rs1108402

Homo sapiens
C>G / C>T
WIPF3 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0104 (3114/29866,GnomAD)
T=0109 (3189/29118,TOPMED)
T=0089 (444/5008,1000G)
T=0128 (492/3854,ALSPAC)
T=0129 (480/3708,TWINSUK)
chr7:29877002 (GRCh38.p7) (7p14.3)
ND
GWASdb2
1   publication(s)
See rs on genome

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.29877002C>G
GRCh38.p7 chr 7NC_000007.14:g.29877002C>T
GRCh37.p13 chr 7NC_000007.13:g.29916618C>G
GRCh37.p13 chr 7NC_000007.13:g.29916618C>T

Gene: WIPF3, WAS/WASL interacting protein family member 3(plus strand)

Molecule type Change Amino acid[Codon] SO Term
WIPF3 transcriptNM_001080529.2:c.N/AIntron Variant
WIPF3 transcript variant X1XM_017012522.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.937T=0.063
1000GenomesAmericanSub694C=0.900T=0.10,
1000GenomesEast AsianSub1008C=0.979T=0.020
1000GenomesEuropeSub1006C=0.858T=0.142
1000GenomesGlobalStudy-wide5008C=0.911T=0.089
1000GenomesSouth AsianSub978C=0.870T=0.13,
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.872T=0.128
The Genome Aggregation DatabaseAfricanSub8698C=0.927T=0.073
The Genome Aggregation DatabaseAmericanSub838C=0.900T=0.100
The Genome Aggregation DatabaseEast AsianSub1616C=0.984T=0.016
The Genome Aggregation DatabaseEuropeSub18412C=0.874T=0.125
The Genome Aggregation DatabaseGlobalStudy-wide29866C=0.895T=0.104
The Genome Aggregation DatabaseOtherSub302C=0.810T=0.190
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.890T=0.109
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.871T=0.129
PMID Title Author Journal
22488850Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.Zuo LAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs11084021.2E-05alcohol and nictotine co-dependence22488850

eQTL of rs1108402 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1108402 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr73702129337021434E067-42914
chr73703253937032645E067-31703
chr73703282937032873E067-31475
chr73703416437034250E067-30098
chr73703430637034607E067-29741
chr73703723137037281E067-27067
chr73703740337037459E067-26889
chr73703751537037626E067-26722
chr73703908637039136E067-25212
chr73704605037046100E067-18248
chr73704610237046156E067-18192
chr73704646637046661E067-17687
chr73704672637046841E067-17507
chr73704699737047247E067-17101
chr73704725037047371E067-16977
chr73704746537047588E067-16760
chr73704772237047926E067-16422
chr73704851137048607E067-15741
chr73704883737048937E067-15411
chr73704903837049146E067-15202
chr73704971437049764E067-14584
chr73704990837049958E067-14390
chr73705268037052730E067-11618
chr73705278237052868E067-11480
chr73705304337053112E067-11236
chr73705317237053222E067-11126
chr73705326637053770E067-10578
chr73705378437053834E067-10514
chr73705433037054387E067-9961
chr73705439137054441E067-9907
chr73705447937054573E067-9775
chr73706623437066860E0671886
chr73707069837070929E0676350
chr73707099537072426E0676647
chr73707247937072839E0678131
chr73707304137073091E0678693
chr73707312537073223E0678777
chr73708260037082677E06718252
chr73708273137082781E06718383
chr73708553537085605E06721187
chr73708572337085773E06721375
chr73708615437086224E06721806
chr73708628237086332E06721934
chr73708633537086553E06721987
chr73708680137087213E06722453
chr73709222537092740E06727877
chr73709277337092881E06728425
chr73709293137093129E06728583
chr73709313637093217E06728788
chr73710201137102118E06737663
chr73710222437102430E06737876
chr73702035537020587E068-43761
chr73702061737020667E068-43681
chr73702116337021213E068-43135
chr73703416437034250E068-30098
chr73703615737036237E068-28111
chr73703628637036336E068-28012
chr73704605037046100E068-18248
chr73704610237046156E068-18192
chr73704646637046661E068-17687
chr73704672637046841E068-17507
