rs11106374

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0365 (10948/29942,GnomAD)
C=0349 (10167/29118,TOPMED)
C=0377 (1887/5008,1000G)
C=0340 (1312/3854,ALSPAC)
C=0344 (1275/3708,TWINSUK)
chr12:91974317 (GRCh38.p7) (12q21.33)
AD
GWASdb2
1   publication(s)
See rs on genome
64 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 12NC_000012.12:g.91974317T>C
GRCh37.p13 chr 12NC_000012.11:g.92368093T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.643C=0.357
1000GenomesAmericanSub694T=0.560C=0.440
1000GenomesEast AsianSub1008T=0.631C=0.369
1000GenomesEuropeSub1006T=0.643C=0.357
1000GenomesGlobalStudy-wide5008T=0.623C=0.377
1000GenomesSouth AsianSub978T=0.610C=0.390
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.660C=0.340
The Genome Aggregation DatabaseAfricanSub8710T=0.632C=0.368
The Genome Aggregation DatabaseAmericanSub834T=0.530C=0.470
The Genome Aggregation DatabaseEast AsianSub1614T=0.645C=0.355
The Genome Aggregation DatabaseEuropeSub18482T=0.638C=0.361
The Genome Aggregation DatabaseGlobalStudy-wide29942T=0.634C=0.365
The Genome Aggregation DatabaseOtherSub302T=0.700C=0.300
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.650C=0.349
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.656C=0.344
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs111063740.00041alcohol dependence20201924

eQTL of rs11106374 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs11106374 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr129237908692379878E06710993
chr129237992792380182E06711834
chr129238034192380598E06712248
chr129241521492415491E06747121
chr129241549792415820E06747404
chr129237840992378679E06810316
chr129237992792380182E06811834
chr129238034192380598E06812248
chr129238185892382373E06813765
chr129238239492382520E06814301
chr129238254592382624E06814452
chr129238185892382373E06913765
chr129241487392415130E06946780
chr129241521492415491E06947121
chr129241549792415820E06947404
chr129237726192377311E0709168
chr129237735892377408E0709265
chr129237741092377494E0709317
chr129237779292377997E0709699
chr129237822292378408E07010129
chr129237840992378679E07010316
chr129237889292379063E07010799
chr129237908692379878E07010993
chr129237992792380182E07011834
chr129238034192380598E07012248
chr129238073892380790E07012645
chr129238096992381013E07012876
chr129238135792381684E07013264
chr129238185892382373E07013765
chr129238239492382520E07014301
chr129238632392386403E07018230
chr129238650392386662E07018410
chr129238681492386867E07018721
chr129238723692387286E07019143
chr129238746892387522E07019375
chr129238759792387694E07019504
chr129238770392387822E07019610
chr129238793492388056E07019841
chr129238810792388176E07020014
chr129238932392389447E07021230
chr129239728392397343E07029190
chr129239749692397540E07029403
chr129239762792397712E07029534
chr129239772092397824E07029627
chr129237889292379063E07110799
chr129237908692379878E07110993
chr129237992792380182E07111834
chr129238034192380598E07112248
chr129238073892380790E07112645
chr129238096992381013E07112876
chr129238135792381684E07113264
chr129238185892382373E07213765
chr129238239492382520E07214301
chr129238254592382624E07214452
chr129241521492415491E07247121
chr129241549792415820E07247404
chr129237908692379878E07410993
chr129237992792380182E07411834
chr129238185892382373E07413765
chr129238239492382520E07414301
chr129238770392387822E08119610
chr129238793492388056E08119841
chr129238810792388176E08120014
chr129238135792381684E08213264