rs10985760

Homo sapiens
T>C / T>G
OR1L6 : Missense Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0136 (12640/92812,ExAC)
T==0134 (3918/29118,TOPMED)
T==0108 (2667/24534,GnomAD)
T==0118 (592/5008,1000G)
chr9:122750491 (GRCh38.p7) (9q33.2)
ND
GWASdb2
1   publication(s)
See rs on genome
11 Enhancers around
6 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 9NC_000009.12:g.122750491T>C
GRCh38.p7 chr 9NC_000009.12:g.122750491T>G
GRCh37.p13 chr 9NC_000009.11:g.125512770T>C
GRCh37.p13 chr 9NC_000009.11:g.125512770T>G
OR1L6 RefSeqGeneNG_034003.1:g.5644T>C
OR1L6 RefSeqGeneNG_034003.1:g.5644T>G

Gene: OR1L6, olfactory receptor family 1 subfamily L member 6(plus strand)

Molecule type Change Amino acid[Codon] SO Term
OR1L6 transcriptNM_001004453.2:c....NM_001004453.2:c.644T>CI [ATC]> T [ACC]Coding Sequence Variant
olfactory receptor 1L6NP_001004453.2:p....NP_001004453.2:p.Ile215ThrI [Ile]> T [Thr]Missense Variant
OR1L6 transcriptNM_001004453.2:c....NM_001004453.2:c.644T>GI [ATC]> S [AGC]Coding Sequence Variant
olfactory receptor 1L6NP_001004453.2:p....NP_001004453.2:p.Ile215SerI [Ile]> S [Ser]Missense Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.346C=0.654
1000GenomesAmericanSub694T=0.040C=0.960
1000GenomesEast AsianSub1008T=0.001C=0.999
1000GenomesEuropeSub1006T=0.061C=0.939
1000GenomesGlobalStudy-wide5008T=0.118C=0.882
1000GenomesSouth AsianSub978T=0.040C=0.960
The Exome Aggregation ConsortiumAmericanSub17726T=0.265C=0.734
The Exome Aggregation ConsortiumAsianSub16200T=0.090C=0.909
The Exome Aggregation ConsortiumEuropeSub58210T=0.109C=0.890
The Exome Aggregation ConsortiumGlobalStudy-wide92812T=0.136C=0.863
The Exome Aggregation ConsortiumOtherSub676T=0.140C=0.860
The Genome Aggregation DatabaseAfricanSub7178T=0.258C=0.742
The Genome Aggregation DatabaseAmericanSub722T=0.030C=0.970
The Genome Aggregation DatabaseEast AsianSub1308T=0.003C=0.997
The Genome Aggregation DatabaseEuropeSub15116T=0.051C=0.948
The Genome Aggregation DatabaseGlobalStudy-wide24534T=0.108C=0.891
The Genome Aggregation DatabaseOtherSub210T=0.050C=0.950
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.134C=0.865
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet

P-Value

SNP ID p-value Traits Study
rs109857608.79E-07alcohol and nictotine co-dependence20158304

eQTL of rs10985760 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10985760 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr932197783219871E06843401
chr932199123219996E06843535
chr931763883176447E07011
chr931768623176946E070485
chr932185033218557E07042126
chr932235153223594E07047138
chr932238263223886E07047449
chr932239053224136E07047528
chr932245723224657E07048195
chr932250083225269E07048631
chr932253473225397E07048970


Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr931805453182169E0674168
chr931805453182169E0684168
chr931805453182169E0694168
chr931805453182169E0724168
chr931805453182169E0734168
chr931805453182169E0744168