rs111645190

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0041 (1234/29548,GnomAD)
A=0044 (221/5008,1000G)

Position: chr19:40855903 (GRCh38.p7) (19q13.2)

Phenotype: ND

Dataset:

GWASCatalog

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 140 Enhancers around

Promoter: 23 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 19	NC_000019.10:g.40855903G>A
GRCh37.p13 chr 19	NC_000019.9:g.41361808G>A

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.840	A=0.160
1000Genomes	American	Sub	694	G=0.990	A=0.010
1000Genomes	East Asian	Sub	1008	G=1.000	A=0.000
1000Genomes	Europe	Sub	1006	G=1.000	A=0.000
1000Genomes	Global	Study-wide	5008	G=0.956	A=0.044
1000Genomes	South Asian	Sub	978	G=1.000	A=0.000
The Genome Aggregation Database	African	Sub	8576	G=0.857	A=0.143
The Genome Aggregation Database	American	Sub	834	G=1.000	A=0.000
The Genome Aggregation Database	East Asian	Sub	1566	G=1.000	A=0.000
The Genome Aggregation Database	Europe	Sub	18270	G=0.999	A=0.000
The Genome Aggregation Database	Global	Study-wide	29548	G=0.958	A=0.041
The Genome Aggregation Database	Other	Sub	302	G=1.000	A=0.000

PMID	Title	Author	Journal
28921760	Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences.	Chenoweth MJ	Addiction

P-Value

SNP ID	p-value	Traits	Study
rs111645190	1E-23	nicotine metabolite ratio in current smokers	28921760

