rs10958045

Homo sapiens
T>C
SNX16 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0333 (9970/29870,GnomAD)
T==0344 (10016/29118,TOPMED)
T==0385 (1930/5008,1000G)
T==0333 (1282/3854,ALSPAC)
T==0321 (1189/3708,TWINSUK)
chr8:81810759 (GRCh38.p7) (8q21.13)
AD
GWASdb2
1   publication(s)
See rs on genome
94 Enhancers around
39 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.81810759T>C
GRCh37.p13 chr 8NC_000008.10:g.82722994T>C

Gene: SNX16, sorting nexin 16(minus strand)

Molecule type Change Amino acid[Codon] SO Term
SNX16 transcript variant 1NM_022133.3:c.N/AIntron Variant
SNX16 transcript variant 2NM_152836.2:c.N/AIntron Variant
SNX16 transcript variant 3NM_152837.2:c.N/AIntron Variant
SNX16 transcript variant X1XM_005251282.4:c.N/AIntron Variant
SNX16 transcript variant X2XM_005251283.2:c.N/AIntron Variant
SNX16 transcript variant X3XM_011517574.2:c.N/AIntron Variant
SNX16 transcript variant X3XR_001745572.1:n.N/AIntron Variant
SNX16 transcript variant X5XR_001745573.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.336C=0.664
1000GenomesAmericanSub694T=0.390C=0.610
1000GenomesEast AsianSub1008T=0.597C=0.403
1000GenomesEuropeSub1006T=0.327C=0.673
1000GenomesGlobalStudy-wide5008T=0.385C=0.615
1000GenomesSouth AsianSub978T=0.290C=0.710
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.333C=0.667
The Genome Aggregation DatabaseAfricanSub8692T=0.335C=0.665
The Genome Aggregation DatabaseAmericanSub834T=0.320C=0.680
The Genome Aggregation DatabaseEast AsianSub1602T=0.631C=0.369
The Genome Aggregation DatabaseEuropeSub18442T=0.307C=0.692
The Genome Aggregation DatabaseGlobalStudy-wide29870T=0.333C=0.666
The Genome Aggregation DatabaseOtherSub300T=0.370C=0.630
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.344C=0.656
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.321C=0.679
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs109580453.2E-05alcohol consumption23743675

eQTL of rs10958045 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10958045 in Fetal Brain

Probe ID Position Gene beta p-value
cg17211192chr8:82754475SNX160.06479748977329936.7363e-27
cg27398817chr8:82754497SNX160.03840175693116452.7176e-15
cg23324259chr8:82754387SNX160.01771319224007824.3004e-14

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr88272692182727044E0673927
chr88272708482727145E0674090
chr88272739782727713E0674403
chr88275141582751459E06728421
chr88275155182751632E06728557
chr88275169382751743E06728699
chr88275176982751905E06728775
chr88275192082751978E06728926
chr88275205182752101E06729057
chr88275213682752286E06729142
chr88275242482752500E06729430
chr88275252382752586E06729529
chr88274913582749745E06826141
chr88275040382750493E06827409
chr88275055782750622E06827563
chr88275073382750913E06827739
chr88275118682751259E06828192
chr88275141582751459E06828421
chr88275155182751632E06828557
chr88275169382751743E06828699
chr88275242482752500E06829430
chr88275252382752586E06829529
chr88275264882752702E06829654
chr88275205182752101E06929057
chr88275213682752286E06929142
chr88275242482752500E06929430
chr88275252382752586E06929529
chr88275264882752702E06929654
chr88270876682709232E070-13762
chr88270927582709325E070-13669
chr88270935482709440E070-13554
chr88273635982736422E07013365
chr88273760682737656E07014612
chr88273770482737783E07014710
chr88274913582749745E07026141
chr88272692182727044E0713927
chr88272739782727713E0714403
chr88275040382750493E07127409
chr88275055782750622E07127563
chr88275073382750913E07127739
chr88275176982751905E07128775
chr88275192082751978E07128926
chr88275205182752101E07129057
chr88275213682752286E07129142
chr88275242482752500E07129430
chr88275252382752586E07129529
chr88275264882752702E07129654
chr88277068982771569E07147695
chr88269268482693377E072-29617
chr88272629482726439E0723300
chr88272692182727044E0723927
chr88272708482727145E0724090
chr88272739782727713E0724403
chr88272739782727713E0734403
chr88272692182727044E0743927
chr88275040382750493E07427409
chr88275055782750622E07427563
chr88275073382750913E07427739
chr88275118682751259E07428192
chr88275141582751459E07428421
chr88275155182751632E07428557
chr88275169382751743E07428699
chr88275176982751905E07428775
chr88275192082751978E07428926
chr88275205182752101E07429057
chr88275213682752286E07429142
chr88275242482752500E07429430
chr88275252382752586E07429529
chr88275264882752702E07429654
chr88269268482693377E081-29617
chr88274894182748991E08125947
chr88275118682751259E08128192
chr88275141582751459E08128421
chr88275155182751632E08128557
chr88275169382751743E08128699
chr88275176982751905E08128775
chr88275192082751978E08128926
chr88275205182752101E08129057
chr88275213682752286E08129142
chr88275242482752500E08129430
chr88275252382752586E08129529
chr88275264882752702E08129654
chr88269939382699447E082-23547
chr88269957982699654E082-23340
chr88274913582749745E08226141
chr88274982582749873E08226831
chr88275155182751632E08228557
chr88275169382751743E08228699
chr88275176982751905E08228775
chr88275192082751978E08228926
chr88275205182752101E08229057
chr88275213682752286E08229142
chr88275242482752500E08229430
chr88275252382752586E08229529










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr88275290282753069E06729908
chr88275314082753307E06730146
chr88275349982753591E06730505
chr88275360282754599E06730608
chr88275349982753591E06830505
chr88275360282754599E06830608
chr88275461982755486E06831625
chr88275290282753069E06929908
chr88275314082753307E06930146
chr88275349982753591E06930505
chr88275360282754599E06930608
chr88275290282753069E07029908
chr88275314082753307E07030146
chr88275349982753591E07030505
chr88275360282754599E07030608
chr88275290282753069E07129908
chr88275314082753307E07130146
chr88275349982753591E07130505
chr88275360282754599E07130608
chr88275461982755486E07131625
chr88275290282753069E07229908
chr88275314082753307E07230146
chr88275349982753591E07230505
chr88275360282754599E07230608
chr88275290282753069E07329908
chr88275314082753307E07330146
chr88275349982753591E07330505
chr88275360282754599E07330608
chr88275461982755486E07331625
chr88275314082753307E07430146
chr88275349982753591E07430505
chr88275360282754599E07430608
chr88275461982755486E07431625
chr88275360282754599E08130608
chr88275290282753069E08229908
chr88275314082753307E08230146
chr88275349982753591E08230505
chr88275360282754599E08230608
chr88275461982755486E08231625