chr73704699737047247E068-17101
chr73704903837049146E068-15202
chr73705007937050129E068-14219
chr73705527037055339E068-9009
chr73705542237055545E068-8803
chr73705558437055638E068-8710
chr73705575437055973E068-8375
chr73705601137056087E068-8261
chr73706623437066860E0681886
chr73706691537067021E0682567
chr73707069837070929E0686350
chr73707099537072426E0686647
chr73707247937072839E0688131
chr73707304137073091E0688693
chr73707312537073223E0688777
chr73707544737075575E06811099
chr73708553537085605E06821187
chr73708572337085773E06821375
chr73708615437086224E06821806
chr73708628237086332E06821934
chr73708633537086553E06821987
chr73708680137087213E06822453
chr73710222437102430E06837876
chr73710254937102659E06838201
chr73711414837114209E06849800
chr73702000837020099E069-44249
chr73702035537020587E069-43761
chr73702604637027177E069-37171
chr73703208437032215E069-32133
chr73703253937032645E069-31703
chr73703282937032873E069-31475
chr73703416437034250E069-30098
chr73703430637034607E069-29741
chr73703628637036336E069-28012
chr73703723137037281E069-27067
chr73703740337037459E069-26889
chr73703751537037626E069-26722
chr73703908637039136E069-25212
chr73703932037040481E069-23867
chr73704536737045792E069-18556
chr73704605037046100E069-18248
chr73704610237046156E069-18192
chr73704646637046661E069-17687
chr73704672637046841E069-17507
chr73704699737047247E069-17101
chr73704725037047371E069-16977
chr73704746537047588E069-16760
chr73704772237047926E069-16422
chr73704851137048607E069-15741
chr73704883737048937E069-15411
chr73704903837049146E069-15202
chr73704971437049764E069-14584
chr73704990837049958E069-14390
chr73705007937050129E069-14219
chr73705268037052730E069-11618
chr73705278237052868E069-11480
chr73705304337053112E069-11236
chr73705317237053222E069-11126
chr73705326637053770E069-10578
chr73705378437053834E069-10514
chr73705433037054387E069-9961
chr73705439137054441E069-9907
chr73705447937054573E069-9775
chr73707099537072426E0696647
chr73707247937072839E0698131
chr73707304137073091E0698693
chr73707312537073223E0698777
chr73708093637081444E06916588
chr73708153737081591E06917189
chr73708170437081997E06917356
chr73708553537085605E06921187
chr73708572337085773E06921375
chr73708615437086224E06921806
chr73708628237086332E06921934
chr73708633537086553E06921987
chr73708680137087213E06922453
chr73709222537092740E06927877
chr73709277337092881E06928425
chr73709293137093129E06928583
chr73709313637093217E06928788
chr73710969737109939E06945349
chr73702720137027256E070-37092
chr73702726237027327E070-37021
chr73704536737045792E070-18556
chr73704605037046100E070-18248
chr73704610237046156E070-18192
chr73704646637046661E070-17687
chr73704672637046841E070-17507
chr73704699737047247E070-17101
chr73704725037047371E070-16977
chr73704746537047588E070-16760
chr73704772237047926E070-16422
chr73704851137048607E070-15741
chr73704883737048937E070-15411
chr73704903837049146E070-15202
chr73704971437049764E070-14584
chr73704990837049958E070-14390
chr73705007937050129E070-14219
chr73705326637053770E070-10578
chr73705378437053834E070-10514
chr73709425337095092E07029905
chr73709512537095180E07030777
chr73709582037095940E07031472
chr73709621237096282E07031864
chr73709715437097204E07032806
chr73710149437101603E07037146
chr73710161637101789E07037268
chr73710179037101950E07037442
chr73710201137102118E07037663
chr73710222437102430E07037876
chr73710254937102659E07038201
chr73710272437102776E07038376
chr73701945037019956E071-44392
chr73702000837020099E071-44249
chr73702035537020587E071-43761
chr73702061737020667E071-43681
chr73702116337021213E071-43135
chr73702129337021434E071-42914
chr73703253937032645E071-31703
chr73703416437034250E071-30098
chr73703551337035606E071-28742
chr73703578937035993E071-28355
chr73703615737036237E071-28111
