rs10963662

Homo sapiens
A>C
ADAMTSL1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0216 (6477/29944,GnomAD)
C=0243 (7103/29118,TOPMED)
C=0234 (1173/5008,1000G)
C=0157 (607/3854,ALSPAC)
C=0164 (608/3708,TWINSUK)
chr9:18601141 (GRCh38.p7) (9p22.1)
AD
GWASdb2
1   publication(s)
See rs on genome
68 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 9NC_000009.12:g.18601141A>C
GRCh37.p13 chr 9NC_000009.11:g.18601139A>C

Gene: ADAMTSL1, ADAMTS like 1(plus strand)

Molecule type Change Amino acid[Codon] SO Term
ADAMTSL1 transcript variant 4NM_001040272.5:c.N/AIntron Variant
ADAMTSL1 transcript variant 2NM_052866.4:c.N/AIntron Variant
ADAMTSL1 transcript variant X1XM_011518063.2:c.N/AIntron Variant
ADAMTSL1 transcript variant X3XM_011518064.2:c.N/AIntron Variant
ADAMTSL1 transcript variant X2XM_017015310.1:c.N/AIntron Variant
ADAMTSL1 transcript variant X4XM_017015311.1:c.N/AIntron Variant
ADAMTSL1 transcript variant X5XM_017015312.1:c.N/AIntron Variant
ADAMTSL1 transcript variant X6XM_017015313.1:c.N/AIntron Variant
ADAMTSL1 transcript variant X7XM_017015314.1:c.N/AIntron Variant
ADAMTSL1 transcript variant X8XM_011518067.1:c.N/AGenic Upstream Transcript Variant
ADAMTSL1 transcript variant X9XM_011518068.2:c.N/AGenic Upstream Transcript Variant
ADAMTSL1 transcript variant X10XM_011518070.2:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.625C=0.375
1000GenomesAmericanSub694A=0.820C=0.180
1000GenomesEast AsianSub1008A=0.764C=0.236
1000GenomesEuropeSub1006A=0.835C=0.165
1000GenomesGlobalStudy-wide5008A=0.766C=0.234
1000GenomesSouth AsianSub978A=0.850C=0.150
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.843C=0.157
The Genome Aggregation DatabaseAfricanSub8704A=0.671C=0.329
The Genome Aggregation DatabaseAmericanSub838A=0.830C=0.170
The Genome Aggregation DatabaseEast AsianSub1606A=0.823C=0.177
The Genome Aggregation DatabaseEuropeSub18494A=0.831C=0.168
The Genome Aggregation DatabaseGlobalStudy-wide29944A=0.783C=0.216
The Genome Aggregation DatabaseOtherSub302A=0.780C=0.220
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.756C=0.243
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.836C=0.164
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs109636620.000269alcohol dependence20201924

eQTL of rs10963662 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10963662 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr91860485118605020E0673712
chr91860503018605620E0673891
chr91860567218605722E0674533
chr91860576118606577E0674622
chr91860485118605020E0683712
chr91860503018605620E0683891
chr91860567218605722E0684533
chr91860576118606577E0684622
chr91860663918607204E0685500
chr91863081418630854E06829675
chr91863199918632095E06830860
chr91863239018632548E06831251
chr91863280818633316E06831669
chr91860485118605020E0693712
chr91860503018605620E0693891
chr91860567218605722E0694533
chr91860576118606577E0694622
chr91860663918607204E0695500
chr91860485118605020E0703712
chr91860503018605620E0703891
chr91860567218605722E0704533
chr91860576118606577E0704622
chr91860663918607204E0705500
chr91861097618611617E0709837
chr91861166518611817E07010526
chr91861188918611943E07010750
chr91860485118605020E0713712
chr91860503018605620E0713891
chr91860567218605722E0714533
chr91860576118606577E0714622
chr91860663918607204E0715500
chr91860850918608588E0717370
chr91860859518608651E0717456
chr91861067718610969E0719538
chr91861097618611617E0719837
chr91861166518611817E07110526
chr91861188918611943E07110750
chr91861457918615010E07113440
chr91860485118605020E0723712
chr91860503018605620E0723891
chr91860567218605722E0724533
chr91860576118606577E0724622
chr91860663918607204E0725500
chr91860737618607444E0726237
chr91861097618611617E0729837
chr91860485118605020E0733712
chr91860503018605620E0733891
chr91860567218605722E0734533
chr91860576118606577E0734622
chr91860485118605020E0743712
chr91860503018605620E0743891
chr91860576118606577E0744622
chr91860663918607204E0745500
chr91860850918608588E0747370
chr91860859518608651E0747456
chr91861067718610969E0749538
chr91861097618611617E0749837
chr91861166518611817E07410526
chr91861188918611943E07410750
chr91863280818633316E07431669
chr91860485118605020E0813712
chr91861166518611817E08110526
chr91861188918611943E08110750
chr91860503018605620E0823891
chr91860567218605722E0824533
chr91860576118606577E0824622
chr91861097618611617E0829837
chr91861166518611817E08210526