rs11025421

Homo sapiens
C>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0056 (1693/29936,GnomAD)
A=0064 (1890/29118,TOPMED)
A=0056 (279/5008,1000G)
A=0059 (227/3854,ALSPAC)
A=0059 (217/3708,TWINSUK)
chr11:20177732 (GRCh38.p7) (11p15.1)
AD
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
9 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.20177732C>A
GRCh37.p13 chr 11NC_000011.9:g.20199278C>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.947A=0.053
1000GenomesAmericanSub694C=0.940A=0.060
1000GenomesEast AsianSub1008C=0.897A=0.103
1000GenomesEuropeSub1006C=0.958A=0.042
1000GenomesGlobalStudy-wide5008C=0.944A=0.056
1000GenomesSouth AsianSub978C=0.980A=0.020
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.941A=0.059
The Genome Aggregation DatabaseAfricanSub8726C=0.946A=0.054
The Genome Aggregation DatabaseAmericanSub838C=0.930A=0.070
The Genome Aggregation DatabaseEast AsianSub1620C=0.907A=0.093
The Genome Aggregation DatabaseEuropeSub18450C=0.946A=0.053
The Genome Aggregation DatabaseGlobalStudy-wide29936C=0.943A=0.056
The Genome Aggregation DatabaseOtherSub302C=0.960A=0.040
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.935A=0.064
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.941A=0.059
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs110254210.000771alcohol dependence24277619

eQTL of rs11025421 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs11025421 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr112015455120154678E069-44600
chr112019837220198496E070-782
chr112019852620198944E070-334


Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr112015325620154400E067-44878
chr112015325620154400E068-44878
chr112015325620154400E069-44878
chr112015325620154400E071-44878
chr112015325620154400E072-44878
chr112015325620154400E073-44878
chr112015325620154400E074-44878
chr112015325620154400E081-44878
chr112015325620154400E082-44878