rs11018077

Homo sapiens
G>A
DOCK1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0302 (9005/29792,GnomAD)
A=0336 (9791/29118,TOPMED)
A=0264 (1322/5008,1000G)
A=0272 (1050/3854,ALSPAC)
A=0260 (965/3708,TWINSUK)
chr10:127429224 (GRCh38.p7) (10q26.2)
AD
GWASdb2
1   publication(s)
See rs on genome
126 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.127429224G>A
GRCh37.p13 chr 10NC_000010.10:g.129227488G>A
DOCK1 RefSeqGeneNG_033919.2:g.528771G>A

Gene: DOCK1, dedicator of cytokinesis 1(plus strand)

Molecule type Change Amino acid[Codon] SO Term
DOCK1 transcript variant 1NM_001290223.1:c.N/AIntron Variant
DOCK1 transcript variant 2NM_001380.4:c.N/AIntron Variant
DOCK1 transcript variant X1XM_011539422.2:c.N/AIntron Variant
DOCK1 transcript variant X3XM_011539424.1:c.N/AIntron Variant
DOCK1 transcript variant X2XM_017015813.1:c.N/AIntron Variant
DOCK1 transcript variant X6XM_017015816.1:c.N/AIntron Variant
DOCK1 transcript variant X4XM_017015814.1:c.N/AGenic Downstream Transcript Variant
DOCK1 transcript variant X5XM_017015815.1:c.N/AGenic Downstream Transcript Variant
DOCK1 transcript variant X7XM_017015817.1:c.N/AGenic Downstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.576A=0.424
1000GenomesAmericanSub694G=0.700A=0.300
1000GenomesEast AsianSub1008G=0.807A=0.193
1000GenomesEuropeSub1006G=0.760A=0.240
1000GenomesGlobalStudy-wide5008G=0.736A=0.264
1000GenomesSouth AsianSub978G=0.880A=0.120
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.728A=0.272
The Genome Aggregation DatabaseAfricanSub8660G=0.592A=0.408
The Genome Aggregation DatabaseAmericanSub832G=0.720A=0.280
The Genome Aggregation DatabaseEast AsianSub1614G=0.819A=0.181
The Genome Aggregation DatabaseEuropeSub18384G=0.734A=0.265
The Genome Aggregation DatabaseGlobalStudy-wide29792G=0.697A=0.302
The Genome Aggregation DatabaseOtherSub302G=0.790A=0.210
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.663A=0.336
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.740A=0.260
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs110180770.00076alcohol dependence20201924

eQTL of rs11018077 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs11018077 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr10129196385129196429E067-31059
chr10129196695129196897E067-30591
chr10129196977129197108E067-30380
chr10129221912129222044E067-5444
chr10129222081129222221E067-5267
chr10129222410129222477E067-5011
chr10129222516129222662E067-4826
chr10129261096129261187E06733608
chr10129261319129261386E06733831
chr10129191518129191774E068-35714
chr10129193582129193632E068-33856
chr10129193936129194153E068-33335
chr10129194390129194515E068-32973
chr10129194597129194666E068-32822
chr10129196137129196257E068-31231
chr10129196385129196429E068-31059
chr10129196695129196897E068-30591
chr10129196977129197108E068-30380
chr10129261096129261187E06833608
chr10129261319129261386E06833831
chr10129189862129189912E069-37576
chr10129189951129190009E069-37479
chr10129194390129194515E069-32973
chr10129194597129194666E069-32822
chr10129196385129196429E069-31059
chr10129196695129196897E069-30591
chr10129196977129197108E069-30380
chr10129197285129197380E069-30108
chr10129204347129204387E069-23101
chr10129204548129204603E069-22885
chr10129221765129221845E069-5643
chr10129221912129222044E069-5444
chr10129222081129222221E069-5267
chr10129222410129222477E069-5011
chr10129222516129222662E069-4826
chr10129222757129223647E069-3841
chr10129239384129239507E07011896
chr10129239636129239939E07012148
chr10129239995129240232E07012507
chr10129249451129249501E07021963
chr10129249967129250238E07022479
chr10129250936129250990E07023448
chr10129251000129251095E07023512
chr10129251145129251195E07023657
chr10129251269129251431E07023781
chr10129193936129194153E071-33335
chr10129194390129194515E071-32973
chr10129194597129194666E071-32822
chr10129194764129195012E071-32476
chr10129196385129196429E071-31059
chr10129196695129196897E071-30591
chr10129196977129197108E071-30380
chr10129197285129197380E071-30108
chr10129198051129198308E071-29180
chr10129204029129204079E071-23409
chr10129204347129204387E071-23101
chr10129204548129204603E071-22885
chr10129214454129215148E071-12340
chr10129215168129215266E071-12222
chr10129215283129215383E071-12105
chr10129215497129215541E071-11947
chr10129221509129221700E071-5788
chr10129221765129221845E071-5643
chr10129221912129222044E071-5444
chr10129222081129222221E071-5267
chr10129222410129222477E071-5011
chr10129222516129222662E071-4826
chr10129222757129223647E071-3841
chr10129193936129194153E072-33335
chr10129194390129194515E072-32973
chr10129194597129194666E072-32822
chr10129194764129195012E072-32476
chr10129196137129196257E072-31231
chr10129196385129196429E072-31059
chr10129196695129196897E072-30591
chr10129196977129197108E072-30380
chr10129204548129204603E072-22885
chr10129221509129221700E072-5788
chr10129221765129221845E072-5643
chr10129221912129222044E072-5444
chr10129222081129222221E072-5267
chr10129222410129222477E072-5011
chr10129222516129222662E072-4826
chr10129222757129223647E072-3841
chr10129196385129196429E073-31059
chr10129196695129196897E073-30591
chr10129222410129222477E073-5011
chr10129222516129222662E073-4826
chr10129222757129223647E073-3841
chr10129261096129261187E07333608
chr10129261319129261386E07333831
chr10129193936129194153E074-33335
chr10129194390129194515E074-32973
chr10129194597129194666E074-32822
chr10129194764129195012E074-32476
chr10129196027129196116E074-31372
chr10129196137129196257E074-31231
chr10129196385129196429E074-31059
chr10129196695129196897E074-30591
chr10129196977129197108E074-30380
chr10129197285129197380E074-30108
chr10129204029129204079E074-23409
chr10129204347129204387E074-23101
chr10129204548129204603E074-22885
chr10129221509129221700E074-5788
chr10129221765129221845E074-5643
chr10129221912129222044E074-5444
chr10129222081129222221E074-5267
chr10129222410129222477E074-5011
chr10129222516129222662E074-4826
chr10129222757129223647E074-3841
chr10129205261129205301E081-22187
chr10129206050129206110E081-21378
chr10129225784129225834E081-1654
chr10129226196129226265E081-1223
chr10129226286129226596E081-892
chr10129239048129239108E08111560
chr10129239384129239507E08111896
chr10129239636129239939E08112148
chr10129239995129240232E08112507
chr10129240332129240512E08112844
chr10129256223129256273E08128735
chr10129256364129256568E08128876
chr10129222757129223647E082-3841
chr10129256223129256273E08228735
chr10129256364129256568E08228876