rs10940373

Homo sapiens
A>G
ARL15 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0354 (10623/29954,GnomAD)
A==0392 (11431/29118,TOPMED)
A==0453 (2270/5008,1000G)
A==0265 (1023/3854,ALSPAC)
A==0260 (964/3708,TWINSUK)
chr5:54279861 (GRCh38.p7) (5q11.2)
AD
GWASdb2
1   publication(s)
See rs on genome
26 Enhancers around
11 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.54279861A>G
GRCh37.p13 chr 5NC_000005.9:g.53575691A>G

Gene: ARL15, ADP ribosylation factor like GTPase 15(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ARL15 transcriptNM_019087.2:c.N/AIntron Variant
ARL15 transcript variant X1XM_011543498.2:c.N/AIntron Variant
ARL15 transcript variant X2XM_011543499.2:c.N/AIntron Variant
ARL15 transcript variant X3XM_011543500.2:c.N/AIntron Variant
ARL15 transcript variant X4XM_017009598.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.522G=0.478
1000GenomesAmericanSub694A=0.530G=0.470
1000GenomesEast AsianSub1008A=0.576G=0.424
1000GenomesEuropeSub1006A=0.283G=0.717
1000GenomesGlobalStudy-wide5008A=0.453G=0.547
1000GenomesSouth AsianSub978A=0.360G=0.640
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.265G=0.735
The Genome Aggregation DatabaseAfricanSub8706A=0.494G=0.506
The Genome Aggregation DatabaseAmericanSub836A=0.510G=0.490
The Genome Aggregation DatabaseEast AsianSub1618A=0.609G=0.391
The Genome Aggregation DatabaseEuropeSub18492A=0.261G=0.738
The Genome Aggregation DatabaseGlobalStudy-wide29954A=0.354G=0.645
The Genome Aggregation DatabaseOtherSub302A=0.230G=0.770
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.392G=0.607
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.260G=0.740
PMID Title Author Journal
24962325Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.Kapoor MDrug Alcohol Depend

P-Value

SNP ID p-value Traits Study
rs109403731.6E-06alcohol dependence (age at onset)24962325

eQTL of rs10940373 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10940373 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr55359219153592302E06716500
chr55359230553592489E06716614
chr55360474653604828E06729055
chr55359156353591979E06815872
chr55359219153592302E06816500
chr55359230553592489E06816614
chr55357394153574185E069-1506
chr55357422253574433E069-1258
chr55360335753603465E07027666
chr55360351753603786E07027826
chr55360440353604546E07028712
chr55360474653604828E07129055
chr55357394153574185E072-1506
chr55357422253574433E072-1258
chr55357444553574505E072-1186
chr55357422253574433E074-1258
chr55357444553574505E074-1186
chr55359119253591246E07415501
chr55359156353591979E07415872
chr55359219153592302E07416500
chr55359230553592489E07416614
chr55360351753603786E08127826
chr55360427953604329E08128588
chr55360440353604546E08128712
chr55360474653604828E08129055
chr55360803253608085E08132341








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr55360503053607991E06729339
chr55360503053607991E06829339
chr55360503053607991E06929339
chr55360503053607991E07029339
chr55355060653550896E071-24795
chr55360503053607991E07129339
chr55360503053607991E07229339
chr55360503053607991E07329339
chr55360503053607991E07429339
chr55360503053607991E08129339
chr55360503053607991E08229339