rs10902443

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G==0191 (5730/29884,GnomAD)
G==0248 (7248/29118,TOPMED)
G==0265 (1325/5008,1000G)
G==0103 (396/3854,ALSPAC)
G==0111 (410/3708,TWINSUK)

Position: chr12:131566145 (GRCh38.p7) (12q24.33)

Phenotype: ND

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 130 Enhancers around

Promoter: 0 Promoter around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 12	NC_000012.12:g.131566145G>A
GRCh37.p13 chr 12	NC_000012.11:g.132050690G>A
GRCh38.p7 chr 12 alt locus HSCHR12_7_CTG2_1	NT_187591.1:g.23126G>A

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.402	A=0.598
1000Genomes	American	Sub	694	G=0.210	A=0.790
1000Genomes	East Asian	Sub	1008	G=0.390	A=0.610
1000Genomes	Europe	Sub	1006	G=0.118	A=0.882
1000Genomes	Global	Study-wide	5008	G=0.265	A=0.735
1000Genomes	South Asian	Sub	978	G=0.140	A=0.860
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.103	A=0.897
The Genome Aggregation Database	African	Sub	8666	G=0.362	A=0.638
The Genome Aggregation Database	American	Sub	838	G=0.230	A=0.770
The Genome Aggregation Database	East Asian	Sub	1610	G=0.403	A=0.597
The Genome Aggregation Database	Europe	Sub	18468	G=0.091	A=0.908
The Genome Aggregation Database	Global	Study-wide	29884	G=0.191	A=0.808
The Genome Aggregation Database	Other	Sub	302	G=0.210	A=0.790
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.248	A=0.751
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.111	A=0.889

PMID	Title	Author	Journal
23643383	Genome-wide association analysis for multiple continuous secondary phenotypes.	Schifano ED	Am J Hum Genet

P-Value

SNP ID	p-value	Traits	Study
rs10902443	9.27E-06	nicotine dependence (smoking)	23643383

