rs11125811

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0147 (4421/29910,GnomAD)
C=0137 (3993/29116,TOPMED)
C=0150 (752/5008,1000G)
C=0174 (669/3854,ALSPAC)
C=0166 (616/3708,TWINSUK)
chr2:59760639 (GRCh38.p7) (2p16.1)
AD
GWASdb2
1   publication(s)
See rs on genome
54 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.59760639T>C
GRCh37.p13 chr 2NC_000002.11:g.59987774T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.850C=0.150
1000GenomesAmericanSub694T=0.820C=0.180
1000GenomesEast AsianSub1008T=0.871C=0.129
1000GenomesEuropeSub1006T=0.835C=0.165
1000GenomesGlobalStudy-wide5008T=0.850C=0.150
1000GenomesSouth AsianSub978T=0.870C=0.130
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.826C=0.174
The Genome Aggregation DatabaseAfricanSub8696T=0.853C=0.147
The Genome Aggregation DatabaseAmericanSub832T=0.820C=0.180
The Genome Aggregation DatabaseEast AsianSub1620T=0.890C=0.110
The Genome Aggregation DatabaseEuropeSub18460T=0.848C=0.151
The Genome Aggregation DatabaseGlobalStudy-wide29910T=0.852C=0.147
The Genome Aggregation DatabaseOtherSub302T=0.940C=0.060
Trans-Omics for Precision MedicineGlobalStudy-wide29116T=0.862C=0.137
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.834C=0.166
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs111258110.000702alcohol dependence24277619

eQTL of rs11125811 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs11125811 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr25999767759997767E0679903
chr25999782359998206E06710049
chr25999767759997767E0689903
chr25999782359998206E06910049
chr25995264859952711E070-35063
chr25995348359954157E070-33617
chr26001682560017235E07029051
chr26001781460017929E07030040
chr26001801560018333E07030241
chr26001855660018666E07030782
chr26003193860032193E07044164
chr25995465659954876E071-32898
chr25996044459960513E071-27261
chr25996052159960624E071-27150
chr25996064959960721E071-27053
chr25996076959961192E071-26582
chr25999767759997767E0719903
chr25999782359998206E07110049
chr26002589960026096E07138125
chr25999767759997767E0729903
chr25999782359998206E07210049
chr25995264859952711E081-35063
chr25995348359954157E081-33617
chr25995425559954584E081-33190
chr25995465659954876E081-32898
chr25996010859960262E081-27512
chr25996044459960513E081-27261
chr25996052159960624E081-27150
chr25996064959960721E081-27053
chr25996076959961192E081-26582
chr25996201059962145E081-25629
chr25996232859962544E081-25230
chr25997299559973340E081-14434
chr25997338659973662E081-14112
chr25997666359976858E081-10916
chr25997799259978131E081-9643
chr25997939459979523E081-8251
chr25998025459980322E081-7452
chr25998106259981132E081-6642
chr25998129259981415E081-6359
chr25998159959981714E081-6060
chr25998211759982167E081-5607
chr25998494159985030E081-2744
chr25998532059985374E081-2400
chr26000209160002387E08114317
chr26000243960002506E08114665
chr25996642759966560E082-21214
chr25996679959966998E082-20776
chr25997230959972488E082-15286
chr25997299559973340E082-14434
chr25998129259981415E082-6359
chr25998159959981714E082-6060
chr25998532059985374E082-2400
chr26000209160002387E08214317