chr73703628637036336E071-28012
chr73703671937036775E071-27573
chr73703723137037281E071-27067
chr73703740337037459E071-26889
chr73703751537037626E071-26722
chr73703932037040481E071-23867
chr73704536737045792E071-18556
chr73704605037046100E071-18248
chr73704610237046156E071-18192
chr73704646637046661E071-17687
chr73704672637046841E071-17507
chr73704699737047247E071-17101
chr73704725037047371E071-16977
chr73704746537047588E071-16760
chr73704772237047926E071-16422
chr73704851137048607E071-15741
chr73704883737048937E071-15411
chr73704903837049146E071-15202
chr73704971437049764E071-14584
chr73704990837049958E071-14390
chr73705007937050129E071-14219
chr73705190037051976E071-12372
chr73705203237052072E071-12276
chr73705268037052730E071-11618
chr73705278237052868E071-11480
chr73705304337053112E071-11236
chr73705317237053222E071-11126
chr73705326637053770E071-10578
chr73705378437053834E071-10514
chr73705601137056087E071-8261
chr73705613637056646E071-7702
chr73705675037056790E071-7558
chr73706029337060629E071-3719
chr73706070037060850E071-3498
chr73707069837070929E0716350
chr73707099537072426E0716647
chr73707247937072839E0718131
chr73707304137073091E0718693
chr73707312537073223E0718777
chr73708514637085275E07120798
chr73708553537085605E07121187
chr73708572337085773E07121375
chr73708615437086224E07121806
chr73708628237086332E07121934
chr73708633537086553E07121987
chr73708680137087213E07122453
chr73708722337087434E07122875
chr73708773037087878E07123382
chr73708795637088056E07123608
chr73708806637088138E07123718
chr73708822337088339E07123875
chr73708836837088418E07124020
chr73709222537092740E07127877
chr73709277337092881E07128425
chr73709293137093129E07128583
chr73709313637093217E07128788
chr73709355437093604E07129206
chr73709367637093754E07129328
chr73709391637094112E07129568
chr73709425337095092E07129905
chr73709512537095180E07130777
chr73709520637095256E07130858
chr73709531037095370E07130962
chr73710222437102430E07137876
chr73710254937102659E07138201
chr73710272437102776E07138376
chr73710531137105946E07140963
chr73711053737110577E07146189
chr73711403237114109E07149684
chr73711414837114209E07149800
chr73702720137027256E072-37092
chr73702726237027327E072-37021
chr73703253937032645E072-31703
chr73703282937032873E072-31475
chr73703416437034250E072-30098
chr73703430637034607E072-29741
chr73703932037040481E072-23867
chr73704536737045792E072-18556
chr73704605037046100E072-18248
chr73704610237046156E072-18192
chr73704646637046661E072-17687
chr73704672637046841E072-17507
chr73704699737047247E072-17101
chr73704725037047371E072-16977
chr73704746537047588E072-16760
chr73704772237047926E072-16422
chr73704971437049764E072-14584
chr73704990837049958E072-14390
chr73705007937050129E072-14219
chr73706623437066860E0721886
chr73706691537067021E0722567
chr73707099537072426E0726647
chr73707247937072839E0728131
chr73707304137073091E0728693
chr73707312537073223E0728777
chr73707341937073528E0729071
chr73707361337073663E0729265
chr73707379337073843E0729445
chr73708260037082677E07218252
chr73708273137082781E07218383
chr73708410337084183E07219755
chr73708514637085275E07220798
chr73708553537085605E07221187
chr73708572337085773E07221375
chr73709222537092740E07227877
chr73709277337092881E07228425
chr73709293137093129E07228583
chr73709313637093217E07228788
chr73711053737110577E07246189
chr73701906037019104E073-45244
chr73701924137019319E073-45029
chr73701933737019387E073-44961
chr73701945037019956E073-44392
chr73702604637027177E073-37171
chr73703416437034250E073-30098
chr73703615737036237E073-28111
chr73703628637036336E073-28012
chr73703671937036775E073-27573
chr73703908637039136E073-25212
chr73703932037040481E073-23867
chr73707057037070627E0736222
chr73707069837070929E0736350
chr73707099537072426E0736647
chr73707247937072839E0738131
