rs10940051

Homo sapiens
C>T
NLN : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0248 (7381/29690,GnomAD)
T=0269 (7850/29118,TOPMED)
T=0277 (1387/5008,1000G)
chr5:65811762 (GRCh38.p7) (5q12.3)
AD
GWASCatalog
1   publication(s)
See rs on genome
239 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.65811762C>T
GRCh37.p13 chr 5NC_000005.9:g.65107589C>T

Gene: NLN, neurolysin(plus strand)

Molecule type Change Amino acid[Codon] SO Term
NLN transcriptNM_020726.4:c.N/AIntron Variant
NLN transcript variant X1XM_005248559.2:c.N/AIntron Variant
NLN transcript variant X2XM_006714661.2:c.N/AIntron Variant
NLN transcript variant X3XM_017009673.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.627T=0.373
1000GenomesAmericanSub694C=0.720T=0.280
1000GenomesEast AsianSub1008C=0.740T=0.260
1000GenomesEuropeSub1006C=0.796T=0.204
1000GenomesGlobalStudy-wide5008C=0.723T=0.277
1000GenomesSouth AsianSub978C=0.760T=0.240
The Genome Aggregation DatabaseAfricanSub8606C=0.665T=0.335
The Genome Aggregation DatabaseAmericanSub834C=0.640T=0.360
The Genome Aggregation DatabaseEast AsianSub1588C=0.742T=0.258
The Genome Aggregation DatabaseEuropeSub18364C=0.798T=0.201
The Genome Aggregation DatabaseGlobalStudy-wide29690C=0.751T=0.248
The Genome Aggregation DatabaseOtherSub298C=0.690T=0.310
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.730T=0.269
PMID Title Author Journal
29071344Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.Zhou HJAMA Psychiatry

