rs10953545

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
T==0288 (8640/29946,GnomAD)
T==0312 (9112/29118,TOPMED)
T==0223 (1116/5008,1000G)
T==0296 (1141/3854,ALSPAC)
T==0297 (1102/3708,TWINSUK)
chr7:107731890 (GRCh38.p7) (7q22.3)
AD
GWASdb2
1   publication(s)
See rs on genome

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.107731890T>C
GRCh37.p13 chr 7NC_000007.13:g.107372335T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.370C=0.630
1000GenomesAmericanSub694T=0.240C=0.760
1000GenomesEast AsianSub1008T=0.017C=0.983
1000GenomesEuropeSub1006T=0.304C=0.696
1000GenomesGlobalStudy-wide5008T=0.223C=0.777
1000GenomesSouth AsianSub978T=0.140C=0.860
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.296C=0.704
The Genome Aggregation DatabaseAfricanSub8712T=0.373C=0.627
The Genome Aggregation DatabaseAmericanSub838T=0.180C=0.820
The Genome Aggregation DatabaseEast AsianSub1620T=0.011C=0.989
The Genome Aggregation DatabaseEuropeSub18474T=0.277C=0.722
The Genome Aggregation DatabaseGlobalStudy-wide29946T=0.288C=0.711
The Genome Aggregation DatabaseOtherSub302T=0.300C=0.700
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.312C=0.687
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.297C=0.703
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs109535456.55E-05alcohol consumption23743675

eQTL of rs10953545 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10953545 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr7107333486107333578E067-38757
chr7107333824107334105E067-38230
chr7107334175107334517E067-37818
chr7107334625107335182E067-37153
chr7107335233107335327E067-37008
chr7107383023107383099E06710688
chr7107386669107386772E06714334
chr7107387624107387709E06715289
chr7107387798107387880E06715463
chr7107333486107333578E068-38757
chr7107333824107334105E068-38230
chr7107334175107334517E068-37818
chr7107334625107335182E068-37153
chr7107335233107335327E068-37008
chr7107341168107341256E068-31079
chr7107341276107341497E068-30838
chr7107382753107382818E06810418
chr7107386669107386772E06814334
chr7107387624107387709E06815289
chr7107387798107387880E06815463
chr7107387932107387978E06815597
chr7107388350107388400E06816015
chr7107333486107333578E069-38757
chr7107333824107334105E069-38230
chr7107334175107334517E069-37818
chr7107334625107335182E069-37153
chr7107335233107335327E069-37008
chr7107335529107335618E069-36717
chr7107337294107337374E069-34961
chr7107337495107337545E069-34790
chr7107383023107383099E06910688
chr7107386669107386772E06914334
chr7107387624107387709E06915289
chr7107387798107387880E06915463
chr7107387932107387978E06915597
chr7107332948107333294E070-39041
chr7107333486107333578E070-38757
chr7107333824107334105E070-38230
chr7107334175107334517E070-37818
chr7107334625107335182E070-37153
chr7107335233107335327E070-37008
chr7107335529107335618E070-36717
chr7107335644107335829E070-36506
chr7107337495107337545E070-34790
chr7107337639107338679E070-33656
chr7107383023107383099E07010688
chr7107386669107386772E07014334
chr7107387798107387880E07015463
chr7107387932107387978E07015597
chr7107388350107388400E07016015
chr7107332129107332230E071-40105
chr7107332267107332442E071-39893
chr7107332948107333294E071-39041
chr7107333486107333578E071-38757
chr7107333824107334105E071-38230
chr7107335233107335327E071-37008
chr7107337495107337545E071-34790
chr7107337639107338679E071-33656
chr7107383023107383099E07110688
chr7107333824107334105E072-38230
chr7107334175107334517E072-37818
chr7107334625107335182E072-37153
chr7107337639107338679E072-33656
chr7107383023107383099E07210688
chr7107386669107386772E07214334
chr7107333824107334105E073-38230
chr7107334175107334517E073-37818
chr7107334625107335182E073-37153
chr7107335233107335327E073-37008
chr7107337639107338679E073-33656
chr7107333486107333578E074-38757
chr7107333824107334105E074-38230
chr7107334175107334517E074-37818
chr7107335233107335327E074-37008
chr7107333824107334105E081-38230
chr7107337639107338679E081-33656
chr7107338996107339076E081-33259
chr7107334175107334517E082-37818
chr7107334625107335182E082-37153
chr7107337294107337374E082-34961
chr7107337495107337545E082-34790
chr7107337639107338679E082-33656
chr7107386669107386772E08214334
chr7107387798107387880E08215463
chr7107387932107387978E08215597
chr7107388350107388400E08216015










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr7107383118107385525E06710783
chr7107383118107385525E06810783
chr7107383118107385525E06910783
chr7107383118107385525E07010783
chr7107383118107385525E07110783
chr7107383118107385525E07210783
chr7107383118107385525E07310783
chr7107383118107385525E07410783
chr7107383118107385525E08110783
chr7107383118107385525E08210783