rs11023186

Homo sapiens
G>A
RRAS2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0154 (4586/29688,GnomAD)
A=0128 (3736/29118,TOPMED)
A=0149 (746/5008,1000G)
A=0110 (425/3854,ALSPAC)
A=0111 (412/3708,TWINSUK)
chr11:14321215 (GRCh38.p7) (11p15.2)
AD
GWASdb2
1   publication(s)
See rs on genome
110 Enhancers around
31 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.14321215G>A
GRCh37.p13 chr 11 fix patch HG256_PATCHNW_003871075.1:g.379299G>A
RRAS2 RefSeqGeneNG_017058.1:g.48292C>T
GRCh37.p13 chr 11NC_000011.9:g.14342761G>A

Gene: RRAS2, related RAS viral (r-ras) oncogene homolog 2(minus strand)

Molecule type Change Amino acid[Codon] SO Term
RRAS2 transcript variant 2NM_001102669.2:c.N/AIntron Variant
RRAS2 transcript variant 3NM_001177314.1:c.N/AIntron Variant
RRAS2 transcript variant 4NM_001177315.1:c.N/AIntron Variant
RRAS2 transcript variant 1NM_012250.5:c.N/AIntron Variant
RRAS2 transcript variant X1XM_017017363.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.799A=0.201
1000GenomesAmericanSub694G=0.910A=0.090
1000GenomesEast AsianSub1008G=0.809A=0.191
1000GenomesEuropeSub1006G=0.875A=0.125
1000GenomesGlobalStudy-wide5008G=0.851A=0.149
1000GenomesSouth AsianSub978G=0.900A=0.100
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.890A=0.110
The Genome Aggregation DatabaseAfricanSub8658G=0.833A=0.167
The Genome Aggregation DatabaseAmericanSub812G=0.920A=0.080
The Genome Aggregation DatabaseEast AsianSub1620G=0.812A=0.188
The Genome Aggregation DatabaseEuropeSub18296G=0.850A=0.149
The Genome Aggregation DatabaseGlobalStudy-wide29688G=0.845A=0.154
The Genome Aggregation DatabaseOtherSub302G=0.870A=0.130
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.871A=0.128
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.889A=0.111
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs110231860.0000966alcoholismpha002891
rs110231860.0000966alcohol dependence20201924

eQTL of rs11023186 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs11023186 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr11350483351410E067-27889
chr11357716357804E067-21495
chr11357812357955E067-21344
chr11371159371508E067-7791
chr11373524373653E067-5646
chr11373706373842E067-5457
chr11373933374381E067-4918
chr11374494374544E067-4755
chr11335536337159E068-42140
chr11352587352772E068-26527
chr11352835354238E068-25061
chr11371159371508E068-7791
chr11371557371756E068-7543
chr11371764372056E068-7243
chr11373382373446E068-5853
chr11373524373653E068-5646
chr11373706373842E068-5457
chr11373933374381E068-4918
chr11334067334975E069-44324
chr11335536337159E069-42140
chr11350483351410E069-27889
chr11352587352772E069-26527
chr11352835354238E069-25061
chr11371159371508E069-7791
chr11371557371756E069-7543
chr11371764372056E069-7243
chr11372084372449E069-6850
chr11372467372517E069-6782
chr11372589372629E069-6670
chr11372705372755E069-6544
chr11372868372918E069-6381
chr11373092373155E069-6144
chr11373382373446E069-5853
chr11373524373653E069-5646
chr11373706373842E069-5457
chr11373933374381E069-4918
chr11375224375389E069-3910
chr11375416375564E069-3735
chr11405412405591E06926113
chr11387566387802E0708267
chr11387882387974E0708583
chr11388173388259E0708874
chr11335148335188E071-44111
chr11335250335303E071-43996
chr11335413335497E071-43802
chr11335536337159E071-42140
chr11337609337659E071-41640
chr11349879350005E071-29294
chr11350175350272E071-29027
chr11350483351410E071-27889
chr11352587352772E071-26527
chr11352835354238E071-25061
chr11371159371508E071-7791
chr11371557371756E071-7543
chr11371764372056E071-7243
chr11372084372449E071-6850
chr11373524373653E071-5646
chr11373706373842E071-5457
chr11335536337159E072-42140
chr11349623349683E072-29616
chr11349879350005E072-29294
chr11350175350272E072-29027
chr11352835354238E072-25061
chr11371159371508E072-7791
chr11371557371756E072-7543
chr11371764372056E072-7243
chr11372084372449E072-6850
chr11373382373446E072-5853
chr11373524373653E072-5646
chr11373706373842E072-5457
chr11375224375389E072-3910
chr11375416375564E072-3735
chr11405211405360E07225912
chr11405412405591E07226113
chr11335536337159E073-42140
chr11342185342386E073-36913
chr11342390342745E073-36554
chr11352444352550E073-26749
chr11352587352772E073-26527
chr11352835354238E073-25061
chr11371557371756E073-7543
chr11371764372056E073-7243
chr11372084372449E073-6850
chr11372467372517E073-6782
chr11372589372629E073-6670
chr11372705372755E073-6544
chr11372868372918E073-6381
chr11373092373155E073-6144
chr11373382373446E073-5853
chr11373524373653E073-5646
chr11373706373842E073-5457
chr11373933374381E073-4918
chr11374494374544E073-4755
chr11375416375564E073-3735
chr11375787376003E073-3296
chr11335536337159E074-42140
chr11350483351410E074-27889
chr11352444352550E074-26749
chr11352587352772E074-26527
chr11352835354238E074-25061
chr11373706373842E074-5457
chr11373933374381E074-4918
chr11374494374544E074-4755
chr11371159371508E081-7791
chr11371557371756E081-7543
chr11371764372056E081-7243
chr11372084372449E081-6850
chr11372084372449E082-6850
chr11372467372517E082-6782
chr11372589372629E082-6670










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr11368932369004E067-10295
chr11370057370956E067-8343
chr11368932369004E068-10295
chr11369769370052E068-9247
chr11370057370956E068-8343
chr11414368418062E06835069
chr11368932369004E069-10295
chr11369769370052E069-9247
chr11370057370956E069-8343
chr11368932369004E070-10295
chr11369056369084E070-10215
chr11369098369261E070-10038
chr11369300369768E070-9531
chr11369769370052E070-9247
chr11370057370956E070-8343
chr11370057370956E071-8343
chr11368932369004E072-10295
chr11369769370052E072-9247
chr11370057370956E072-8343
chr11368932369004E073-10295
chr11369769370052E073-9247
chr11370057370956E073-8343
chr11368932369004E074-10295
chr11370057370956E074-8343
chr11368932369004E081-10295
chr11368932369004E082-10295
chr11369056369084E082-10215
chr11369098369261E082-10038
chr11369300369768E082-9531
chr11369769370052E082-9247
chr11370057370956E082-8343