rs10922323

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0426 (12762/29904,GnomAD)
C=0459 (13390/29118,TOPMED)
C=0436 (2182/5008,1000G)
C=0399 (1537/3854,ALSPAC)
C=0411 (1524/3708,TWINSUK)
chr1:197893191 (GRCh38.p7) (1q31.3)
AD
GWASdb2
2   publication(s)
See rs on genome
1 Enhancer around
11 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 1NC_000001.11:g.197893191T>C
GRCh37.p13 chr 1NC_000001.10:g.197862321T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.444C=0.556
1000GenomesAmericanSub694T=0.660C=0.340
1000GenomesEast AsianSub1008T=0.652C=0.348
1000GenomesEuropeSub1006T=0.578C=0.422
1000GenomesGlobalStudy-wide5008T=0.564C=0.436
1000GenomesSouth AsianSub978T=0.560C=0.440
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.601C=0.399
The Genome Aggregation DatabaseAfricanSub8702T=0.498C=0.502
The Genome Aggregation DatabaseAmericanSub834T=0.640C=0.360
The Genome Aggregation DatabaseEast AsianSub1618T=0.688C=0.312
The Genome Aggregation DatabaseEuropeSub18448T=0.596C=0.403
The Genome Aggregation DatabaseGlobalStudy-wide29904T=0.573C=0.426
The Genome Aggregation DatabaseOtherSub302T=0.560C=0.440
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.540C=0.459
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.589C=0.411
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res
23691058Dosage transmission disequilibrium test (dTDT) for linkage and association detection.Zhang ZPLoS One

P-Value

SNP ID p-value Traits Study
rs109223230.00000646alcohol dependence23691058
rs109223230.00036alcohol dependence20201924

eQTL of rs10922323 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10922323 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr1197883768197883932E08121447

Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr1197871298197872621E0678977
chr1197871298197872621E0688977
chr1197884124197887887E06821803
chr1197871298197872621E0698977
chr1197871298197872621E0708977
chr1197871298197872621E0718977
chr1197871298197872621E0728977
chr1197871298197872621E0738977
chr1197871298197872621E0748977
chr1197871298197872621E0818977
chr1197871298197872621E0828977