eQTL of rs111645190 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs111645190 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr19	41311901	41311984	E067	-49824
chr19	41314057	41314164	E067	-47644
chr19	41314165	41314366	E067	-47442
chr19	41314383	41314438	E067	-47370
chr19	41314543	41314844	E067	-46964
chr19	41318614	41318775	E067	-43033
chr19	41318893	41318990	E067	-42818
chr19	41319058	41319424	E067	-42384
chr19	41319757	41319828	E067	-41980
chr19	41324139	41324179	E067	-37629
chr19	41324351	41324854	E067	-36954
chr19	41324907	41325135	E067	-36673
chr19	41325420	41326011	E067	-35797
chr19	41328596	41329263	E067	-32545
chr19	41333021	41333471	E067	-28337
chr19	41311901	41311984	E068	-49824
chr19	41313359	41314035	E068	-47773
chr19	41315417	41315497	E068	-46311
chr19	41315541	41315630	E068	-46178
chr19	41315675	41315793	E068	-46015
chr19	41318461	41318553	E068	-43255
chr19	41318614	41318775	E068	-43033
chr19	41318893	41318990	E068	-42818
chr19	41324907	41325135	E068	-36673
chr19	41325420	41326011	E068	-35797
chr19	41328596	41329263	E068	-32545
chr19	41333021	41333471	E068	-28337
chr19	41311901	41311984	E069	-49824
chr19	41313359	41314035	E069	-47773
chr19	41315171	41315349	E069	-46459
chr19	41315417	41315497	E069	-46311
chr19	41315541	41315630	E069	-46178
chr19	41315675	41315793	E069	-46015
chr19	41319058	41319424	E069	-42384
chr19	41319502	41319594	E069	-42214
chr19	41319632	41319711	E069	-42097
chr19	41323661	41323817	E069	-37991
chr19	41323901	41323956	E069	-37852
chr19	41324139	41324179	E069	-37629
chr19	41324351	41324854	E069	-36954
chr19	41324907	41325135	E069	-36673
chr19	41325420	41326011	E069	-35797
chr19	41328368	41328433	E069	-33375
chr19	41328596	41329263	E069	-32545
chr19	41311901	41311984	E070	-49824
chr19	41313359	41314035	E070	-47773
chr19	41314057	41314164	E070	-47644
chr19	41339246	41339303	E070	-22505
chr19	41311901	41311984	E071	-49824
chr19	41313359	41314035	E071	-47773
chr19	41314057	41314164	E071	-47644
chr19	41314165	41314366	E071	-47442
chr19	41314383	41314438	E071	-47370
chr19	41314543	41314844	E071	-46964
chr19	41314849	41314965	E071	-46843
chr19	41315171	41315349	E071	-46459
chr19	41315417	41315497	E071	-46311
chr19	41315541	41315630	E071	-46178
chr19	41315675	41315793	E071	-46015
chr19	41318461	41318553	E071	-43255
chr19	41318614	41318775	E071	-43033
chr19	41318893	41318990	E071	-42818
chr19	41319058	41319424	E071	-42384
chr19	41319502	41319594	E071	-42214
chr19	41319632	41319711	E071	-42097
chr19	41319757	41319828	E071	-41980
chr19	41319892	41320080	E071	-41728
chr19	41324139	41324179	E071	-37629
chr19	41324351	41324854	E071	-36954
chr19	41324907	41325135	E071	-36673
chr19	41325420	41326011	E071	-35797
chr19	41328368	41328433	E071	-33375
chr19	41328596	41329263	E071	-32545
chr19	41329354	41329411	E071	-32397
chr19	41311901	41311984	E072	-49824
chr19	41313359	41314035	E072	-47773
chr19	41314057	41314164	E072	-47644
chr19	41314165	41314366	E072	-47442
chr19	41314383	41314438	E072	-47370
chr19	41314543	41314844	E072	-46964
chr19	41315541	41315630	E072	-46178
chr19	41315675	41315793	E072	-46015
chr19	41318461	41318553	E072	-43255
chr19	41324139	41324179	E072	-37629
chr19	41324907	41325135	E072	-36673
chr19	41328596	41329263	E072	-32545
chr19	41333021	41333471	E072	-28337
chr19	41339828	41339912	E072	-21896
chr19	41404498	41404675	E072	42690
chr19	41311901	41311984	E073	-49824
chr19	41313359	41314035	E073	-47773
chr19	41318461	41318553	E073	-43255
chr19	41318614	41318775	E073	-43033
chr19	41318893	41318990	E073	-42818
chr19	41319058	41319424	E073	-42384
chr19	41324351	41324854	E073	-36954
chr19	41324907	41325135	E073	-36673
chr19	41328009	41328074	E073	-33734
chr19	41328217	41328302	E073	-33506
chr19	41328368	41328433	E073	-33375
chr19	41328596	41329263	E073	-32545
chr19	41333021	41333471	E073	-28337
chr19	41311901	41311984	E074	-49824
chr19	41313359	41314035	E074	-47773
chr19	41314057	41314164	E074	-47644
chr19	41314165	41314366	E074	-47442
chr19	41314383	41314438	E074	-47370
chr19	41315541	41315630	E074	-46178
chr19	41315675	41315793	E074	-46015
chr19	41318461	41318553	E074	-43255
chr19	41318614	41318775	E074	-43033
chr19	41318893	41318990	E074	-42818
chr19	41319058	41319424	E074	-42384
chr19	41319502	41319594	E074	-42214
chr19	41319632	41319711	E074	-42097
chr19	41319757	41319828	E074	-41980
chr19	41319892	41320080	E074	-41728
chr19	41324139	41324179	E074	-37629
chr19	41324351	41324854	E074	-36954
chr19	41325420	41326011	E074	-35797
chr19	41328217	41328302	E074	-33506
chr19	41328368	41328433	E074	-33375
chr19	41328596	41329263	E074	-32545
chr19	41329354	41329411	E074	-32397
chr19	41333021	41333471	E074	-28337
chr19	41339246	41339303	E074	-22505
chr19	41339346	41339498	E074	-22310
chr19	41339828	41339912	E074	-21896
chr19	41354980	41355083	E074	-6725
chr19	41311901	41311984	E081	-49824
chr19	41312044	41313329	E081	-48479
chr19	41324351	41324854	E081	-36954
chr19	41311901	41311984	E082	-49824
chr19	41318461	41318553	E082	-43255
chr19	41318614	41318775	E082	-43033
chr19	41318893	41318990	E082	-42818
chr19	41323661	41323817	E082	-37991
chr19	41323901	41323956	E082	-37852
chr19	41324139	41324179	E082	-37629
chr19	41324351	41324854	E082	-36954

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr19	41316570	41316987	E067	-44821
chr19	41317036	41317275	E067	-44533
chr19	41354337	41354458	E067	-7350
chr19	41354484	41354854	E067	-6954
chr19	41316570	41316987	E068	-44821
chr19	41317036	41317275	E068	-44533
chr19	41316570	41316987	E069	-44821
chr19	41317036	41317275	E069	-44533
chr19	41316570	41316987	E070	-44821
chr19	41317036	41317275	E070	-44533
chr19	41354484	41354854	E070	-6954
chr19	41316570	41316987	E071	-44821
chr19	41317036	41317275	E071	-44533
chr19	41316570	41316987	E072	-44821
chr19	41317036	41317275	E072	-44533
chr19	41354337	41354458	E072	-7350
chr19	41354484	41354854	E072	-6954
chr19	41316570	41316987	E073	-44821
chr19	41317036	41317275	E073	-44533
chr19	41316570	41316987	E074	-44821
chr19	41317036	41317275	E074	-44533
chr19	41316570	41316987	E082	-44821
chr19	41317036	41317275	E082	-44533