rs10995853

Homo sapiens
C>G
LOC105378334 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0034 (1018/29956,GnomAD)
G=0030 (879/29118,TOPMED)
G=0018 (89/5008,1000G)
G=0060 (232/3854,ALSPAC)
G=0054 (201/3708,TWINSUK)
chr10:64259979 (GRCh38.p7) (10q21.3)
OD
GWASCatalog
1   publication(s)
See rs on genome
15 Enhancers around
3 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.64259979C>G
GRCh37.p13 chr 10NC_000010.10:g.66019739C>G

Gene: LOC105378334, uncharacterized LOC105378334(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105378334 transcript variant X2XR_001747473.1:n.N/AIntron Variant
LOC105378334 transcript variant X3XR_001747474.1:n.N/AGenic Upstream Transcript Variant
LOC105378334 transcript variant X1XR_946016.2:n.N/AGenic Upstream Transcript Variant
LOC105378334 transcript variant X4XR_946017.2:n.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.999G=0.001
1000GenomesAmericanSub694C=0.970G=0.030
1000GenomesEast AsianSub1008C=0.993G=0.007
1000GenomesEuropeSub1006C=0.954G=0.046
1000GenomesGlobalStudy-wide5008C=0.982G=0.018
1000GenomesSouth AsianSub978C=0.990G=0.010
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.940G=0.060
The Genome Aggregation DatabaseAfricanSub8728C=0.991G=0.009
The Genome Aggregation DatabaseAmericanSub836C=0.990G=0.010
The Genome Aggregation DatabaseEast AsianSub1622C=0.998G=0.002
The Genome Aggregation DatabaseEuropeSub18468C=0.950G=0.049
The Genome Aggregation DatabaseGlobalStudy-wide29956C=0.966G=0.034
The Genome Aggregation DatabaseOtherSub302C=0.990G=0.010
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.969G=0.030
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.946G=0.054
PMID Title Author Journal
29478698Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans.Cheng ZBiol Psychiatry

P-Value

SNP ID p-value Traits Study
rs109958539E-07Opioid dependence29478698

eQTL of rs10995853 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10995853 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr106604620266046672E06726463
chr106604711866047168E06727379
chr106603685866036898E06817119
chr106604321466043892E06823475
chr106604822166048618E06828482
chr106604620266046672E06926463
chr106604711866047168E06927379
chr106604711866047168E07127379
chr106604822166048618E07128482
chr106604620266046672E07226463
chr106604711866047168E07227379
chr106604822166048618E07328482
chr106604321466043892E07423475
chr106604620266046672E07426463
chr106604822166048618E07428482







Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr106603731766037665E06817578
chr106603731766037665E07117578
chr106603731766037665E07217578