eQTL of rs10902443 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs10902443 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr12	132067800	132068197	E067	17110
chr12	132092368	132092436	E067	41678
chr12	132092525	132092629	E067	41835
chr12	132092636	132092689	E067	41946
chr12	132092734	132092886	E067	42044
chr12	132092961	132093014	E067	42271
chr12	132093168	132093277	E067	42478
chr12	132093403	132094250	E067	42713
chr12	132100200	132100486	E067	49510
chr12	132092368	132092436	E068	41678
chr12	132092525	132092629	E068	41835
chr12	132092636	132092689	E068	41946
chr12	132092734	132092886	E068	42044
chr12	132092961	132093014	E068	42271
chr12	132093168	132093277	E068	42478
chr12	132093403	132094250	E068	42713
chr12	132094325	132094650	E068	43635
chr12	132097642	132097766	E068	46952
chr12	132097779	132097847	E068	47089
chr12	132098051	132098130	E068	47361
chr12	132098321	132098371	E068	47631
chr12	132100200	132100486	E068	49510
chr12	132093403	132094250	E069	42713
chr12	132094325	132094650	E069	43635
chr12	132097642	132097766	E069	46952
chr12	132097779	132097847	E069	47089
chr12	132098051	132098130	E069	47361
chr12	132098321	132098371	E069	47631
chr12	132100009	132100154	E069	49319
chr12	132100200	132100486	E069	49510
chr12	132032034	132032084	E070	-18606
chr12	132032207	132032358	E070	-18332
chr12	132089458	132089547	E071	38768
chr12	132093403	132094250	E071	42713
chr12	132094325	132094650	E071	43635
chr12	132097642	132097766	E071	46952
chr12	132097779	132097847	E071	47089
chr12	132098051	132098130	E071	47361
chr12	132098321	132098371	E071	47631
chr12	132099005	132099061	E071	48315
chr12	132099842	132099892	E071	49152
chr12	132100009	132100154	E071	49319
chr12	132100200	132100486	E071	49510
chr12	132093403	132094250	E072	42713
chr12	132094325	132094650	E072	43635
chr12	132097642	132097766	E072	46952
chr12	132097779	132097847	E072	47089
chr12	132098051	132098130	E072	47361
chr12	132098321	132098371	E072	47631
chr12	132099005	132099061	E072	48315
chr12	132099842	132099892	E072	49152
chr12	132100009	132100154	E072	49319
chr12	132100200	132100486	E072	49510
chr12	132093403	132094250	E073	42713
chr12	132094325	132094650	E073	43635
chr12	132097642	132097766	E073	46952
chr12	132097779	132097847	E073	47089
chr12	132098051	132098130	E073	47361
chr12	132099842	132099892	E073	49152
chr12	132100009	132100154	E073	49319
chr12	132100200	132100486	E073	49510
chr12	132058740	132058853	E074	8050
chr12	132058976	132059046	E074	8286
chr12	132093403	132094250	E074	42713
chr12	132094325	132094650	E074	43635
chr12	132097642	132097766	E074	46952
chr12	132097779	132097847	E074	47089
chr12	132098051	132098130	E074	47361
chr12	132098321	132098371	E074	47631
chr12	132100200	132100486	E074	49510
chr12	132027431	132027481	E081	-23209
chr12	132060156	132060206	E081	9466
chr12	132062423	132062498	E081	11733
chr12	132063076	132063185	E081	12386
chr12	132063277	132063388	E081	12587
chr12	132063487	132063669	E081	12797
chr12	132083984	132084055	E081	33294
chr12	132084086	132084169	E081	33396
chr12	132086795	132087036	E081	36105
chr12	132089458	132089547	E081	38768
chr12	132089954	132090016	E081	39264
chr12	132090096	132090263	E081	39406
chr12	132091992	132092046	E081	41302
chr12	132092141	132092361	E081	41451
chr12	132092368	132092436	E081	41678
chr12	132092525	132092629	E081	41835
chr12	132092636	132092689	E081	41946
chr12	132092734	132092886	E081	42044
chr12	132092961	132093014	E081	42271
chr12	132093168	132093277	E081	42478
chr12	132093403	132094250	E081	42713
chr12	132094325	132094650	E081	43635
chr12	132094901	132094955	E081	44211
chr12	132094979	132095029	E081	44289
chr12	132095038	132095098	E081	44348
chr12	132095127	132095171	E081	44437
chr12	132095416	132095511	E081	44726
chr12	132095600	132095662	E081	44910
chr12	132095868	132095960	E081	45178
chr12	132096250	132096290	E081	45560
chr12	132100009	132100154	E081	49319
chr12	132100200	132100486	E081	49510
chr12	132036867	132037634	E082	-13056
chr12	132058740	132058853	E082	8050
chr12	132058976	132059046	E082	8286
chr12	132059071	132059136	E082	8381
chr12	132059172	132059253	E082	8482
chr12	132060156	132060206	E082	9466
chr12	132060235	132060370	E082	9545
chr12	132060525	132060591	E082	9835
chr12	132063277	132063388	E082	12587
chr12	132063487	132063669	E082	12797
chr12	132067800	132068197	E082	17110
chr12	132083984	132084055	E082	33294
chr12	132084086	132084169	E082	33396
chr12	132091992	132092046	E082	41302
chr12	132092141	132092361	E082	41451
chr12	132092368	132092436	E082	41678
chr12	132092525	132092629	E082	41835
chr12	132092636	132092689	E082	41946
chr12	132092734	132092886	E082	42044
chr12	132092961	132093014	E082	42271
chr12	132093168	132093277	E082	42478
chr12	132093403	132094250	E082	42713
chr12	132094325	132094650	E082	43635
chr12	132094901	132094955	E082	44211
chr12	132094979	132095029	E082	44289
chr12	132095038	132095098	E082	44348
chr12	132095127	132095171	E082	44437
chr12	132095416	132095511	E082	44726