==0316 (1170/3708,TWINSUK)
chr11:810882 (GRCh38.p7) (11p15.5)
AD
GWASdb2
2   publication(s)
See rs on genome
311 Enhancers around
58 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.810882G>T
GRCh37.p13 chr 11NC_000011.9:g.810882G>T

Gene: RPLP2, ribosomal protein lateral stalk subunit P2(plus strand)

Molecule type Change Amino acid[Codon] SO Term
RPLP2 transcriptNM_001004.3:c.N/AIntron Variant

Gene: PIDD1, p53-induced death domain protein 1(minus strand): 2KB Upstream Variant

Molecule type Change Amino acid[Codon] SO Term
PIDD1 transcript variant 1NM_145886.3:c.N/AN/A
PIDD1 transcript variant 3NM_145887.3:c.N/AN/A
PIDD1 transcript variant X1XM_005253005.4:c.N/AUpstream Transcript Variant
PIDD1 transcript variant X2XM_005253006.4:c.N/AUpstream Transcript Variant
PIDD1 transcript variant X3XM_005253007.3:c.N/AUpstream Transcript Variant
PIDD1 transcript variant X7XM_005253008.4:c.N/AUpstream Transcript Variant
PIDD1 transcript variant X4XM_011520209.2:c.N/AUpstream Transcript Variant
PIDD1 transcript variant X5XM_011520210.2:c.N/AUpstream Transcript Variant
PIDD1 transcript variant X6XM_011520211.2:c.N/AUpstream Transcript Variant
PIDD1 transcript variant X8XM_011520212.1:c.N/AUpstream Transcript Variant
PIDD1 transcript variant X11XM_011520213.2:c.N/AN/A
PIDD1 transcript variant X12XM_017017993.1:c.N/AN/A
PIDD1 transcript variant X13XR_001747922.1:n.N/AUpstream Transcript Variant
PIDD1 transcript variant X10XR_001747921.1:n.N/AN/A
PIDD1 transcript variant X9XR_930877.1:n.N/AN/A

Gene: SNORA52, small nucleolar RNA, H/ACA box 52(plus strand): 2KB Upstream Variant

Molecule type Change Amino acid[Codon] SO Term
SNORA52 transcriptNR_002585.1:n.N/AUpstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.297T=0.703
1000GenomesAmericanSub694G=0.250T=0.750
1000GenomesEast AsianSub1008G=0.402T=0.598
1000GenomesEuropeSub1006G=0.356T=0.644
1000GenomesGlobalStudy-wide5008G=0.367T=0.633
1000GenomesSouth AsianSub978G=0.520T=0.480
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.317T=0.683
The Genome Aggregation DatabaseAfricanSub8184G=0.303T=0.697
The Genome Aggregation DatabaseAmericanSub758G=0.300T=0.700
The Genome Aggregation DatabaseEast AsianSub1578G=0.399T=0.601
The Genome Aggregation DatabaseEuropeSub16312G=0.311T=0.688
The Genome Aggregation DatabaseGlobalStudy-wide27122G=0.315T=0.684
The Genome Aggregation DatabaseOtherSub290G=0.490T=0.510
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.319T=0.680
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.316T=0.684
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res
25010687Cis and trans effects of human genomic variants on gene expression.Bryois JPLoS Genet

P-Value

SNP ID p-value Traits Study
rs109022220.00096alcohol dependence20201924

eQTL of rs10902222 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10902222 in Fetal Brain

Probe ID Position Gene beta p-value
cg17628894chr11:804452LRDD0.03353739486937472.2044e-13
cg17628894chr11:804452LRDD0.0335373952.2000e-13
cg17628894chr11:804452LRDD0.0335373952.2000e-13

