rs10997651

Homo sapiens
A>C
CTNNA3 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0180 (5380/29878,GnomAD)
C=0209 (6090/29118,TOPMED)
C=0283 (1417/5008,1000G)
C=0079 (304/3854,ALSPAC)
C=0080 (295/3708,TWINSUK)
chr10:67462712 (GRCh38.p7) (10q21.3)
AD
GWASdb2
1   publication(s)
See rs on genome
39 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.67462712A>C
GRCh37.p13 chr 10NC_000010.10:g.69222470A>C
CTNNA3 RefSeqGeneNG_034072.1:g.238480T>G

Gene: CTNNA3, catenin alpha 3(minus strand)

Molecule type Change Amino acid[Codon] SO Term
CTNNA3 transcript variant 2NM_001127384.2:c.N/AIntron Variant
CTNNA3 transcript variant 3NM_001291133.1:c.N/AIntron Variant
CTNNA3 transcript variant 1NM_013266.3:c.N/AIntron Variant
CTNNA3 transcript variant X1XM_017016151.1:c.N/AIntron Variant
CTNNA3 transcript variant X2XM_017016152.1:c.N/AIntron Variant
CTNNA3 transcript variant X3XM_017016153.1:c.N/AIntron Variant
CTNNA3 transcript variant X8XM_017016158.1:c.N/AIntron Variant
CTNNA3 transcript variant X4XM_017016154.1:c.N/AGenic Upstream Transcript Variant
CTNNA3 transcript variant X5XM_017016155.1:c.N/AGenic Upstream Transcript Variant
CTNNA3 transcript variant X6XM_017016156.1:c.N/AGenic Upstream Transcript Variant
CTNNA3 transcript variant X7XM_017016157.1:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.595C=0.405
1000GenomesAmericanSub694A=0.840C=0.160
1000GenomesEast AsianSub1008A=0.624C=0.376
1000GenomesEuropeSub1006A=0.918C=0.082
1000GenomesGlobalStudy-wide5008A=0.717C=0.283
1000GenomesSouth AsianSub978A=0.680C=0.320
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.921C=0.079
The Genome Aggregation DatabaseAfricanSub8680A=0.644C=0.356
The Genome Aggregation DatabaseAmericanSub832A=0.850C=0.150
The Genome Aggregation DatabaseEast AsianSub1594A=0.669C=0.331
The Genome Aggregation DatabaseEuropeSub18470A=0.912C=0.087
The Genome Aggregation DatabaseGlobalStudy-wide29878A=0.819C=0.180
The Genome Aggregation DatabaseOtherSub302A=0.890C=0.110
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.790C=0.209
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.920C=0.080
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs109976510.000208alcohol dependence20201924

eQTL of rs10997651 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10997651 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr106923206269232267E0679592
chr106919862969198679E068-23791
chr106919872869198998E068-23472
chr106923206269232267E0689592
chr106918997069190020E069-32450
chr106919803969198303E069-24167
chr106919843769198593E069-23877
chr106919862969198679E069-23791
chr106919872869198998E069-23472
chr106918306969183119E071-39351
chr106918997069190020E071-32450
chr106919803969198303E071-24167
chr106919843769198593E071-23877
chr106919872869198998E071-23472
chr106919907869199138E071-23332
chr106919915569199208E071-23262
chr106919953869199645E071-22825
chr106923206269232267E0719592
chr106919843769198593E072-23877
chr106919862969198679E072-23791
chr106919872869198998E072-23472
chr106919907869199138E072-23332
chr106919915569199208E072-23262
chr106918306969183119E074-39351
chr106918997069190020E074-32450
chr106919803969198303E074-24167
chr106919843769198593E074-23877
chr106919862969198679E074-23791
chr106919872869198998E074-23472
chr106919907869199138E074-23332
chr106919915569199208E074-23262
chr106923189469231988E0749424
chr106923206269232267E0749592
chr106921414169214258E081-8212
chr106921429769214359E081-8111
chr106921487669214984E081-7486
chr106921501369215057E081-7413
chr106921532069215370E081-7100
chr106921539869215448E081-7022