rs11106345

Homo sapiens
T>C
LOC105369901 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0424 (12651/29832,GnomAD)
T==0476 (13868/29118,TOPMED)
T==0419 (2098/5008,1000G)
T==0375 (1447/3854,ALSPAC)
T==0364 (1348/3708,TWINSUK)
chr12:91932724 (GRCh38.p7) (12q21.33)
AD
GWASdb2
2   publication(s)
See rs on genome
14 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 12NC_000012.12:g.91932724T>C
GRCh37.p13 chr 12NC_000012.11:g.92326500T>C

Gene: LOC105369901, uncharacterized LOC105369901(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105369901 transcript variant X2XR_001749253.1:n.N/AIntron Variant
LOC105369901 transcript variant X3XR_001749254.1:n.N/AIntron Variant
LOC105369901 transcript variant X4XR_001749255.1:n.N/AIntron Variant
LOC105369901 transcript variant X5XR_001749256.1:n.N/AIntron Variant
LOC105369901 transcript variant X1XR_945202.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.641C=0.359
1000GenomesAmericanSub694T=0.440C=0.560
1000GenomesEast AsianSub1008T=0.096C=0.904
1000GenomesEuropeSub1006T=0.387C=0.613
1000GenomesGlobalStudy-wide5008T=0.419C=0.581
1000GenomesSouth AsianSub978T=0.470C=0.530
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.375C=0.625
The Genome Aggregation DatabaseAfricanSub8700T=0.618C=0.382
The Genome Aggregation DatabaseAmericanSub830T=0.420C=0.580
The Genome Aggregation DatabaseEast AsianSub1594T=0.117C=0.883
The Genome Aggregation DatabaseEuropeSub18406T=0.360C=0.639
The Genome Aggregation DatabaseGlobalStudy-wide29832T=0.424C=0.575
The Genome Aggregation DatabaseOtherSub302T=0.350C=0.650
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.476C=0.523
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.364C=0.636
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res
23691058Dosage transmission disequilibrium test (dTDT) for linkage and association detection.Zhang ZPLoS One

P-Value

SNP ID p-value Traits Study
rs111063450.00000722alcohol dependence23691058
rs111063450.00006alcohol dependence20201924
rs111063450.0000602alcoholismpha002892
rs111063450.00037Alcohol dependence (early age of onset)20201924

eQTL of rs11106345 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs11106345 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr129228522792285267E070-41233
chr129228561292285704E070-40796
chr129228576992286134E070-40366
chr129228620492286429E070-40071
chr129228649492286710E070-39790
chr129229048492291024E070-35476
chr129229110292291152E070-35348
chr129227813792278506E081-47994
chr129228576992286134E081-40366
chr129228620492286429E081-40071
chr129228649492286710E081-39790
chr129229110292291152E081-35348
chr129228576992286134E082-40366
chr129228620492286429E082-40071