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr11761685761879E067-49003
chr11761975762015E067-48867
chr11762139762189E067-48693
chr11762288763622E067-47260
chr11771415771535E067-39347
chr11771654771708E067-39174
chr11771767771897E067-38985
chr11771964772195E067-38687
chr11772467772517E067-38365
chr11772966773229E067-37653
chr11773359773423E067-37459
chr11773474773524E067-37358
chr11773660773790E067-37092
chr11773804774001E067-36881
chr11774037774168E067-36714
chr11783370784241E067-26641
chr11811429812418E067547
chr11859553860304E06748671
chr11762288763622E068-47260
chr11771654771708E068-39174
chr11771767771897E068-38985
chr11771964772195E068-38687
chr11772467772517E068-38365
chr11772664772728E068-38154
chr11772833772924E068-37958
chr11773804774001E068-36881
chr11774037774168E068-36714
chr11775008775954E068-34928
chr11782822783126E068-27756
chr11783166783235E068-27647
chr11783370784241E068-26641
chr11794043794710E068-16172
chr11854858854989E06843976
chr11855099855430E06844217
chr11761685761879E069-49003
chr11761975762015E069-48867
chr11762139762189E069-48693
chr11762288763622E069-47260
chr11763800764270E069-46612
chr11764277764571E069-46311
chr11764687764950E069-45932
chr11764999765081E069-45801
chr11765118765640E069-45242
chr11771654771708E069-39174
chr11771767771897E069-38985
chr11771964772195E069-38687
chr11772467772517E069-38365
chr11772664772728E069-38154
chr11772833772924E069-37958
chr11772966773229E069-37653
chr11773359773423E069-37459
chr11773474773524E069-37358
chr11773660773790E069-37092
chr11773804774001E069-36881
chr11774037774168E069-36714
chr11774412774546E069-36336
chr11775008775954E069-34928
chr11778786778866E069-32016
chr11782822783126E069-27756
chr11783166783235E069-27647
chr11783370784241E069-26641
chr11811429812418E069547
chr11851279851799E06940397
chr11772467772517E070-38365
chr11772664772728E070-38154
chr11772833772924E070-37958
chr11772966773229E070-37653
chr11773359773423E070-37459
chr11773474773524E070-37358
chr11773660773790E070-37092
chr11773804774001E070-36881
chr11774037774168E070-36714
chr11774412774546E070-36336
chr11775008775954E070-34928
chr11778786778866E070-32016
chr11778878778990E070-31892
chr11779041779261E070-31621
chr11783370784241E070-26641
chr11793350794013E070-16869
chr11794043794710E070-16172
chr11802799803038E070-7844
chr11803170803233E070-7649
chr11803237803529E070-7353
chr11803550803788E070-7094
chr11823374823481E07012492
chr11823493823647E07012611
chr11823923824235E07013041
chr11851279851799E07040397
chr11854356854477E07043474
chr11854632854741E07043750
chr11854858854989E07043976
chr11856232856419E07045350
chr11856538856880E07045656
chr11858325859057E07047443
chr11762288763622E071-47260
chr11763688763754E071-47128
chr11763800764270E071-46612
chr11764277764571E071-46311
chr11764687764950E071-45932
chr11764999765081E071-45801
chr11765118765640E071-45242
chr11770525770608E071-40274
chr11770624770725E071-40157
chr11771050771259E071-39623
chr11771415771535E071-39347
chr11771654771708E071-39174
chr11771767771897E071-38985
chr11771964772195E071-38687
chr11772467772517E071-38365
chr11773660773790E071-37092
chr11773804774001E071-36881
chr11774037774168E071-36714
chr11775008775954E071-34928
chr11783370784241E071-26641
chr11794043794710E071-16172
chr11811429812418E071547
chr11812431812503E0711549
chr11812514812747E0711632
chr11822657822747E07111775
chr11851279851799E07140397
chr11854021854297E07143139
chr11854356854477E07143474
chr11854632854741E07143750
chr11854858854989E07143976
chr11855099855430E07144217
chr11855505855641E07144623
chr11857935858289E07147053
chr11859403859479E07148521
chr11860410860523E07149528
chr11761685761879E072-49003
chr11761975762015E072-48867
chr11762139762189E072-48693
chr11762288763622E072-47260
chr11765118765640E072-45242
chr11771654771708E072-39174
chr11771767771897E072-38985
chr11771964772195E072-38687
chr11772467772517E072-38365
chr11773474773524E072-37358
chr11773660773790E072-37092
chr11775008775954E072-34928
chr11782822783126E072-27756
chr11783166783235E072-27647
chr11783370784241E072-26641
chr11793350794013E072-16869
chr11839900841657E07229018
chr11854858854989E07243976
chr11855099855430E07244217
chr11855505855641E07244623
chr11855785856113E07244903
chr11761975762015E073-48867
chr11762139762189E073-48693
chr11762288763622E073-47260
chr11771654771708E073-39174
chr11771767771897E073-38985
chr11771964772195E073-38687
chr11772467772517E073-38365
chr11772664772728E073-38154
chr11772833772924E073-37958
chr11775008775954E073-34928
chr11778786778866E073-32016
chr11778878778990E073-31892
chr11779041779261E073-31621
chr11779293779616E073-31266
chr11779619779776E073-31106
chr11779811779900E073-30982
chr11779930780125E073-30757
chr11780217780315E073-30567
chr11780321780361E073-30521
chr11780399780492E073-30390
chr11783370784241E073-26641
chr11785044785136E073-25746
chr11785293785337E073-25545
chr11785954786034E073-24848
chr11786105786190E073-24692
chr11786217786267E073-24615
chr11786324786378E073-24504
chr11786409786611E073-24271
chr11786661786712E073-24170
chr11786833786984E073-23898
chr11787055787175E073-23707
chr11787180787380E073-23502
chr11787407787592E073-23290
chr11787641787729E073-23153
chr11787747787803E073-23079
chr11787852787935E073-22947
chr11787986788159E073-22723
chr11788166788267E073-22615
chr11788283788451E073-22431
chr11788544788603E073-22279
chr11788685788733E073-22149
chr11788757788839E073-22043
chr11793350794013E073-16869
chr11798811798876E073-12006
chr11798996799393E073-11489
chr11803550803788E073-7094
chr11811429812418E073547
chr11839900841657E07329018
chr11854632854741E07343750
chr11854858854989E07343976
chr11855099855430E07344217
chr11855505855641E07344623
chr11855785856113E07344903
chr11856162856212E07345280
chr11856232856419E07345350
chr11860410860523E07349528
chr11761685761879E074-49003
chr11761975762015E074-48867
chr11762139762189E074-48693
chr11762288763622E074-47260
chr11764999765081E074-45801
chr11765118765640E074-45242
chr11771654771708E074-39174
chr11771767771897E074-38985
chr11771964772195E074-38687
chr11772467772517E074-38365
chr11772664772728E074-38154
chr11772966773229E074-37653
chr11773359773423E074-37459
chr11773474773524E074-37358
chr11773660773790E074-37092
chr11773804774001E074-36881
chr11774037774168E074-36714
chr11775008775954E074-34928
chr11783166783235E074-27647
chr11783370784241E074-26641
chr11788757788839E074-22043
chr11788895789014E074-21868
chr11789029789170E074-21712
chr11859553860304E07448671
chr11775008775954E081-34928
chr11778786778866E081-32016
chr11778878778990E081-31892
chr11779041779261E081-31621
chr11782409782544E081-28338
chr11782547782587E081-28295
chr11782652782712E081-28170
chr11782822783126E081-27756
chr11783166783235E081-27647
chr11783370784241E081-26641
chr11784568784701E081-26181
chr11785044785136E081-25746
chr11785293785337E081-25545
chr11787747787803E081-23079
chr11787852787935E081-22947
chr11787986788159E081-22723
chr11788166788267E081-22615
chr11788283788451E081-22431
chr11788544788603E081-22279
chr11788685788733E081-22149
chr11788757788839E081-22043
chr11788895789014E081-21868
chr11789029789170E081-21712
chr11790505791483E081-19399
chr11794043794710E081-16172
chr11794737794810E081-16072
chr11811429812418E081547
chr11823752823915E08112870
chr11823923824235E08113041
chr11835470835614E08124588
chr11839900841657E08129018
chr11851279851799E08140397
chr11851825851959E08140943
chr11852049852241E08141167
chr11852457852507E08141575
chr11852512852687E08141630
chr11852716852861E08141834
chr11853062853114E08142180
chr11853122853252E08142240
chr11853492853690E08142610
chr11854356854477E08143474
chr11854632854741E08143750
chr11854858854989E08143976
chr11855099855430E08144217
chr11855505855641E08144623
chr11855785856113E08144903
chr11856162856212E08145280
chr11856232856419E08145350
chr11856538856880E08145656
chr11856923857420E08146041
chr11857724857923E08146842
chr11857935858289E08147053
chr11858325859057E08147443
chr11859128859317E08148246
chr11859403859479E08148521
chr11859553860304E08148671
chr11860410860523E08149528
chr11778786778866E082-32016
chr11778878778990E082-31892
chr11779041779261E082-31621
chr11779293779616E082-31266
chr11779619779776E082-31106
chr11779811779900E082-30982
chr11779930780125E082-30757
chr11780217780315E082-30567
chr11780321780361E082-30521
chr11780399780492E082-30390
chr11780557780653E082-30229
chr11784568784701E082-26181
chr11785044785136E082-25746
chr11785293785337E082-25545
chr11788283788451E082-22431
chr11788544788603E082-22279
chr11793350794013E082-16869
chr11794043794710E082-16172
chr11794737794810E082-16072
chr11811429812418E082547
chr11851279851799E08240397
chr11856162856212E08245280
chr11856232856419E08245350
chr11856538856880E08245656










