rs11132226

Homo sapiens
G>A
ENPP6 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0222 (6653/29916,GnomAD)
A=0248 (7223/29118,TOPMED)
A=0263 (1317/5008,1000G)
A=0126 (486/3854,ALSPAC)
A=0141 (521/3708,TWINSUK)
chr4:184144142 (GRCh38.p7) (4q35.1)
ND
GWASdb2
1   publication(s)
See rs on genome
70 Enhancers around
8 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.184144142G>A
GRCh37.p13 chr 4NC_000004.11:g.185065295G>A

Gene: ENPP6, ectonucleotide pyrophosphatase/phosphodiesterase 6(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ENPP6 transcriptNM_153343.3:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.569A=0.431
1000GenomesAmericanSub694G=0.800A=0.200
1000GenomesEast AsianSub1008G=0.771A=0.229
1000GenomesEuropeSub1006G=0.850A=0.150
1000GenomesGlobalStudy-wide5008G=0.737A=0.263
1000GenomesSouth AsianSub978G=0.770A=0.230
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.874A=0.126
The Genome Aggregation DatabaseAfricanSub8702G=0.616A=0.384
The Genome Aggregation DatabaseAmericanSub838G=0.800A=0.200
The Genome Aggregation DatabaseEast AsianSub1620G=0.772A=0.228
The Genome Aggregation DatabaseEuropeSub18454G=0.851A=0.148
The Genome Aggregation DatabaseGlobalStudy-wide29916G=0.777A=0.222
The Genome Aggregation DatabaseOtherSub302G=0.870A=0.130
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.751A=0.248
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.859A=0.141
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet

P-Value

SNP ID p-value Traits Study
rs111322260.00000308Comorbid alcohol and nicotine dependence20158304
rs111322260.0000116Alcohol dependence20158304

eQTL of rs11132226 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs11132226 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr4185021398185021804E067-43491
chr4185036259185036317E067-28978
chr4185036479185036541E067-28754
chr4185036551185036864E067-28431
chr4185075087185075154E0679792
chr4185076687185076735E06711392
chr4185076799185076897E06711504
chr4185077325185077721E06712030
chr4185110538185110876E06845243
chr4185110895185110955E06845600
chr4185111819185112101E06846524
chr4185020276185020434E069-44861
chr4185020468185021092E069-44203
chr4185021398185021804E069-43491
chr4185076687185076735E06911392
chr4185076799185076897E06911504
chr4185077325185077721E06912030
chr4185111819185112101E06946524
chr4185021398185021804E071-43491
chr4185021970185022037E071-43258
chr4185076687185076735E07111392
chr4185076799185076897E07111504
chr4185088708185089365E07123413
chr4185110538185110876E07145243
chr4185110895185110955E07145600
chr4185111138185111481E07145843
chr4185111819185112101E07146524
chr4185021398185021804E072-43491
chr4185021970185022037E072-43258
chr4185076687185076735E07211392
chr4185076799185076897E07211504
chr4185077325185077721E07212030
chr4185111819185112101E07246524
chr4185021398185021804E073-43491
chr4185021970185022037E073-43258
chr4185076687185076735E07311392
chr4185076799185076897E07311504
chr4185077325185077721E07312030
chr4185110895185110955E07345600
chr4185111138185111481E07345843
chr4185111819185112101E07346524
chr4185021398185021804E074-43491
chr4185077325185077721E07412030
chr4185090232185090448E07424937
chr4185110053185110113E07444758
chr4185110538185110876E07445243
chr4185110895185110955E07445600
chr4185111138185111481E07445843
chr4185111819185112101E07446524
chr4185019764185019808E081-45487
chr4185020112185020164E081-45131
chr4185020276185020434E081-44861
chr4185020468185021092E081-44203
chr4185021398185021804E081-43491
chr4185021970185022037E081-43258
chr4185035333185035409E081-29886
chr4185035711185035847E081-29448
chr4185036259185036317E081-28978
chr4185036479185036541E081-28754
chr4185036551185036864E081-28431
chr4185074720185074812E0819425
chr4185075087185075154E0819792
chr4185075197185075327E0819902
chr4185020468185021092E082-44203
chr4185021398185021804E082-43491
chr4185036259185036317E082-28978
chr4185036479185036541E082-28754
chr4185036551185036864E082-28431
chr4185075087185075154E0829792
chr4185075197185075327E0829902









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr4185017690185018773E068-46522
chr4185018778185018888E068-46407
chr4185114636185114712E06849341
chr4185018778185018888E069-46407
chr4185017690185018773E071-46522
chr4185018778185018888E071-46407
chr4185017690185018773E072-46522
chr4185018778185018888E072-46407