chr73708553537085605E07321187
chr73708572337085773E07321375
chr73708615437086224E07321806
chr73708628237086332E07321934
chr73708633537086553E07321987
chr73709293137093129E07328583
chr73710969737109939E07345349
chr73702000837020099E074-44249
chr73702035537020587E074-43761
chr73702116337021213E074-43135
chr73702129337021434E074-42914
chr73702604637027177E074-37171
chr73703551337035606E074-28742
chr73703578937035993E074-28355
chr73703615737036237E074-28111
chr73703628637036336E074-28012
chr73703671937036775E074-27573
chr73703723137037281E074-27067
chr73703740337037459E074-26889
chr73703751537037626E074-26722
chr73703932037040481E074-23867
chr73704605037046100E074-18248
chr73704610237046156E074-18192
chr73704646637046661E074-17687
chr73704672637046841E074-17507
chr73704699737047247E074-17101
chr73704725037047371E074-16977
chr73704746537047588E074-16760
chr73704772237047926E074-16422
chr73704851137048607E074-15741
chr73704971437049764E074-14584
chr73704990837049958E074-14390
chr73705007937050129E074-14219
chr73705268037052730E074-11618
chr73705278237052868E074-11480
chr73705304337053112E074-11236
chr73705317237053222E074-11126
chr73705326637053770E074-10578
chr73705378437053834E074-10514
chr73705433037054387E074-9961
chr73705439137054441E074-9907
chr73705447937054573E074-9775
chr73705527037055339E074-9009
chr73705542237055545E074-8803
chr73705558437055638E074-8710
chr73705575437055973E074-8375
chr73705601137056087E074-8261
chr73705613637056646E074-7702
chr73705675037056790E074-7558
chr73706623437066860E0741886
chr73706691537067021E0742567
chr73706702637067126E0742678
chr73707099537072426E0746647
chr73707247937072839E0748131
chr73707304137073091E0748693
chr73707312537073223E0748777
chr73707341937073528E0749071
chr73707361337073663E0749265
chr73707379337073843E0749445
chr73708260037082677E07418252
chr73708273137082781E07418383
chr73708289237082932E07418544
chr73708295437083004E07418606
chr73708343137083491E07419083
chr73708410337084183E07419755
chr73708425537084325E07419907
chr73708433037084413E07419982
chr73708514637085275E07420798
chr73708553537085605E07421187
chr73708572337085773E07421375
chr73708615437086224E07421806
chr73708628237086332E07421934
chr73708633537086553E07421987
chr73708680137087213E07422453
chr73709391637094112E07429568
chr73709425337095092E07429905
chr73709512537095180E07430777
chr73709520637095256E07430858
chr73709531037095370E07430962
chr73709582037095940E07431472
chr73709621237096282E07431864
chr73709715437097204E07432806
chr73710222437102430E07437876
chr73710254937102659E07438201
chr73710272437102776E07438376
chr73711053737110577E07446189
chr73711403237114109E07449684
chr73711414837114209E07449800
chr73701945037019956E081-44392
chr73702000837020099E081-44249
chr73702035537020587E081-43761
chr73702061737020667E081-43681
chr73702116337021213E081-43135
chr73702129337021434E081-42914
chr73702604637027177E081-37171
chr73703865037038741E081-25607
chr73703908637039136E081-25212
chr73703932037040481E081-23867
chr73704605037046100E081-18248
chr73704610237046156E081-18192
chr73704699737047247E081-17101
chr73704725037047371E081-16977
chr73704746537047588E081-16760
chr73704772237047926E081-16422
chr73704851137048607E081-15741
chr73704883737048937E081-15411
chr73704903837049146E081-15202
chr73704971437049764E081-14584
chr73705378437053834E081-10514
chr73707977237080312E08115424
chr73708093637081444E08116588
chr73708153737081591E08117189
chr73708170437081997E08117356
chr73708200237082159E08117654
chr73708260037082677E08118252
chr73708273137082781E08118383
chr73708289237082932E08118544
chr73708295437083004E08118606
chr73708343137083491E08119083
chr73708410337084183E08119755
chr73708773037087878E08123382
chr73708795637088056E08123608
chr73708806637088138E08123718
