rs10935045

Homo sapiens
C>A
TMEM108 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0151 (4547/29950,GnomAD)
A=0133 (3880/29118,TOPMED)
A=0170 (852/5008,1000G)
A=0130 (500/3854,ALSPAC)
A=0132 (489/3708,TWINSUK)
chr3:133081302 (GRCh38.p7) (3q22.1)
AD
GWASdb2
1   publication(s)
See rs on genome
70 Enhancers around
25 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.133081302C>A
GRCh37.p13 chr 3NC_000003.11:g.132800146C>A

Gene: TMEM108, transmembrane protein 108(plus strand)

Molecule type Change Amino acid[Codon] SO Term
TMEM108 transcript variant 2NM_001136469.2:c.N/AIntron Variant
TMEM108 transcript variant 1NM_023943.3:c.N/AIntron Variant
TMEM108 transcript variant 3NM_001282865.1:c.N/AGenic Upstream Transcript Variant
TMEM108 transcript variant X2XM_011513098.2:c.N/AIntron Variant
TMEM108 transcript variant X3XM_017007080.1:c.N/AIntron Variant
TMEM108 transcript variant X4XM_017007081.1:c.N/AIntron Variant
TMEM108 transcript variant X1XM_011513097.2:c.N/AGenic Upstream Transcript Variant
TMEM108 transcript variant X5XM_017007082.1:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.833A=0.167
1000GenomesAmericanSub694C=0.820A=0.180
1000GenomesEast AsianSub1008C=0.811A=0.189
1000GenomesEuropeSub1006C=0.855A=0.145
1000GenomesGlobalStudy-wide5008C=0.830A=0.170
1000GenomesSouth AsianSub978C=0.830A=0.170
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.870A=0.130
The Genome Aggregation DatabaseAfricanSub8718C=0.855A=0.145
The Genome Aggregation DatabaseAmericanSub836C=0.810A=0.190
The Genome Aggregation DatabaseEast AsianSub1606C=0.826A=0.174
The Genome Aggregation DatabaseEuropeSub18488C=0.847A=0.152
The Genome Aggregation DatabaseGlobalStudy-wide29950C=0.848A=0.151
The Genome Aggregation DatabaseOtherSub302C=0.930A=0.070
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.866A=0.133
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.868A=0.132
PMID Title Author Journal
21529783A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.Heath ACBiol Psychiatry

P-Value

SNP ID p-value Traits Study
rs109350451.7E-06alcoholism (heaviness of drinking)21529783

eQTL of rs10935045 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10935045 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr3132773413132773902E067-26244
chr3132774268132774338E067-25808
chr3132774356132774413E067-25733
chr3132774504132774595E067-25551
chr3132837932132838463E06737786
chr3132759479132760535E068-39611
chr3132760593132760682E068-39464
chr3132760593132760682E069-39464
chr3132838788132838869E06938642
chr3132751314132751472E070-48674
chr3132773413132773902E070-26244
chr3132774268132774338E070-25808
chr3132774356132774413E070-25733
chr3132774504132774595E070-25551
chr3132815877132815999E07015731
chr3132837932132838463E07037786
chr3132838788132838869E07038642
chr3132843348132843770E07043202
chr3132843348132843770E07143202
chr3132843348132843770E07343202
chr3132759479132760535E074-39611
chr3132760593132760682E074-39464
chr3132836054132836108E07435908
chr3132837932132838463E07437786
chr3132840485132840593E07440339
chr3132768416132768641E081-31505
chr3132769259132769309E081-30837
chr3132773413132773902E081-26244
chr3132774268132774338E081-25808
chr3132774356132774413E081-25733
chr3132774504132774595E081-25551
chr3132777238132777396E081-22750
chr3132777930132778004E081-22142
chr3132784119132784227E081-15919
chr3132784475132784615E081-15531
chr3132784632132784766E081-15380
chr3132784805132785151E081-14995
chr3132786092132786194E081-13952
chr3132788492132788562E081-11584
chr3132789103132789168E081-10978
chr3132793845132794128E081-6018
chr3132823069132823478E08122923
chr3132825145132825239E08124999
chr3132826336132826625E08126190
chr3132832996132833040E08132850
chr3132833219132833273E08133073
chr3132837932132838463E08137786
chr3132840485132840593E08140339
chr3132843348132843770E08143202
chr3132768416132768641E082-31505
chr3132773413132773902E082-26244
chr3132777238132777396E082-22750
chr3132777930132778004E082-22142
chr3132784119132784227E082-15919
chr3132784475132784615E082-15531
chr3132784632132784766E082-15380
chr3132784805132785151E082-14995
chr3132786092132786194E082-13952
chr3132789103132789168E082-10978
chr3132815877132815999E08215731
chr3132816229132816351E08216083
chr3132828815132828867E08228669
chr3132828918132828972E08228772
chr3132829019132829098E08228873
chr3132832842132832982E08232696
chr3132832996132833040E08232850
chr3132833219132833273E08233073
chr3132834391132834441E08234245
chr3132840164132840451E08240018
chr3132840485132840593E08240339









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr3132756400132756626E067-43520
chr3132756631132758314E067-41832
chr3132756400132756626E068-43520
chr3132756631132758314E068-41832
chr3132844154132844283E06844008
chr3132756400132756626E069-43520
chr3132756631132758314E069-41832
chr3132756400132756626E070-43520
chr3132756631132758314E070-41832
chr3132756400132756626E071-43520
chr3132756631132758314E071-41832
chr3132756400132756626E072-43520
chr3132756631132758314E072-41832
chr3132844154132844283E07244008
chr3132756400132756626E073-43520
chr3132756631132758314E073-41832
chr3132844154132844283E07344008
chr3132756400132756626E074-43520
chr3132756631132758314E074-41832
chr3132756400132756626E081-43520
chr3132756631132758314E081-41832
chr3132844154132844283E08144008
chr3132756400132756626E082-43520
chr3132756631132758314E082-41832
chr3132844154132844283E08244008