rs10928122

Homo sapiens
G>A / G>T
LRP1B : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0307 (9204/29948,GnomAD)
T=0337 (9821/29118,TOPMED)
T=0281 (1407/5008,1000G)
T=0261 (1005/3854,ALSPAC)
T=0284 (1053/3708,TWINSUK)
chr2:141772551 (GRCh38.p7) (2q22.2)
AD
GWASdb2
1   publication(s)
See rs on genome

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.141772551G>A
GRCh38.p7 chr 2NC_000002.12:g.141772551G>T
GRCh37.p13 chr 2NC_000002.11:g.142530120G>A
GRCh37.p13 chr 2NC_000002.11:g.142530120G>T

Gene: LRP1B, LDL receptor related protein 1B(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LRP1B transcriptNM_018557.2:c.N/AIntron Variant
LRP1B transcript variant X1XM_017004341.1:c.N/AIntron Variant
LRP1B transcript variant X3XM_017004342.1:c.N/AGenic Upstream Transcript Variant
LRP1B transcript variant X2XR_001738778.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.544T=0.456
1000GenomesAmericanSub694G=0.770T=0.230
1000GenomesEast AsianSub1008G=0.868T=0.132
1000GenomesEuropeSub1006G=0.734T=0.266
1000GenomesGlobalStudy-wide5008G=0.719T=0.281
1000GenomesSouth AsianSub978G=0.750T=0.250
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.739T=0.261
The Genome Aggregation DatabaseAfricanSub8710G=0.576T=0.424
The Genome Aggregation DatabaseAmericanSub838G=0.790T=0.21,
The Genome Aggregation DatabaseEast AsianSub1620G=0.848T=0.152
The Genome Aggregation DatabaseEuropeSub18480G=0.728T=0.271
The Genome Aggregation DatabaseGlobalStudy-wide29948G=0.692T=0.307
The Genome Aggregation DatabaseOtherSub300G=0.750T=0.25,
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.662T=0.337
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.716T=0.284
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs109281220.000663alcohol dependence20201924

eQTL of rs10928122 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10928122 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr24778533347785484E067-34488
chr24778558347786154E067-33818
chr24778627847786437E067-33535
chr24784429747844875E06724325
chr24784488647845021E06724914
chr24784809847848175E06728126
chr24784429747844875E06824325
chr24778533347785484E069-34488
chr24778558347786154E069-33818
chr24784352347844133E06923551
chr24784429747844875E06924325
chr24784488647845021E06924914
chr24784519347845243E06925221
chr24784809847848175E06928126
chr24778472947784856E070-35116
chr24778533347785484E070-34488
chr24778558347786154E070-33818
chr24778627847786437E070-33535
chr24778654447786655E070-33317
chr24786866647868724E07048694
chr24778533347785484E071-34488
chr24778558347786154E071-33818
chr24778627847786437E071-33535
chr24778654447786655E071-33317
chr24779543747795914E071-24058
chr24784352347844133E07123551
chr24784429747844875E07124325
chr24784488647845021E07124914
chr24784519347845243E07125221
chr24784528747845361E07125315
chr24784809847848175E07128126
chr24778472947784856E072-35116
chr24778533347785484E072-34488
chr24778558347786154E072-33818
chr24778917947789356E072-30616
chr24784352347844133E07223551
chr24784429747844875E07224325
chr24784488647845021E07224914
chr24784519347845243E07225221
chr24784528747845361E07225315
chr24778533347785484E073-34488
chr24778558347786154E073-33818
chr24778627847786437E073-33535
chr24784352347844133E07423551
chr24784429747844875E07424325
chr24784488647845021E07424914
chr24784519347845243E07425221
chr24784528747845361E07425315
chr24778035947780459E081-39513
chr24778472947784856E081-35116
chr24778533347785484E081-34488
chr24778558347786154E081-33818
chr24778627847786437E081-33535
chr24778654447786655E081-33317
chr24779369047793861E081-26111
chr24779543747795914E081-24058
chr24779543747795914E082-24058










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr24779688547797111E067-22861
chr24779712147797374E067-22598
chr24779787247798990E067-20982
chr24779688547797111E068-22861
chr24779712147797374E068-22598
chr24779787247798990E068-20982
chr24779688547797111E069-22861
chr24779712147797374E069-22598
chr24779787247798990E069-20982
chr24779712147797374E071-22598
chr24779787247798990E071-20982
chr24779712147797374E072-22598
chr24779787247798990E072-20982
chr24779688547797111E073-22861
chr24779712147797374E073-22598
chr24779787247798990E073-20982
chr24779712147797374E074-22598
chr24779787247798990E074-20982
chr24779688547797111E082-22861
chr24779712147797374E082-22598