chr73708822337088339E08123875
chr73708836837088418E08124020
chr73709222537092740E08127877
chr73709277337092881E08128425
chr73709293137093129E08128583
chr73709313637093217E08128788
chr73709391637094112E08129568
chr73709425337095092E08129905
chr73709512537095180E08130777
chr73709520637095256E08130858
chr73709531037095370E08130962
chr73709582037095940E08131472
chr73709715437097204E08132806
chr73710149437101603E08137146
chr73710161637101789E08137268
chr73710179037101950E08137442
chr73710201137102118E08137663
chr73710222437102430E08137876
chr73710254937102659E08138201
chr73710272437102776E08138376
chr73710864637108805E08144298
chr73710904137109343E08144693
chr73711053737110577E08146189
chr73711288537113119E08148537
chr73711337837113428E08149030
chr73701906037019104E082-45244
chr73701924137019319E082-45029
chr73701933737019387E082-44961
chr73701945037019956E082-44392
chr73702000837020099E082-44249
chr73702035537020587E082-43761
chr73703908637039136E082-25212
chr73703932037040481E082-23867
chr73704536737045792E082-18556
chr73704605037046100E082-18248
chr73704610237046156E082-18192
chr73704646637046661E082-17687
chr73704672637046841E082-17507
chr73704699737047247E082-17101
chr73704725037047371E082-16977
chr73704746537047588E082-16760
chr73704851137048607E082-15741
chr73704883737048937E082-15411
chr73704903837049146E082-15202
chr73705074837050979E082-13369
chr73705304337053112E082-11236
chr73705317237053222E082-11126
chr73705326637053770E082-10578
chr73705378437053834E082-10514
chr73708680137087213E08222453
chr73708722337087434E08222875
chr73708773037087878E08223382
chr73708795637088056E08223608
chr73709425337095092E08229905
chr73710179037101950E08237442
chr73710201137102118E08237663
chr73710222437102430E08237876
chr73710254937102659E08238201










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr73702221737022318E067-42030
chr73702237137022436E067-41912
chr73702247637022633E067-41715
chr73702283637022890E067-41458
chr73702304237023407E067-40941
chr73702350437023544E067-40804
chr73702459637024845E067-39503
chr73702511737026002E067-38346
chr73702221737022318E068-42030
chr73702237137022436E068-41912
chr73702247637022633E068-41715
chr73702283637022890E068-41458
chr73702304237023407E068-40941
chr73702350437023544E068-40804
chr73702459637024845E068-39503
chr73702511737026002E068-38346
chr73702237137022436E069-41912
chr73702247637022633E069-41715
chr73702283637022890E069-41458
chr73702304237023407E069-40941
chr73702350437023544E069-40804
chr73702459637024845E069-39503
chr73702511737026002E069-38346
chr73702221737022318E070-42030
chr73702237137022436E070-41912
chr73702247637022633E070-41715
chr73702283637022890E070-41458
chr73702304237023407E070-40941
chr73702350437023544E070-40804
chr73702459637024845E070-39503
chr73702511737026002E070-38346
chr73702459637024845E071-39503
chr73702511737026002E071-38346
chr73702221737022318E072-42030
chr73702237137022436E072-41912
chr73702247637022633E072-41715
chr73702283637022890E072-41458
chr73702304237023407E072-40941
chr73702350437023544E072-40804
chr73702459637024845E072-39503
chr73702511737026002E072-38346
chr73702237137022436E073-41912
chr73702247637022633E073-41715
chr73702283637022890E073-41458
chr73702304237023407E073-40941
chr73702350437023544E073-40804
chr73702459637024845E073-39503
chr73702511737026002E073-38346
chr73702459637024845E074-39503
chr73702511737026002E074-38346
chr73702304237023407E081-40941
chr73702350437023544E081-40804
chr73702459637024845E081-39503
chr73702511737026002E081-38346
chr73702221737022318E082-42030
chr73702237137022436E082-41912
chr73702247637022633E082-41715
chr73702283637022890E082-41458
chr73702304237023407E082-40941
chr73702350437023544E082-40804
chr73702459637024845E082-39503
chr73702511737026002E082-38346