P-Value

SNP ID p-value Traits Study
rs109400516E-06alcohol dependence29071344

eQTL of rs10940051 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10940051 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr56506494965065053E067-42536
chr56506542165065723E067-41866
chr56506703965067587E067-40002
chr56507132865071650E067-35939
chr56507259165072993E067-34596
chr56508777665087871E067-19718
chr56509585265096083E067-11506
chr56509673165096852E067-10737
chr56509843065098480E067-9109
chr56510404965104486E067-3103
chr56511385265113998E0676263
chr56511436265114450E0676773
chr56511445865114712E0676869
chr56511509165115174E0677502
chr56511522265115320E0677633
chr56511535465115416E0677765
chr56511830465118359E06710715
chr56511864665118806E06711057
chr56511916265119292E06711573
chr56512397965124250E06716390
chr56512433365124702E06716744
chr56512470365124777E06717114
chr56512845265129073E06720863
chr56513025965130349E06722670
chr56513105165131301E06723462
chr56506494965065053E068-42536
chr56506703965067587E068-40002
chr56507132865071650E068-35939
chr56507259165072993E068-34596
chr56509585265096083E068-11506
chr56509673165096852E068-10737
chr56509843065098480E068-9109
chr56510404965104486E068-3103
chr56510450665104752E068-2837
chr56510479665104962E068-2627
chr56510584465105925E068-1664
chr56510601665106355E068-1234
chr56511100365111120E0683414
chr56511116365111236E0683574
chr56511271465112902E0685125
chr56511385265113998E0686263
chr56511509165115174E0687502
chr56511522265115320E0687633
chr56511535465115416E0687765
chr56511753665117596E0689947
chr56511830465118359E06810715
chr56511864665118806E06811057
chr56511916265119292E06811573
chr56512397965124250E06816390
chr56512495865125008E06817369
chr56512603265126736E06818443
chr56512674965126987E06819160
chr56512752865127578E06819939
chr56512845265129073E06820863
chr56513025965130349E06822670
chr56513105165131301E06823462
chr56506494965065053E069-42536
chr56506542165065723E069-41866
chr56506703965067587E069-40002
chr56506825065068344E069-39245
chr56507259165072993E069-34596
chr56508777665087871E069-19718
chr56508791365087991E069-19598
chr56508828765088457E069-19132
chr56509211465092411E069-15178
chr56509585265096083E069-11506
chr56509673165096852E069-10737
chr56509714365097554E069-10035
chr56509843065098480E069-9109
chr56510404965104486E069-3103
chr56510450665104752E069-2837
chr56510479665104962E069-2627
chr56510584465105925E069-1664
chr56510601665106355E069-1234
chr56511271465112902E0695125
chr56511385265113998E0696263
chr56511509165115174E0697502
chr56511522265115320E0697633
chr56511535465115416E0697765
chr56511753665117596E0699947
chr56511830465118359E06910715
chr56511864665118806E06911057
chr56511916265119292E06911573
chr56512397965124250E06916390
chr56512433365124702E06916744
chr56512470365124777E06917114
chr56512495865125008E06917369
chr56512603265126736E06918443
chr56512674965126987E06919160
chr56512752865127578E06919939
chr56512845265129073E06920863
chr56513025965130349E06922670
chr56513105165131301E06923462
chr56511271465112902E0705125
chr56511385265113998E0706263
chr56512603265126736E07018443
chr56512674965126987E07019160
chr56505817965058279E071-49310
chr56506494965065053E071-42536
chr56506542165065723E071-41866
chr56506703965067587E071-40002
chr56507259165072993E071-34596
chr56508671965086831E071-20758
chr56508690865086963E071-20626
chr56508777665087871E071-19718
chr56508791365087991E071-19598
chr56508828765088457E071-19132
chr56509374465093820E071-13769
chr56509585265096083E071-11506
chr56509673165096852E071-10737
chr56509843065098480E071-9109
chr56509884465098894E071-8695
chr56509909965099203E071-8386
chr56510450665104752E071-2837
chr56510479665104962E071-2627
chr56510584465105925E071-1664
chr56510601665106355E071-1234
chr56511271465112902E0715125
chr56511385265113998E0716263
chr56511753665117596E0719947
chr56511830465118359E07110715
chr56511864665118806E07111057
chr56512180965122097E07114220
chr56512397965124250E07116390
chr56512433365124702E07116744
chr56512470365124777E07117114
chr56512495865125008E07117369
chr56512603265126736E07118443
chr56512674965126987E07119160
chr56512845265129073E07120863
chr56513025965130349E07122670
chr56513105165131301E07123462
chr56506494965065053E072-42536
chr56507132865071650E072-35939
chr56507259165072993E072-34596
chr56508828765088457E072-19132
chr56509585265096083E072-11506
chr56509673165096852E072-10737
chr56509714365097554E072-10035
chr56509843065098480E072-9109
chr56510404965104486E072-3103
chr56510450665104752E072-2837
chr56510479665104962E072-2627
chr56510584465105925E072-1664
chr56510601665106355E072-1234
chr56510640765106457E072-1132
chr56510649365106547E072-1042
chr56511385265113998E0726263
chr56511436265114450E0726773
chr56511445865114712E0726869
chr56511509165115174E0727502
chr56511522265115320E0727633
chr56511535465115416E0727765
chr56511753665117596E0729947
chr56511830465118359E07210715
chr56511864665118806E07211057
chr56511916265119292E07211573
chr56512397965124250E07216390
chr56512433365124702E07216744
chr56512470365124777E07217114
chr56512495865125008E07217369
chr56512603265126736E07218443
chr56512674965126987E07219160
chr56512752865127578E07219939
chr56512845265129073E07220863
chr56513105165131301E07223462
chr56507259165072993E073-34596
chr56509673165096852E073-10737
chr56509714365097554E073-10035
chr56510404965104486E073-3103
chr56510450665104752E073-2837
chr56510479665104962E073-2627
chr56510584465105925E073-1664
chr56510601665106355E073-1234
chr56511385265113998E0736263
chr56511436265114450E0736773
chr56512397965124250E07316390
chr56512433365124702E07316744
chr56512752865127578E07319939
chr56512845265129073E07320863
chr56513025965130349E07322670
chr56506494965065053E074-42536
chr56506542165065723E074-41866
chr56506703965067587E074-40002
chr56506825065068344E074-39245
chr56507132865071650E074-35939
chr56508777665087871E074-19718
chr56508791365087991E074-19598
chr56509211465092411E074-15178
chr56509585265096083E074-11506
chr56509673165096852E074-10737
chr56509714365097554E074-10035
chr56509843065098480E074-9109
chr56509884465098894E074-8695
chr56509909965099203E074-8386
chr56510404965104486E074-3103
chr56510450665104752E074-2837
chr56510479665104962E074-2627
chr56510584465105925E074-1664
chr56510601665106355E074-1234
chr56511271465112902E0745125
chr56511385265113998E0746263
chr56511436265114450E0746773
chr56511445865114712E0746869
chr56511753665117596E0749947
chr56511830465118359E07410715
chr56511933365120361E07411744
chr56512397965124250E07416390
chr56512433365124702E07416744
chr56512470365124777E07417114
chr56512495865125008E07417369
chr56512603265126736E07418443
chr56512674965126987E07419160
chr56512845265129073E07420863
chr56513025965130349E07422670
chr56508777665087871E081-19718
chr56508791365087991E081-19598
chr56508828765088457E081-19132
chr56509211465092411E081-15178
chr56510404965104486E081-3103
chr56510450665104752E081-2837
chr56510479665104962E081-2627
chr56510584465105925E081-1664
chr56510601665106355E081-1234
chr56510640765106457E081-1132
chr56510649365106547E081-1042
chr56510689365107179E081-410
chr56511436265114450E0816773
chr56511445865114712E0816869
chr56512603265126736E08118443
chr56512674965126987E08119160
chr56512752865127578E08119939
chr56515173165151978E08144142
chr56510404965104486E082-3103
chr56510450665104752E082-2837
chr56510584465105925E082-1664
chr56512397965124250E08216390
chr56512433365124702E08216744
chr56512674965126987E08219160