rs1107573

Homo sapiens
C>T
LOC105376622 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0058 (1757/29986,GnomAD)
T=0072 (2118/29118,TOPMED)
T=0049 (246/5008,1000G)
T=0039 (151/3854,ALSPAC)
T=0039 (145/3708,TWINSUK)
chr11:34434661 (GRCh38.p7) (11p13)
AD
GWASdb2
2   publication(s)
See rs on genome
15 Enhancers around
16 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.34434661C>T
GRCh37.p13 chr 11NC_000011.9:g.34456208C>T
CAT RefSeqGeneNG_013339.1:g.737C>T

Gene: LOC105376622, uncharacterized LOC105376622(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105376622 transcriptXR_931180.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.878T=0.122
1000GenomesAmericanSub694C=0.970T=0.030
1000GenomesEast AsianSub1008C=1.000T=0.000
1000GenomesEuropeSub1006C=0.956T=0.044
1000GenomesGlobalStudy-wide5008C=0.951T=0.049
1000GenomesSouth AsianSub978C=0.980T=0.020
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.961T=0.039
The Genome Aggregation DatabaseAfricanSub8718C=0.891T=0.109
The Genome Aggregation DatabaseAmericanSub838C=0.970T=0.030
The Genome Aggregation DatabaseEast AsianSub1622C=1.000T=0.000
The Genome Aggregation DatabaseEuropeSub18506C=0.959T=0.040
The Genome Aggregation DatabaseGlobalStudy-wide29986C=0.941T=0.058
The Genome Aggregation DatabaseOtherSub302C=0.910T=0.090
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.927T=0.072
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.961T=0.039
PMID Title Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.Wang KSJ Psychiatr Res
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs11075730.000066alcohol dependence21703634
rs11075730.00039alcohol dependence20201924

eQTL of rs1107573 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1107573 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr113446431934464369E0688111
chr113447611334476163E06819905
chr113447632034476483E06820112
chr113447658534477021E06820377
chr113442882134429256E069-26952
chr113442933034429448E069-26760
chr113446979334469875E06913585
chr113446994634470013E06913738
chr113442933034429448E071-26760
chr113442882134429256E072-26952
chr113442933034429448E072-26760
chr113446431934464369E0738111
chr113442882134429256E074-26952
chr113442933034429448E074-26760
chr113446252734462567E0826319







Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr113445971234461758E0673504
chr113445957034459620E0683362
chr113445971234461758E0683504
chr113445957034459620E0693362
chr113445971234461758E0693504
chr113445957034459620E0703362
chr113445971234461758E0703504
chr113445971234461758E0713504
chr113445957034459620E0723362
chr113445971234461758E0723504
chr113445957034459620E0733362
chr113445971234461758E0733504
chr113445971234461758E0743504
chr113445971234461758E0813504
chr113445957034459620E0823362
chr113445971234461758E0823504