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr11776294778670E067-32212
chr11790010790327E067-20555
chr11790352790402E067-20480
chr11808498810615E067-267
chr11810672810745E067-137
chr11776294778670E068-32212
chr11790010790327E068-20555
chr11790352790402E068-20480
chr11808498810615E068-267
chr11810672810745E068-137
chr11826751834264E06815869
chr11841798847146E06830916
chr11849186849948E06838304
chr11849957850557E06839075
chr11776294778670E069-32212
chr11790010790327E069-20555
chr11790352790402E069-20480
chr11808498810615E069-267
chr11810672810745E069-137
chr11849186849948E06938304
chr11849957850557E06939075
chr11776294778670E070-32212
chr11790010790327E070-20555
chr11790352790402E070-20480
chr11808498810615E070-267
chr11810672810745E070-137
chr11841798847146E07030916
chr11849186849948E07038304
chr11849957850557E07039075
chr11776294778670E071-32212
chr11808498810615E071-267
chr11810672810745E071-137
chr11841798847146E07130916
chr11849957850557E07139075
chr11776294778670E072-32212
chr11790010790327E072-20555
chr11790352790402E072-20480
chr11808498810615E072-267
chr11810672810745E072-137
chr11776294778670E073-32212
chr11808498810615E073-267
chr11810672810745E073-137
chr11841798847146E07330916
chr11849186849948E07338304
chr11849957850557E07339075
chr11776294778670E074-32212
chr11808498810615E074-267
chr11810672810745E074-137
chr11841798847146E07430916
chr11808498810615E081-267
chr11776294778670E082-32212
chr11790010790327E082-20555
chr11790352790402E082-20480
chr11808498810615E082-267
chr11810672810745E082-137
chr11841798847146E08230916
chr11849186849948E08238304
chr11849957850557E08239075